RegulonDB RegulonDB 10.6.3: Operon Form
   

qseBC operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: qseBC
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: qseBC
Gene(s): qseB, qseC   Genome Browser M3D Gene expression COLOMBOS
Evidence: [ITCR] Inferred through co-regulation
Reference(s): [1] Clarke MB., et al., 2005
[2] Sperandio V., et al., 2002
Promoter
Name: qseBp2
+1: 3169749
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 79
Sequence: ctttaatgtctgtttccgagcatttaacaagatagtccttaacaacttcttaagggaaaaAaataaaatttagtgctgtac
                             -35                 -10        +1                   
Evidence: [TIM]
Reference(s): [1] Clarke MB., et al., 2005
TF binding sites (TFBSs)
[BasR,+] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal BasR-Phosphorylated1 activator qseBp2 3169726 3169745 -13.5 caagatagtcCTTAACAACTTCTTAAGGGAaaaaaataaa nd [BPP], [GEA] [4]
[QseB,+] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
remote QseB-Phosphorylated activator qseBp2 3169281 3169293 -462.0 ggagcggtaaCAATTACGGATTTactttgcgga nd [BPP], [GEA] [1], [3]
proximal QseB-Phosphorylated activator qseBp2 3169748 3169760 6.0 ttaagggaaaAAAATAAAATTTAgtgctgtaca nd [BPP], [GEA] [1], [3]
Note(s): 1BasR contributes to qseBC transcription in the absence of QseC in uropathogenic Escherichia coli (UPEC) Guckes KR,2013 Cross-regulation between the QseBC and BasSR two-component systems (TCSs) has been suggested Guckes KR,20132BasR contributes to qseBC transcription in the absence of QseC in uropathogenic Escherichia coli (UPEC) Guckes KR,2013 Cross-regulation between the QseBC and BasSR two-component systems (TCSs) has been suggested Guckes KR,2013


Transcription unit       
Name: qseBC
Gene(s): qseB, qseC   Genome Browser M3D Gene expression COLOMBOS
Evidence: [ITCR] Inferred through co-regulation
Reference(s): [1] Clarke MB., et al., 2005
[2] Sperandio V., et al., 2002
Promoter
Name: qseBp1
+1: 3169801
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 27
Sequence: agggaaaaaaataaaatttagtgctgtacagagcgcgttacaacacggtttactggcagcAaatacggttatcgcagggat
                        -35                        -10      +1                   
Evidence: [TIM]
Reference(s): [1] Clarke MB., et al., 2005


Evidence    

 [TIM] Transcription initiation mapping

 [BPP] Binding of purified proteins

 [GEA] Gene expression analysis


Reference(s)    

 [1] Clarke MB., Sperandio V., 2005, Transcriptional autoregulation by quorum sensing Escherichia coli regulators B and C (QseBC) in enterohaemorrhagic E. coli (EHEC)., Mol Microbiol 58(2):441-55

 [2] Sperandio V., Torres AG., Kaper JB., 2002, Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli., Mol Microbiol 43(3):809-21

 [3] Clarke MB., Sperandio V., 2005, Transcriptional regulation of flhDC by QseBC and sigma (FliA) in enterohaemorrhagic Escherichia coli., Mol Microbiol 57(6):1734-49

 [4] Guckes KR., Kostakioti M., Breland EJ., Gu AP., Shaffer CL., Martinez CR., Hultgren SJ., Hadjifrangiskou M., 2013, Strong cross-system interactions drive the activation of the QseB response regulator in the absence of its cognate sensor., Proc Natl Acad Sci U S A 110(41):16592-7

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