RegulonDB RegulonDB 10.8: Operon Form
   

adiC operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: adiC
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: adiC
Gene(s): adiC   Genome Browser M3D Gene expression COLOMBOS
Note(s): The expression of the gene adiC is increased under acidic growth conditions in either aerobiosis or microaerobiosis Marzan LW,2013 The increased expression under aerobiosis appears to be caused by the transcription factor PhoB Marzan LW,2013
Evidence: [ICWHO] Inferred computationally without human oversight
Promoter
Name: adiCp7
+1: 4337202
Sigma Factor: Sigma32 Sigmulon
Distance from start of the gene: 171
Sequence: acagtacgtcgtactttatttctgtctttaaagacttctacggtatgacgccgctgcattAtgttagtcagcacagagaac
                          -35                    -10        +1                   
Note(s): Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: poor homology. Score: 4.059. P-value: 4.362e-5
Evidence: [ICWHO]
Reference(s): [1] Huerta AM., et al., 2003
TF binding sites (TFBSs)
[GadRcs,+] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
nd GadE-RcsB activator adiCp7 nd nd nd nd nd [BPP] [3]
[PhoB,+] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
nd PhoB-Phosphorylated activator adiCp7 nd nd nd nd nd [GEA] [2]


Evidence    

 [ICWHO] Inferred computationally without human oversight

 [BPP] Binding of purified proteins

 [GEA] Gene expression analysis


Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [2] Marzan LW., Hasan CM., Shimizu K., 2013, Effect of acidic condition on the metabolic regulation of Escherichia coli and its phoB mutant., Arch Microbiol 195(3):161-71

 [3] Krin E., Danchin A., Soutourina O., 2010, RcsB plays a central role in H-NS-dependent regulation of motility and acid stress resistance in Escherichia coli., Res Microbiol 161(5):363-371

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