RegulonDB RegulonDB 10.6.3: Operon Form
   

lldPRD operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: lldPRD
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: lldPRD
Gene(s): lldP, lldR, lldD   Genome Browser M3D Gene expression COLOMBOS
Note(s): The lldPRD operon is induced by l-lactate metabolism |CITS: [18263722]|.
Previously, Lynch and Lin (1996) identified two promoters (lldPp1 and lldPp2) which controlled transcription of the lldPRD operon. They also identified, by computational methods, PdhR as the regulator of the lldPp1 |CITS: [8892825]|. Recently, based on experimental evidence, Aguilera et al. (2008) demonstrated that lldPRD is not under the control of PdhR and that transcription of the lldPRD operon is directed by the single promoter |CITS: [18263722]|.
Evidence: [ITCR] Inferred through co-regulation
Reference(s): [1] Aguilera L., et al., 2008
[2] Dong JM., et al., 1993
Promoter
Name: lldPp
+1: 3777289
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 110
Sequence: tttcccaattaaaactcacatcaatgttgccaatacataacatttagttaaccattcattGtcattatccctacacaacac
                           -35                   -10        +1                   
Note(s): lldPp was identified by Lynch and Lin (1996) Lynch AS,1996. It is 2 bp upstream of the one identified by Aguilera et al. (2008) Aguilera L,2008.
Evidence: [TIM]
Reference(s): [1] Aguilera L., et al., 2008
[3] Lynch AS., et al., 1996
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal ArcA-Phosphorylated repressor lldPp 3777264 3777278 -18.0 gttgccaataCATAACATTTAGTTAaccattcatt nd [AIBSCS], [BPP], [GEA], [HIBSCS] [3], [4], [5]
proximal ArcA-Phosphorylated repressor lldPp 3777291 3777305 10.0 cattcattgtCATTATCCCTACACAacacaattgg nd [BPP], [GEA] [3], [4], [5]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
remote LldR dual lldPp 3777181 3777203 -97.0 ctccccccacAAGAATTGGCCCTACCAATTCTTcgcttatctg nd [AIBSCS], [BPP], [GEA], [SM] [1]
remote LldR-(S)-lactate dual lldPp 3777181 3777203 -97.0 ctccccccacAAGAATTGGCCCTACCAATTCTTcgcttatctg nd [AIBSCS], [BPP], [GEA], [SM] [1]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal LldR repressor lldPp 3777307 3777329 30.0 ccctacacaaCACAATTGGCAGTGCCACTTTTAcacaacgtgt nd [AIBSCS], [BPP], [GEA], [HIBSCS], [SM] [1], [3]





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