RegulonDB RegulonDB 11.0: Operon Form
   

hicAB operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: hicAB
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: hicAB
Gene(s): hicA, hicB   Genome Browser M3D Gene expression COLOMBOS
Evidence: [ICWHO] Inferred computationally without human oversight
[PAGTSBP] Products of adjacent genes in the same biological process
Reference(s): [1] Jorgensen MG., et al., 2009
Promoter
Name: hicAp1
+1: 1509221
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 65
Sequence: cttccttcctgattttgcattgcattctgccgttgcggcgatttagtgctattttcgagcAaattacacacggaggtaaac
                           -35                    -10       +1                   
Evidence: [ICWHO]
[IHBCE]
[TIM]
Reference(s): [2] Huerta AM., et al., 2003
[1] Jorgensen MG., et al., 2009
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal CRP-cyclic-AMP activator hicAp1 1509152 1509174 -58.5 cgcaaagaaaTTCTGGAATCTTCCTTCCTGATTttgcattgca nd [GEA], [APIORCISFBSCS] [3]


Transcription unit          
Name: hicAB
Gene(s): hicA, hicB   Genome Browser M3D Gene expression COLOMBOS
Note(s): When hicAB mRNA is produced from hicAp2, only the hicB cistron is translated; that is, this mRNA produces only HicB but not the HicA protein. This happens because this transcript starts just 1 base upstream of the SD sequence of hicA Turnbull KJ,2017.
The hicAB operon is induced in response to amino acid and carbon starvation Jorgensen MG,2009
Evidence: [ICWHO] Inferred computationally without human oversight
[PAGTSBP] Products of adjacent genes in the same biological process
Promoter
Name: hicAp2
+1: 1509275
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 11
Sequence: tcgagcaaattacacacggaggtaaacactaatgtttactttgttgatatactcagcggcAgggaggcgatgtgaaacaaa
                       -35                      -10         +1                   
Note(s): The activation of the promoter hicAp2 is not affected by the Sxy protein, whereas the hicAp1 promoter is Turnbull KJ,2017.
Evidence: [HIPP]
[IHBCE]
[TIM]
Reference(s): [3] Turnbull KJ., et al., 2017
TF binding sites (TFBSs)
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence (Confirmed, Strong, Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal HicB repressor hicAp2 1509234 1509255 -30.5 ttacacacggAGGTAAACACTAATGTTTACTTtgttgatata nd [GEA], [BPP], [SM] [3]





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