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| Operon |  |
|---|---|
| Name: | hemB |
| This page displays every known transcription unit of this operon and their known regulation. | |
| Name: | hemB |
| Gene(s): | hemB Genome Browser M3D Gene expression COLOMBOS |
| Note(s): | A potential RNA G-quadruplex structure, formed by guanine-rich sequences located in the coding sequence region of the gene, was identified for hemB . This structure could regulate the expression of the gene, as observed for hemL gene expression Shao X, Zhang W, Umar MI, Wong HY, Seng Z, Xie Y, Zhang Y, Yang L, Kwok CK, Deng X,2020. |
| Evidence: | [COMP-AINF] Inferred computationally without human oversight [EXP-IDA-BOUNDARIES-DEFINED] Boundaries of transcription experimentally identified |
| Reference(s): | [1] Echelard Y., et al., 1988 |
| Promoter | |
| Name: | hemBp |
| +1: | 389754 |
| Sigma Factor: | Sigma70 Sigmulon |
| Distance from start of the gene: | 27 |
| Sequence: |
tgtcaacatcgcgacaactttcgtaaaacatccctaccctgcttcaggtatactatgcccCtcgattccacaaacatcagg -35 -10 +1 |
| Note(s): | The -10 box of hemB (TATACT) shows a typical Pribnow box, differing only by 1 nucleotide (TATAAT). On the other hand, the -35 sequence, GTAAAA, is atypical, compared with the consensus sequence, TTGACA, for this box Echelard Y,1988. The authors suggested that mutation/deletion studies will allow better definition of its position Echelard Y,1988. |
| Evidence: |
[COMP-HINF] [EXP-IDA-TRANSCRIPTION-INIT-MAPPING] [RS-EPT-CBR] |
| Reference(s): |
[1] Echelard Y., et al., 1988 [2] Salgado H, et al., 2012 |
| Reference(s) |
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|---|---|
[COMP-HINF] Inferred by a human based on computational evidence