RegulonDB RegulonDB 11.1: Operon Form

micA operon and associated TUs in Escherichia coli K-12 genome

Name: micA
This page displays every known transcription unit of this operon and their known regulation.

Transcription unit       
Name: micA
Synonym(s): sraD
Gene(s): micA   Genome Browser M3D Gene expression COLOMBOS
Note(s): The expression of the micA gene is enhanced during the transition from the exponential to the stationary phase Johansen J,2006
The RNA produced by the micA gene has been observed mainly in the poles of the cell during stress conditions Kannaiah S, Livny J, Amster-Choder O,2019.
Evidence: [COMP-AINF-SINGLE-DIRECTON] Automated inference that a single-gene directon is a transcription unit
[EXP-IDA-TRANSCRIPT-LEN-DETERMINATION] Length of transcript experimentally determined
Reference(s): [1] Argaman L., et al., 2001
Name: micAp
+1: 2814802
Sigma Factor: Sigma24 Sigmulon
Distance from start of the gene: 0
Sequence: ctccggtaatttttttaaaaattttctgaactctttcttcccaggcgagtctgagtatatGaaagacgcgcatttgttatc
                            -35                   -10       +1                   
Note(s): A mutation in the rpoE gene was created, and it was observed that this mutation causes inactivation of the micAp promoter Johansen J,2006 This promoter appears to be induced in two phases after σE induction. It is induced during the first 5 minutes following σE induction, decreased from 5 to 10 minutes, induced from 10 to 15 minutes, and decreased from 15 to 20 minutes Lacoux C,2020.
Evidence: [COMP-AINF]
Reference(s): [1] Argaman L., et al., 2001
[2] Huerta AM., et al., 2003
[3] Johansen J., et al., 2006

RNA cis-regulatory element    
Regulation, transcriptional elongation  
Attenuator type: Transcriptional
Strand: forward
  Structure type Energy LeftPos RightPos Sequence (RNA-strand)
  terminator -10.01 2814626 2814667 gcgcagatcgAACACGGTGATTGCGTCGCCATGCGGGGTGTTCATTGTTTTcgccacccga
  anti-terminator -13.1 2814592 2814636 tttctggcatCACTTCTTTGTTCGGCACGCAGAAGCGCAGATCGAACACGGTGAttgcgtcgcc
  anti-anti-terminator -13.0 2814560 2814610 agcaaacaggTGCTCCAGGGTATGGATCCCTCTTTCTGGCATCACTTCTTTGTTCGGCACgcagaagcgc
Notes: "The provided "Sequence" is that of the RNA strand, i.e. U's are shown instead of T's and regulators on the reverse strand will appear as the reverse complement of the sequence delimited by LeftPos-RigtPos"