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Name: | rprA | |||||||||
Gene(s): | rprA Genome Browser M3D Gene expression COLOMBOS | |||||||||
Note(s): | The expression of the gene rprA is increased when colicin (at 30 ng/ml) is added to the medium Kamen?ek S, ?gur-Bertok D,2013. RcsB regulates rprA transcription by both phosphorylation and acetylation. RcsBs phosphorylation and control of rprA transcription requires acetyl-phosphate (AcP) as the group donor. RcsB isolated from ackA or cob mutants is hyperacetylated, and this hyperacetylation inhibits RcsB activity through the acetylation of Lys-154, which plays an important role in rprA regulation Hu LI, Chi BK, Kuhn ML, Filippova EV, Walker-Peddakotla AJ, Bäsell K, Becher D, Anderson WF, Antelmann H, Wolfe AJ,2013 This is the first report that in vivo acetylation by multiple lysines of a bacterial transcription factor regulates its activity Hu LI, Chi BK, Kuhn ML, Filippova EV, Walker-Peddakotla AJ, Bäsell K, Becher D, Anderson WF, Antelmann H, Wolfe AJ,2013 rprA is induced under biofilm conditions Szczesny M, Beloin C, Ghigo JM,2018 |
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Evidence: | [ICWHO] Inferred computationally without human oversight [LTED] Length of transcript experimentally determined |
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Reference(s): | [1] Argaman L., et al., 2001 | |||||||||
Promoter | ||||||||||
Name: | rprAp | |||||||||
+1: | 1770372 | |||||||||
Distance from start of the gene: | 0 | |||||||||
Sequence: |
ttttaaactaatgagacgaatctgatcgacgcaaaaagtccgtatgcctactattagctcAcggttataaatcaacatatt |
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Evidence: | [TIM] | |||||||||
Reference(s): | [1] Argaman L., et al., 2001 |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
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LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | RcsB-phosphorylated | activator | rprAp | 1770323 | 1770336 | -42.5 | tttaaactaaTGAGACGAATCTGAtcgacgcaaa | nd | [GEA], [APIORCISFBSCS], [SM] | [2] |
Reference(s) |
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