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Name: | hemB |
Gene(s): | hemB Genome Browser M3D Gene expression COLOMBOS |
Note(s): | A potential RNA G-quadruplex structure, formed by guanine-rich sequences located in the coding sequence region of the gene, was identified for hemB . This structure could regulate the expression of the gene, as observed for hemL gene expression 31964733. |
Evidence: | [BTEI] Boundaries of transcription experimentally identified [ICWHO] Inferred computationally without human oversight |
Reference(s): | [1] Echelard Y., et al., 1988 |
Promoter | |
Name: | hemBp |
+1: | 389754 |
Sigma Factor: | Sigma70 Sigmulon |
Distance from start of the gene: | 27 |
Sequence: |
tgtcaacatcgcgacaactttcgtaaaacatccctaccctgcttcaggtatactatgcccCtcgattccacaaacatcagg -35 -10 +1 |
Note(s): | The -10 box of hemB (TATACT) shows a typical Pribnow box, differing only by 1 nucleotide (TATAAT). On the other hand, the -35 sequence, GTAAAA, is atypical, compared with the consensus sequence, TTGACA, for this box Echelard Y,1988. The authors suggested that mutation/deletion studies will allow better definition of its position Echelard Y,1988. |
Evidence: |
[CV(RS-EPT-CBR)] [CV(TIM)] [RS-EPT-CBR] [TIM] |
Reference(s): |
[1] Echelard Y., et al., 1988 [2] Salgado H, et al., 2012 |
Reference(s) |
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