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Name: | ftnA |
Gene(s): | ftnA Genome Browser M3D Gene expression COLOMBOS |
Note(s): | Fur antagonizes the H-NS effect in the ftnA promoter. Fur reverses H-NS-mediated repression of ftnA; displacement of H-NS from sites II (-130.5), III (-83), and IV (-56) prevents cooperative binding at sites V (-21) and VI (+16) and leads to derepression Nandal A,2010 H-NS represses the ftnA operon through six AT-rich binding sites that oligomerize and cause DNA looping Nandal A,2010 The displacement of the upstream sites of H-NS by Fur prevents cooperative H-NS binding at the downstream sites on the transcriptional start site of the ftnA promoter, which allows access to RNA polymerase Nandal A,2010 This manner of activation by Fe2+-Fur through H-NS antisilencing represents a new mechanism for iron-induced gene expression. In addition, ftnA is the first example of a gene with a defined alternative Fe2+-Fur induction pathway in Escherichia coli Nandal A,2010 Hepcidin, an antimicrobial peptide, increases the expression of ftnA under conditions of iron availability, in a Fur-independent way 29659799 Expression of ftnA, along with that of other genes also regulated by Fur, is induced under Zn excess Xu Z,2019. |
Evidence: | [ICWHO] Inferred computationally without human oversight [LTED] Length of transcript experimentally determined |
Reference(s): | [1] Izuhara M., et al., 1991 |
Promoter | |
Name: | ftnAp |
+1: | 1988682 |
Sigma Factor: | Sigma70 Sigmulon |
Distance from start of the gene: | 34 |
Sequence: |
ataattgaagtttatattttaccttttgcaaataataaaataacaaattatagtgacgccAcagcaacaaatataaccttt -35 -10 +1 |
Evidence: |
[HIPP] [RS-EPT-CBR] |
Reference(s): |
[1] Izuhara M., et al., 1991 [2] Salgado H, et al., 2012 |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | Fur-Fe2+ | activator | ftnAp | 1988584 | 1988602 | -89.0 | tgattaaagaAATAGCGGTAATGCGTTTTattcccattc | nd | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [3] |
proximal | Fur-Fe2+ | activator | ftnAp | 1988590 | 1988609 | -83.0 | aagaaatagcGGTAATGCGTTTTATTCCCAttcgtatttt | nd | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [3] |
proximal | Fur-Fe2+ | activator | ftnAp | 1988596 | 1988614 | -77.0 | tagcggtaatGCGTTTTATTCCCATTCGTatttttaata | nd | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [3] |
proximal | Fur-Fe2+ | activator | ftnAp | 1988602 | 1988620 | -71.0 | taatgcgtttTATTCCCATTCGTATTTTTaataattgaa | nd | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [3] |
proximal | Fur-Fe2+ | activator | ftnAp | 1988608 | 1988626 | -65.0 | gttttattccCATTCGTATTTTTAATAATtgaagtttat | nd | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [3] |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
remote | H-NS | repressor | ftnAp | 1988546 | 1988556 | -131.5 | ctttctctaaATATTTTAATCagcgagggga | nd | [BPP], [GEA] | [3] |
remote | H-NS | repressor | ftnAp | 1988571 | 1988591 | -101.5 | aggggatcttCGCTGATTAAAGAAATAGCGGtaatgcgttt | nd | [BPP], [GEA] | [3] |
proximal | H-NS | repressor | ftnAp | 1988590 | 1988609 | -83.0 | aagaaatagcGGTAATGCGTTTTATTCCCAttcgtatttt | nd | [BPP], [GEA] | [3] |
proximal | H-NS | repressor | ftnAp | 1988609 | 1988644 | -56.0 | ttttattcccATTCGTATTTTTAATAATTGAAGTTTATATTTTACCttttgcaaat | nd | [BPP], [GEA] | [3] |
proximal | H-NS | repressor | ftnAp | 1988646 | 1988678 | -20.5 | tattttacctTTTGCAAATAATAAAATAACAAATTATAGTGACgccacagcaa | nd | [BPP], [GEA] | [3] |
proximal | H-NS | repressor | ftnAp | 1988687 | 1988707 | 15.5 | acgccacagcAACAAATATAACCTTTGTGGAgcactatcat | nd | [BPP], [GEA] | [3] |
RNA cis-regulatory element | ![]() |
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Regulation, transcriptional elongation | |
Attenuator type: | Translational |
Strand: | forward |
Structure type | Energy | LeftPos | RightPos | Sequence (RNA-strand) | |
---|---|---|---|---|---|
terminator | -11.76 | 1988671 | 1988714 | taacaaattaTAGTGACGCCACAGCAACAAATATAACCTTTGTGGAGCACTATcatgctgaaa |
Notes: "The provided "Sequence" is that of the RNA strand, i.e. U's are shown instead of T's and regulators on the reverse strand will appear as the reverse complement of the sequence delimited by LeftPos-RigtPos" |
Reference(s) |
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