RegulonDB RegulonDB 11.2: Operon Form
   

yqjA-mzrA operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: yqjA-mzrA
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit          
Name: yqjA-mzrA
Synonym(s): yqjAB
Gene(s): yqjA, mzrA   Genome Browser M3D Gene expression COLOMBOS
Note(s): Under NlpE outer membrane lipoprotein overexpression, the transcription of the mzrA gene is increased by CpxR Raivio TL,2013
Evidence: [COMP-AINF] Inferred computationally without human oversight
Promoter
Name: yqjAp1
+1: 3247548
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 225
Sequence: taaagtgtcagcctgtgtaaatcctctcgccaccctcccctgcattcagcaaaatcagacTccacggacatgtaattttga
                        -35                       -10       +1                   
Evidence: [COMP-AINF]
[COMP-HINF-POSITIONAL-IDENTIFICATION]
[EXP-IDA-TRANSCRIPTION-INIT-MAPPING]
Reference(s): [1] Huerta AM., et al., 2003
[2] Yamamoto K., et al., 2006
TF binding sites (TFBSs)
[CpxR,+] Phrase
Type Transcription factor Function Promoter Binding Sites Growth Conditions Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) Reference(s)
LeftPos RightPos Central Rel-Pos Sequence
proximal CpxR-phosphorylated activator yqjAp1 3247500 3247501 -47.0 agtgtcagccTgtgtaaatcc nd [COMP-HINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] nd [2]


Transcription unit       
Name: yqjA-mzrA
Gene(s): yqjA, mzrA   Genome Browser M3D Gene expression COLOMBOS
Evidence: [COMP-AINF] Inferred computationally without human oversight
Promoter
Name: yqjAp2
+1: 3247643
Sigma Factor: Sigma24 Sigmulon
Distance from start of the gene: 130
Sequence: gacctttgttacaattagattcaatttgaatttatgtttttgaatgctttcttatctcacGatttaacagggaatagttca
                                 -35                   -10  +1                   
Evidence: [COMP-AINF]
[COMP-HINF-POSITIONAL-IDENTIFICATION]
[COMP-HINF-SIMILAR-TO-CONSENSUS]
[EXP-IDA-TRANSCRIPTION-INIT-MAPPING]
Reference(s): [3] Dartigalongue C., et al., 2001
[1] Huerta AM., et al., 2003


Evidence    

 [COMP-AINF] Inferred computationally without human oversight

 [COMP-HINF-POSITIONAL-IDENTIFICATION] Human inference of promoter position

 [EXP-IDA-TRANSCRIPTION-INIT-MAPPING] Transcription initiation mapping

 [COMP-HINF-SIMILAR-TO-CONSENSUS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.

 [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] Binding of purified proteins


Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [2] Yamamoto K., Ishihama A., 2006, Characterization of copper-inducible promoters regulated by CpxA/CpxR in Escherichia coli., Biosci Biotechnol Biochem 70(7):1688-95

 [3] Dartigalongue C., Missiakas D., Raina S., 2001, Characterization of the Escherichia coli sigma E regulon., J Biol Chem 276(24):20866-75

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