RegulonDB RegulonDB 10.10: Operon Form
   

rprA operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: rprA
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: rprA
Gene(s): rprA   Genome Browser M3D Gene expression COLOMBOS
Note(s): The expression of the gene rprA is increased when colicin (at 30 ng/ml) is added to the medium Kamen?ek S, ?gur-Bertok D,2013. RcsB regulates rprA transcription by both phosphorylation and acetylation. RcsBs phosphorylation and control of rprA transcription requires acetyl-phosphate (AcP) as the group donor. RcsB isolated from ackA or cob mutants is hyperacetylated, and this hyperacetylation inhibits RcsB activity through the acetylation of Lys-154, which plays an important role in rprA regulation Hu LI, Chi BK, Kuhn ML, Filippova EV, Walker-Peddakotla AJ, Bäsell K, Becher D, Anderson WF, Antelmann H, Wolfe AJ,2013 This is the first report that in vivo acetylation by multiple lysines of a bacterial transcription factor regulates its activity Hu LI, Chi BK, Kuhn ML, Filippova EV, Walker-Peddakotla AJ, Bäsell K, Becher D, Anderson WF, Antelmann H, Wolfe AJ,2013
rprA is induced under biofilm conditions Szczesny M, Beloin C, Ghigo JM,2018
Evidence: [ICWHO] Inferred computationally without human oversight
[LTED] Length of transcript experimentally determined
Reference(s): [1] Argaman L., et al., 2001
Promoter
Name: rprAp
+1: 1770372
Distance from start of the gene: 0
Sequence: ttttaaactaatgagacgaatctgatcgacgcaaaaagtccgtatgcctactattagctcAcggttataaatcaacatatt
Evidence: [TIM]
Reference(s): [1] Argaman L., et al., 2001
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
nd CpxR-phosphorylated activator rprAp nd nd nd nd nd [GEA], [BPP] [3]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal RcsB-phosphorylated activator rprAp 1770323 1770336 -42.5 tttaaactaaTGAGACGAATCTGAtcgacgcaaa nd [GEA], [APIORCISFBSCS], [SM] [2]





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