RegulonDB RegulonDB 10.8: Operon Form
   

argA operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: argA
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: argA
Gene(s): argA   Genome Browser M3D Gene expression COLOMBOS
Evidence: [AISDTU] Automated inference that a single-gene directon is a transcription unit
Promoter
Name: argAp
+1: 2949156
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 86
Sequence: gtcatctaataaacggtaaacattctttttatattcacggcattactgataaaaaagtcgCtctcgcataaaatttacact
                            -35                   -10       +1                   
Evidence: [AIPP]
Reference(s): [1] Huerta AM., et al., 2003
TF binding sites (TFBSs)
[ArgR,-] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
remote ArgR-L-arginine repressor argAp 2949193 2949211 46.5 ctgcgaaaaaACAGAATAAAAATACACTAatttcgaata nd [AIBSCS], [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] [2], [3], [4]
remote ArgR-L-arginine repressor argAp 2949214 2949231 67.5 atacactaatTTCGAATAATCATGCAAAgaggtgtgcc nd [AIBSCS], [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] [2], [3], [4]


Evidence    

 [AIPP] Automated inference of promoter position

 [AIBSCS] Automated inference based on similarity to consensus sequences

 [APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.

 [BPP] Binding of purified proteins

 [CV(GEA)] cross validation(GEA)

 [GEA] Gene expression analysis


Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [2] Caldara M., Charlier D., Cunin R., 2006, The arginine regulon of Escherichia coli: whole-system transcriptome analysis discovers new genes and provides an integrated view of arginine regulation., Microbiology 152(Pt 11):3343-54

 [3] Charlier D., Roovers M., Van Vliet F., Boyen A., Cunin R., Nakamura Y., Glansdorff N., Pierard A., 1992, Arginine regulon of Escherichia coli K-12. A study of repressor-operator interactions and of in vitro binding affinities versus in vivo repression., J Mol Biol 226(2):367-86

 [4] Makarova KS., Mironov AA., Gelfand MS., 2001, Conservation of the binding site for the arginine repressor in all bacterial lineages., Genome Biol 2(4):RESEARCH0013

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