RegulonDB RegulonDB 10.8: Operon Form
   

glrK operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: glrK
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit       
Name: glrK
Synonym(s): yfhK
Gene(s): glrK   Genome Browser M3D Gene expression COLOMBOS
Evidence: [ICWHO] Inferred computationally without human oversight
Promoter
Name: glrKp
+1: 2691123
Sigma Factor: Sigma70 Sigmulon
Distance from start of the gene: 25
Sequence: caaagccgggtaattcccggctttgttgtatctgaacttcccctcggttagcatcaggctAttcgcgtctgacgagagtaa
                          -35                    -10        +1                   
Note(s): The transcription of glrK is not driven by σ54 promoter, as suggested by Reitzer et al. Reitzer L,2001 instead it is driven by a σ70 promoter Reichenbach B,2009
Evidence: [CV(RS-EPT-CBR/TA)]
[CV(TA/TIM)]
[HIPP]
[RS-EPT-CBR]
[TIM]
Reference(s): [1] Reichenbach B., et al., 2009
[2] Salgado H, et al., 2012


Evidence    

 [CV(RS-EPT-CBR/TA)] cross validation(RS-EPT-CBR/TA)

 [CV(TA/TIM)] cross validation(TA/TIM)

 [HIPP] Human inference of promoter position

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [TIM] Transcription initiation mapping


Reference(s)    

 [1] Reichenbach B., Gopel Y., Gorke B., 2009, Dual control by perfectly overlapping sigma 54- and sigma 70- promoters adjusts small RNA GlmY expression to different environmental signals., Mol Microbiol 74(5):1054-70

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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