RegulonDB RegulonDB 10.7: Operon Form
   

emrKY operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: emrKY
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: emrKY
Gene(s): emrY, emrK   Genome Browser M3D Gene expression COLOMBOS
Note(s): emrK expression is increased at least 5-fold by indole |CITS: [15686558]|.
Based on microarray and RT-qPCR analyses, it was determined that the emrK gene is upregulated upon exposure to glutathione (GSH) |CITS:[29468195]|.
Evidence: [ITC] Inferred through co-regulation
Reference(s): [1] Salmon K., et al., 2003
Promoter
Name: emrKp
+1: 2483448
Distance from start of the gene: 109
Sequence: attgcaaaagccacggtttagtcctctgttgttttttttgcacctcatttaaattaggccTccaacgttcctgggataatg
Evidence: [TIM]
Reference(s): [2] Eguchi Y., et al., 2003
[3] Kato A., et al., 2000
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal EvgA-Phosphorylated activator emrKp 2483513 2483530 -73.5 cttcttactaATCCTACAGGCGTAAGAAttgtattgca nd [AIBSCS], [APIORCISFBSCS], [BPP], [GEA] [2], [3], [4], [5]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
nd FNR1 activator emrKp nd nd nd nd nd [AIBSCS], [GEA] [1]
Note(s): 1By making use of microarray analyses it was concluded that anarobiosis does not affect the expression of the purMN operon, although FNR appears to activate it. A putative FNR-binding site, which is not shown in the paper, was identified upstream of this operon Salmon K,2003.2By making use of microarray analyses it was concluded that anarobiosis does not affect the expression of the purMN operon, although FNR appears to activate it. A putative FNR-binding site, which is not shown in the paper, was identified upstream of this operon Salmon K,2003.


Regulation by sRNA    
  Small RNA name (Regulator) Regulation type Mechanism Function Binding Sites Evidence Reference
LeftPos RightPos Sequence (RNA-strand)
  gcvB unknown unknown repressor       [IMP] [6]
Notes: "The provided sequence is that of the RNA strand,i.e. 'U's are showed instead the 'T'"





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