RegulonDB RegulonDB 10.7: Operon Form

rcnR operon and associated TUs in Escherichia coli K-12 genome

Name: rcnR
This page displays every known transcription unit of this operon and their known regulation.

Transcription unit          
Gene(s): rcnR   Genome Browser M3D Gene expression COLOMBOS
Note(s): In response to increasing concentrations of nickel or cobalt, RcnR releases the repression of rcnA and rcnR to allow its expression |CITS:[16956381][19703465]|. It has been recently determined that the expression levels of the rcnA and rcnR genes are directly induced by Ni and Co via the metallo-regulator RcnR, and both genes are differentially expressed |CITS:[21040754]|. In addition, in 2007 Koch et al. showed that the expression of this gene was affected positively by iron; it is uncertain whether this gene is activated by FUR |CITS:[ 17120142]|.
Evidence: [ICWHO] Inferred computationally without human oversight
Name: rcnRp
+1: 2185903
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 107
Sequence: aagaaccaggcgtttccttgctgaagaagagttgtaaattcggtcatgataataattcttAgtattaattcggcaatctga
                        -35                       -10       +1                   
Evidence: [TIM]
Reference(s): [1] Blaha D., et al., 2011
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
remote RcnR repressor rcnRp 2185845 2185859 51.5 cagtacctgaTACTACCCCCCAGTAgattaatagt nd [BPP], [GEA] [1], [2], [3], [4]
remote RcnR repressor rcnRp 2185865 2185879 31.5 aatctgattcTACTCCCCCCCAGTAcctgatacta nd [BPP], [GEA] [1], [2], [3], [4]