|Gene(s):||rybB Genome Browser M3D Gene expression COLOMBOS|
|Note(s):||The expression of the rybB gene is enhanced during the transition from the exponential to the stationary phase Johansen J,2006 but this induction is RpoS independent Thompson KM,2007
The NsrR transcriptional repressor regulates negatively the transcription of the rybB gene, but it is not known if this effect is direct or indirect Thompson KM,2007
The RNA produced by the rybB gene has been observed mainly in the poles of the cell during stress conditions 31540875.
|Evidence:||[BTEI] Boundaries of transcription experimentally identified
[ICWHO] Inferred computationally without human oversight
[LTED] Length of transcript experimentally determined
|Reference(s):|| Vogel J., et al., 2003|
|Sigma Factor:||Sigma24 Sigmulon|
|Distance from start of the gene:||0|
-35 -10 +1
|Note(s):||A mutation in the rpoE gene was done and it was observed that this mutation causes inactivation of the rybBp promoter Johansen J,2006
This promoter appears to be induced in two phases after σE induction. It is induced during the first 5 minutes following σE induction, decreased from 5 to 10 minutes, induced from 10 to 15 minutes, and decreased from 15 to 20 minutes Lacoux C,2020.
 Johansen J., et al., 2006
 Salgado H, et al., 2012
 Thompson KM., et al., 2007
 Vogel J., et al., 2003
[BPP] Binding of purified proteins
[IEP] Inferred from expression pattern
|Reference(s):|| Costanzo A., et al., 2008|
 Vogel J., Bartels V., Tang TH., Churakov G., Slagter-Jager JG., Huttenhofer A., Wagner EG., 2003, RNomics in Escherichia coli detects new sRNA species and indicates parallel transcriptional output in bacteria., Nucleic Acids Res 31(22):6435-43
 Johansen J., Rasmussen AA., Overgaard M., Valentin-Hansen P., 2006, Conserved small non-coding RNAs that belong to the sigmaE regulon: role in down-regulation of outer membrane proteins., J Mol Biol 364(1):1-8
 Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.
 Costanzo A., Nicoloff H., Barchinger SE., Banta AB., Gourse RL., Ades SE., 2008, ppGpp and DksA likely regulate the activity of the extracytoplasmic stress factor sigmaE in Escherichia coli by both direct and indirect mechanisms., Mol Microbiol 67(3):619-32