![]() ![]() ![]() ![]() |
Name: | spy |
Gene(s): | spy Genome Browser M3D Gene expression COLOMBOS |
Note(s): | spy gene expression is induced separately by both copper and zinc metals through the CpxAR and BaeSR sensor response regulatory systems, respectively. BaeR can be the primary regulator and CpxR can enhance its function Yamamoto K,2008. 24999585 On the other hand, BaeR is the primary regulator of spy in the presence of the protein-unfolding agent ethanol 24999585 The expression of the gene spy is increased when colicin (at 30 ng/ml) is added to the medium 23421615. spy is also induced by indole Hirakawa H,2005. Raffa RG,2002. Under conditions leading to NlpE outer membrane lipoprotein overexpression, the transcription of the spy gene is increased by CpxR Raivio TL,2013 |
Evidence: | [BTEI] Boundaries of transcription experimentally identified [LTED] Length of transcript experimentally determined |
Reference(s): |
[1] Hagenmaier S., et al., 1997 [2] Nishino K., et al., 2005 |
Promoter | |
Name: | spyp |
+1: | 1825688 |
Sigma Factor: | Sigma70 Sigmulon |
Distance from start of the gene: | 63 |
Sequence: |
acactttcattgttttaccgttgctctgattaattgacgctaaagtcagtaaagttaatcTcgtcaacacggcacgctact -35 -10 +1 |
Evidence: |
[HIPP] [TIM] |
Reference(s): |
[1] Hagenmaier S., et al., 1997 [3] Yamamoto K., et al., 2006 |
Terminator(s) | |
Type: | rho-independent |
Sequence: | ttgagaagagAAAAGAAAACCGCCGATCCTGTCCACCGCATTACTGCAAGGTAGTGGACAAGACCGGCGGTCTTAAGTTTtttggctgaa |
Reference(s): | [1] Hagenmaier S., et al., 1997 |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | BaeR-Phosphorylated | activator | spyp | 1825765 | 1825784 | -86.5 | atcaaattttCTTTTTTTCTCCATAATTGGcgcaaaagtg | nd | [AIBSCS], [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [2], [4], [5] |
remote | BaeR-Phosphorylated | activator | spyp | 1825836 | 1825855 | -157.5 | ccagtcatccGGTATAGTTCTTCATAATCTctgcaaaatc | nd | [APIORCISFBSCS], [BPP], [IC] | [4] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | CpxR-Phosphorylated1 | activator | spyp | 1825731 | 1825745 | -50.0 | gttttttacaCTTTCATTGTTTTACcgttgctctg | nd | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [3], [5], [6], [7] |
Note(s): | 1The consensus of this CpxR-binding site is not located in the same DNA strand as in the spyp promoter Yamamoto K,20063The consensus of this CpxR-binding site is not located in the same DNA strand as in the spyp promoter Yamamoto K,2006 |
Reference(s) |
![]() |
---|---|