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| Operon |  |
|---|---|
| Name: | mqsRA |
| This page displays every known transcription unit of this operon and their known regulation. | |
| Name: | mqsA |
| Gene(s): | mqsA Genome Browser M3D Gene expression COLOMBOS |
| Promoter | |
| Name: | mqsAp1 |
| +1: | 3168286 |
| Sigma Factor: | Sigma70 Sigmulon |
| Distance from start of the gene: | 40 |
| Sequence: |
tggcaggatgtttacagacccaggcttgttacaggccaggtttatcttaaaattacggtaAttcatgacgtactgatcgtc -35 -10 +1 |
| Note(s): | The activity of the promoters transcribing the mqsA gene are not affected by amino acid starvation or oxidative stress Fraikin N,2019. Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 4.853. P-value: 1.177e-5 |
| Evidence: |
[ICWHO] [IEP] [TIM] |
| Reference(s): |
[1] Fraikin N., et al., 2019 [2] Huerta AM., et al., 2003 [3] Thomason MK., et al., 2015 |
| Name: | mqsA |
| Gene(s): | mqsA Genome Browser M3D Gene expression COLOMBOS |
| Promoter | |
| Name: | mqsAp2 |
| +1: | 3168397 |
| Sigma Factor: | Sigma70 Sigmulon |
| Distance from start of the gene: | 151 |
| Sequence: |
ttaaatgcagatgagttaggtttggattttgatggtatgtgtaatgttatcattggattaTcagagagcgacttttataaa -35 -10 +1 |
| Note(s): | The activity of the promoters transcribing the mqsA gene are not affected by amino acid starvation or oxidative stress Fraikin N,2019. |
| Evidence: |
[HIPP] [IEP] [TIM] |
| Reference(s): |
[1] Fraikin N., et al., 2019 [3] Thomason MK., et al., 2015 |
| Name: | mqsRA |
| Gene(s): | mqsA, mqsR Genome Browser M3D Gene expression COLOMBOS |
| Evidence: | [LTED] Length of transcript experimentally determined |
| Reference(s): |
[4] Kasari V., et al., 2010 [5] Yamaguchi Y., et al., 2009 |
| Promoter | |
| Name: | mqsRp2 |
| +1: | 3168562 |
| Sigma Factor: | Sigma70 Sigmulon |
| Distance from start of the gene: | 18 |
| Sequence: |
aactaaccttttaggtgctttttcattgctgtaattaaccttttaggttataactaaagtAacagggaggcgggggttatg -35 -10 +1 |
| Note(s): | The activity of the promoters transcribing the mqsA gene are not affected by amino acid starvation or oxidative stress Fraikin N,2019. |
| Evidence: |
[ICWHO] [TIM] |
| Reference(s): |
[6] Christensen-Dalsgaard M., et al., 2010 [2] Huerta AM., et al., 2003 [4] Kasari V., et al., 2010 |
| Name: | mqsRA | |||||||||
| Gene(s): | mqsA, mqsR Genome Browser M3D Gene expression COLOMBOS | |||||||||
| Note(s): | Transcription of mqsR was found to be induced upon biofilm formation Ren D,2004, and deletion of mqsR decreases biofilm formation and abolishes motility Gonzalez Barrios AF,2006. mqsR is more highly expressed in persister cells than nonpersisters, and overexpression of mqsR leads to growth arrest and increased tolerance to certain antibiotics 16768798. Zhang XS,2008. In addition, the toxins Hha, HokA, and CspD, the outer membrane proteins OppA and YbfM, and small RNA regulator Hfq are involved during persister cell formation via MqsR overexpression 19909729 Coinduction of mqsA expression rescues cell growth Yamaguchi Y,2009. Christensen-Dalsgaard M,2010. However, the opposite effect has also been reported Zhang XS,2008. | |||||||||
| Evidence: | [ICWHO] Inferred computationally without human oversight [LTED] Length of transcript experimentally determined |
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| Reference(s): | [5] Yamaguchi Y., et al., 2009 | |||||||||
| Promoter | ||||||||||
| Name: | mqsRp | |||||||||
| +1: | 3168653 | |||||||||
| Sigma Factor: | Sigma70 Sigmulon | |||||||||
| Distance from start of the gene: | 109 | |||||||||
| Sequence: |
caaactggcgctactaatgcgccactttcttatatggtcaatcactttccttaaagaataCgttttgtgtggtcactatct -35 -10 +1 |
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| Note(s): | The activity of the promoters transcribing the mqsA gene are not affected by amino acid starvation or oxidative stress Fraikin N,2019. | |||||||||
| Evidence: |
[ICWHO] [TIM] |
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| Reference(s): |
[2] Huerta AM., et al., 2003 [5] Yamaguchi Y., et al., 2009 |
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| Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
| remote | MqsA | repressor | mqsRp | 3168573 | 3168587 | 74.0 | attgctgtaaTTAACCTTTTAGGTTAtaactaaagt | nd | [APIORCISFBSCS], [BPP], [GEA], [IHBCE] | [1], [5] |
| remote | MqsA | repressor | mqsRp | 3168605 | 3168619 | 42.0 | gtacatctaaCTAACCTTTTAGGTGCtttttcattg | nd | [APIORCISFBSCS], [BPP], [GEA], [IHBCE] | [1], [5] |
| RNA cis-regulatory element | |
|---|
| Regulation, transcriptional elongation | |
| Attenuator type: | Transcriptional |
| Strand: | reverse |
| Structure type | Energy | LeftPos | RightPos | Sequence (RNA-strand) | |
|---|---|---|---|---|---|
| terminator | -10.2 | 3168683 | 3168708 | tgcttcaaacTGGCGCTACTAATGCGCCACTTTCTtatatggtca | |
| anti-terminator | -5.17 | 3168704 | 3168748 | gttggcgtgaTGCCTGACTCCAGCTTCCCTTATAAATTCCTGCTTCAAACTGGCgctactaatg | |
| anti-anti-terminator | -5.8 | 3168735 | 3168758 | tttatgtgccGTTGGCGTGATGCCTGACTCCAGcttcccttat |
| Notes: "The provided "Sequence" is that of the RNA strand, i.e. U's are shown instead of T's and regulators on the reverse strand will appear as the reverse complement of the sequence delimited by LeftPos-RigtPos" |
| Reference(s) |
|
|---|---|
[ICWHO] Inferred computationally without human oversight