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Name: | hicAB |
Gene(s): | hicA, hicB Genome Browser M3D Gene expression COLOMBOS |
Evidence: | [ICWHO] Inferred computationally without human oversight [PAGTSBP] Products of adjacent genes in the same biological process |
Reference(s): | [1] Jorgensen MG., et al., 2009 |
Promoter | |
Name: | hicAp1 |
+1: | 1509221 |
Sigma Factor: | Sigma70 Sigmulon |
Distance from start of the gene: | 65 |
Sequence: |
cttccttcctgattttgcattgcattctgccgttgcggcgatttagtgctattttcgagcAaattacacacggaggtaaac -35 -10 +1 |
Evidence: | [TIM] |
Reference(s): | [1] Jorgensen MG., et al., 2009 |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | CRP-cAMP1 | activator | hicAp1 | 1509152 | 1509174 | -58.5 | cgcaaagaaaTTCTGGAATCTTCCTTCCTGATTttgcattgca | nd | [APIORCISFBSCS], [CV(GEA/ROMA)], [GEA] | [2] |
Note(s): | 1The gene expression of hicA was analyzed in a mutant of Sxy, a protein that is known to be a coregulator of CRP. The CRP effect on hicA expression was inferred from the results of gene expression analysis using the Sxy mutant Turnbull KJ,2017.1The gene expression of hicA was analyzed in a mutant of Sxy, a protein that is known to be a coregulator of CRP. The CRP effect on hicA expression was inferred from the results of gene expression analysis using the Sxy mutant Turnbull KJ,2017. |
Name: | hicAB |
Gene(s): | hicA, hicB Genome Browser M3D Gene expression COLOMBOS |
Note(s): | When hicAB mRNA is produced from hicAp2, only the hicB cistron is translated; that is, this mRNA produces only HicB but not the HicA protein. This happens because this transcript starts just 1 base upstream of the SD sequence of hicA Turnbull KJ,2017. The hicAB operon is induced in response to amino acid and carbon starvation Jorgensen MG,2009 |
Evidence: | [ICWHO] Inferred computationally without human oversight [PAGTSBP] Products of adjacent genes in the same biological process |
Promoter | |
Name: | hicAp2 |
+1: | 1509275 |
Sigma Factor: | Sigma70 Sigmulon |
Distance from start of the gene: | 11 |
Sequence: |
tcgagcaaattacacacggaggtaaacactaatgtttactttgttgatatactcagcggcAgggaggcgatgtgaaacaaa -35 -10 +1 |
Note(s): | The activation of the promoter hicAp2 is not affected by the Sxy protein, whereas the hicAp1 promoter is Turnbull KJ,2017. |
Evidence: |
[HIPP] [TIM] |
Reference(s): | [2] Turnbull KJ., et al., 2017 |
Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
---|---|---|---|---|---|---|---|---|---|---|
LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
proximal | HicB1 | repressor | hicAp2 | 1509234 | 1509255 | -30.5 | ttacacacggAGGTAAACACTAATGTTTACTTtgttgatata | nd | [BPP], [CV(CHIP-SV/SM)], [GEA], [SM] | [2] |
Note(s): | 1When HicA is in excess in the cell, it appears to destabilize the binding of HicB to DNA, causing the derepression of hicAB transcription Turnbull KJ,2017.1When HicA is in excess in the cell, it appears to destabilize the binding of HicB to DNA, causing the derepression of hicAB transcription Turnbull KJ,2017. |
Reference(s) |
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