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| Operon |  |
|---|---|
| Name: | dosCP |
| This page displays every known transcription unit of this operon and their known regulation. | |
| Name: | dosCP |
| Synonym(s): | yddV-dos |
| Gene(s): | dosP, dosC Genome Browser M3D Gene expression COLOMBOS |
| Note(s): | The dosCP operon is highly expressed at low growth temperatures and in the stationary phase, and it plays an important role in the expression of curli-encoding genes in aerobically growing cells |CITS: [20553324]|. The products of the dosCP operon, diguanylate cyclase (DGC) and c-di-GMP phosphodiesterase, heme-regulated (c-PDE), act as an oxygen sensor protein complex and regulate the transcription of the csgBAC operon in response to oxygen availability |CITS: [20553324]|. The dosCP operon is the most highly expressed among σS-dependent genes encoding enzymes related to c-di-GMP metabolism |CITS: [17010156][19332833]|. |
| Evidence: | [ITC] Inferred through co-regulation [LTED] Length of transcript experimentally determined |
| Reference(s): |
[1] Jonas K., et al., 2008 [2] Mendez-Ortiz MM., et al., 2006 |
| Terminator(s) | |
| Type: | rho-independent |
| Sequence: | aaatcacagtATTTAAGTGACAGTGTCACGTTAAATgaaaacccgc |
| Reference(s): | [3] Lessard IA., et al., 1998 |
| RNA cis-regulatory element | |
|---|
| Regulation, transcriptional elongation | |
| Attenuator type: | Transcriptional |
| Strand: | reverse |
| Evidence: | [ICA] Inferred by computational analysis |
| Reference(s): | [4] Merino E, et al., 2005 |
| Structure type | Energy | LeftPos | RightPos | Sequence (RNA-strand) | |
|---|---|---|---|---|---|
| terminator | -6.9 | 1567012 | 1567043 | attgccgttgCGCATGCTCATTATCTGAGTATCGAGTTTTAtcgaattgtc | |
| anti-terminator | -11.1 | 1567038 | 1567071 | tccgcccattCGTGCTAAAGCCGCGGAAATTGCCGTTGCGCATgctcattatc | |
| anti-anti-terminator | -7.6 | 1567073 | 1567102 | atgagtggacCGGACTTGTCGAACAGGCAGATCCGCCCAttcgtgctaa |
| Notes: "The provided "Sequence" is that of the RNA strand, i.e. U's are shown instead of T's and regulators on the reverse strand will appear as the reverse complement of the sequence delimited by LeftPos-RigtPos" |
| Reference(s) |
|
|---|---|
[1] Jonas K., Edwards AN., Simm R., Romeo T., Romling U., Melefors O., 2008, The RNA binding protein CsrA controls cyclic di-GMP metabolism by directly regulating the expression of GGDEF proteins., Mol Microbiol 70(1):236-57