RegulonDB RegulonDB 10.8: Operon Form
   

bhsA operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: bhsA
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit       
Name: bhsA
Gene(s): bhsA   Genome Browser M3D Gene expression COLOMBOS
Evidence: [IC] Inferred by curator
Promoter
Name: bhsAp9
+1: 1169019
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 54
Sequence: attaatgattgttataaaaaatatcttgtatgtgatccagatcacatctatcatttagttAtcgatcgttaagtaattgct
                          -35                    -10        +1                   
Note(s): Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 5.196. P-value: 4.725e-5
The bhsAp9 promoter is significantly affected by ectopic production of a nanoRNase during stationary-phase growth Vvedenskaya IO,2012
Evidence: [ICWHO]
[TIM]
Reference(s): [1] Huerta AM., et al., 2003
[2] Vvedenskaya IO., et al., 2012


Transcription unit          
Name: ycfR
Gene(s): bhsA   Genome Browser M3D Gene expression COLOMBOS
Evidence: [AISDTU] Automated inference that a single-gene directon is a transcription unit
Promoter
Name: bhsAp
+1: 1169033
Sigma Factor: Sigma24 Sigmulon
Distance from start of the gene: 40
Sequence: taaaaaatatcttgtatgtgatccagatcacatctatcatttagttatcgatcgttaagtAattgcttgcgacgtcattca
Evidence: [HTIM]
Reference(s): [3] Raghavan R., et al., 2011
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal CRP-cAMP repressor bhsAp 1168986 1169008 -36.5 aaaatatcttGTATGTGATCCAGATCACATCTAtcatttagtt nd [APIORCISFBSCS], [BPP], [CV(CHIP-SV/GEA/ROMA)], [CV(GEA/ROMA)], [GEA] [3], [4]
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
nd ComR1 repressor bhsAp nd nd nd nd nd [BPP], [GEA] [5]
Note(s): 1The exact position where ComR binds to the bhsA gene is not known. However, it has been suggested that ComR binds to a 60 bp region upstream of the bhsA gene, based on analysis of PCR fragments Mermod M,2012.
Currently, it seems that bhsA is a unique gene of the nearly up- and downstream comR/bhsA region regulated by ComR Mermod M,2012.
Induction by copper is the principal regulation mechanism of the bhsA gene Mermod M,2012.
2The exact position where ComR binds to the bhsA gene is not known. However, it has been suggested that ComR binds to a 60 bp region upstream of the bhsA gene, based on analysis of PCR fragments Mermod M,2012.
Currently, it seems that bhsA is a unique gene of the nearly up- and downstream comR/bhsA region regulated by ComR Mermod M,2012.
Induction by copper is the principal regulation mechanism of the bhsA gene Mermod M,2012.





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