RegulonDB RegulonDB 10.6.3: Operon Form
   

rcsDB operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: rcsDB
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: rcsDB
Gene(s): rcsD, rcsB   Genome Browser M3D Gene expression COLOMBOS
Evidence: [IHBCE] Inferred by a human based on computational evidence
[LTED] Length of transcript experimentally determined
[PAGTSBP] Products of adjacent genes in the same biological process
Reference(s): [1] Krin E., et al., 2010
Promoter
Name: rcsDp
+1: 2313452
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 36
Sequence: tagagaatcatcaatcaggtaagagtctggaatttcacactgtaccctttatactgccctAtcacttcgcgaagttttaac
                           -35                    -10       +1                   
Evidence: [TIM]
Reference(s): [1] Krin E., et al., 2010
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
nd H-NS repressor rcsDp nd nd nd nd nd [BPP] [2]


Transcription unit       
Name: rcsB
Gene(s): rcsB   Genome Browser M3D Gene expression COLOMBOS
Note(s): An integrated transcriptomic study of the extracytoplasmic stress response, which detects and responds to alterations of the bacterial envelope, was performed by Bury-Mor¿¿ et al. (2009). They investigated the interconnections and dynamics between Bae, Cpx, Psp, Rcs, and σE pathways and showed that these pathways can be activated simultaneously in response to exogenous or endogenous stimulation, while natural environmental stimuli provoke bacterial modifications that lead to multiple pathway responses |CITS:[19763168]|.
Each of these responses might be specialized to ensure a specific aspect of envelope biogenesis and maintenance; on the other hand, CpxR could have a role as a modulator of the response by integrating other endogenous signals. Bury-Mor¿¿ et al. concluded that all five pathways are needed to mount a full response to extracytoplasmic stress |CITS:[19763168]|.
Evidence: [LTED] Length of transcript experimentally determined
Reference(s): [3] Jayaratne P., et al., 1993
[1] Krin E., et al., 2010
Promoter
Name: rcsBp1
+1: 2315695
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 482
Sequence: gggtgcaacctgtatcacacccgatgaaagattaattagtcaagattatgatatctttttAacggataatccgtctaatct
                        -35                    -10          +1                   
Evidence: [TIM]
Reference(s): [1] Krin E., et al., 2010


Transcription unit       
Name: rcsB
Gene(s): rcsB   Genome Browser M3D Gene expression COLOMBOS
Evidence: [LTED] Length of transcript experimentally determined
Reference(s): [1] Krin E., et al., 2010
Promoter
Name: rcsBp2
+1: 2315975
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 202
Sequence: tattatgcgctctttgtagacacagtaccggatgatgttaagaggctgtatactgaagcaGcaaccagtgactttgctgcg
                         -35                     -10        +1                   
Evidence: [TIM]
Reference(s): [1] Krin E., et al., 2010





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