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Name: | elaB |
Gene(s): | elaB Genome Browser M3D Gene expression COLOMBOS |
Note(s): | The transcription of elaB is induced in the stationary phase when the cells are growing principally in minimal medium rather than LB medium. elaB expression contributes to cell survival under oxidative and heat shock stress conditions. On the other hand, the deletion of elaB increased the formation of persister cells Guo Y,2017 |
Evidence: | [ICWHO] Inferred computationally without human oversight |
Promoter | |
Name: | elaBp |
+1: | 2381053 |
Sigma Factor: | Sigma38 Sigmulon |
Distance from start of the gene: | 26 |
Sequence: |
ttgggatggcacgcgaggtaattcaggcgtaatcaacaacccttgtctatagttagtgacAggttttacgcaaatggagaa -35 -10 +1 |
Note(s): | Zaslaver et al. demonstrated in 2006, by means of a library of fluorescent transcription fusions, that this promoter can be transcribed in vitro Zaslaver A,2006. Based on this, a putative promoter was suggested, but the +1 site of the transcription initiation has not been determined, although there exists promoter activity. |
Evidence: |
[CV(RS-EPT-CBR)] [CV(TIM)] [ICA] [IEP] [RS-EPT-CBR] [TIM] |
Reference(s): |
[1] Guo Y., et al., 2019 [2] Guo Y., et al., 2017 [3] Salgado H, et al., 2012 [4] Zaslaver A., et al., 2006 |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | OxyR1 | activator | elaBp | 2381061 | 2381107 | -31.0 | cacattgggaTGGCACGCGAGGTAATTCAGGCGTAATCAACAACCCTTGTCTATAGTtagtgacagg | nd | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] | [1] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | OxyR1 | repressor | elaBp | 2381061 | 2381107 | -31.0 | cacattgggaTGGCACGCGAGGTAATTCAGGCGTAATCAACAACCCTTGTCTATAGTtagtgacagg | nd | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] | [1] |
Note(s): |
1 During the exponential phase and under oxidative stress, elaB expression is induced in an OxyR- and RpoS-dependent way, but during stationary phase, elaB does not need OxyR or RpoS to induce its expression; even OxyR represses the expression of elaB under these growth conditions Guo Y,2019. In addition to the TFBS located at -31 from the TSS, there is another TFBS located at -358.5 from the TSS of the promoter of elaB that could bind to OxyR. However, it appears not to be important for elaB regulation by OxyR, because when this site is mutated no changes in expression are observed Guo Y,2019 1 During the exponential phase and under oxidative stress, elaB expression is induced in an OxyR- and RpoS-dependent way, but during stationary phase, elaB does not need OxyR or RpoS to induce its expression; even OxyR represses the expression of elaB under these growth conditions Guo Y,2019. In addition to the TFBS located at -31 from the TSS, there is another TFBS located at -358.5 from the TSS of the promoter of elaB that could bind to OxyR. However, it appears not to be important for elaB regulation by OxyR, because when this site is mutated no changes in expression are observed Guo Y,2019 1 During the exponential phase and under oxidative stress, elaB expression is induced in an OxyR- and RpoS-dependent way, but during stationary phase, elaB does not need OxyR or RpoS to induce its expression; even OxyR represses the expression of elaB under these growth conditions Guo Y,2019. In addition to the TFBS located at -31 from the TSS, there is another TFBS located at -358.5 from the TSS of the promoter of elaB that could bind to OxyR. However, it appears not to be important for elaB regulation by OxyR, because when this site is mutated no changes in expression are observed Guo Y,2019 2 During the exponential phase and under oxidative stress, elaB expression is induced in an OxyR- and RpoS-dependent way, but during stationary phase, elaB does not need OxyR or RpoS to induce its expression; even OxyR represses the expression of elaB under these growth conditions Guo Y,2019. In addition to the TFBS located at -31 from the TSS, there is another TFBS located at -358.5 from the TSS of the promoter of elaB that could bind to OxyR. However, it appears not to be important for elaB regulation by OxyR, because when this site is mutated no changes in expression are observed Guo Y,2019 |
Reference(s) |
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