RegulonDB RegulonDB 10.10: Operon Form

flhBAE operon and associated TUs in Escherichia coli K-12 genome

Name: flhBAE
This page displays every known transcription unit of this operon and their known regulation.

Transcription unit          
Name: flhBAE
Gene(s): flhE, flhA, flhB   Genome Browser M3D Gene expression COLOMBOS
Note(s): There is a consensus sequence for a σ28 factor at 120 bp upstream of the transcription initiation site of the flhBp promoter, which could be a second promoter for the flhB operon Liu X,1994 The DNA sequence was not shown.
In a study where it was shown that the L-tryptophan eradicated persister cells, it was observed that the exogenous amino acid downregulated the expression of flhB as well as other flagellar genes Li Y, Liu B, Guo J, Cong H, He S, Zhou H, Zhu F, Wang Q, Zhang L,2019.
Evidence: [ITCR] Inferred through co-regulation
Name: flhBp
+1: 1966216
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 25
Sequence: cgcctgttttgccccttactcaaaccattgaacgctttgcgctctggcatcattcacgctTaatactctttccaggattgg
Evidence: [HIPP]
Reference(s): [1] Liu X., et al., 1994
[2] Liu X., et al., 1996
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal FlhDC activator flhBp 1966247 1966263 -39.0 ctgttttgccCCTTACTCAAACCATTGaacgctttgc nd [GEA], [APIORCISFBSCS], [BPP] [1], [3]
proximal FlhDC activator flhBp 1966275 1966293 -67.5 atgtgtggcaGCAAAAGCCCTAAATCCCGcctgttttgc nd [GEA], [APIORCISFBSCS], [BPP] [1], [3]