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| Operon |  |
|---|---|
| Name: | appCBXA |
| This page displays every known transcription unit of this operon and their known regulation. | |
| Name: | appCBA-yccB |
| Synonym(s): | OP00137, appCBA, cyx-appA, cyxAB-appA |
| Gene(s): | appC, appB, appX, appA Genome Browser M3D Gene expression COLOMBOS |
| Evidence: | [ITC] Inferred through co-regulation [PM] Polar mutation |
| Reference(s): |
[1] Atlung T., et al., 1994 [2] Dassa J., et al., 1991 |
| Promoter | |
| Name: | appCp |
| +1: | 1037710 |
| Sigma Factor: | Sigma70, Sigma38 |
| Distance from start of the gene: | 30 |
| Sequence: |
ggcgaatacctctggtcgtagagtttcaggataaagagggagatctaccattatcgggttAtttttctctcttcgcctaca -35 -10 +1 |
| Evidence: | [HIPP] |
| Reference(s): |
[1] Atlung T., et al., 1994 [3] Atlung T., et al., 1997 [2] Dassa J., et al., 1991 |
| Type | Transcription factor | Function | Promoter | Binding Sites | Growth Conditions | Evidence (Confirmed, Strong, Weak) | Reference(s) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| LeftPos | RightPos | Central Rel-Pos | Sequence | |||||||
| proximal | YdeO | activator | appCp | 1037672 | 1037694 | -27.5 | tggtcgtagaGTTTCAGGATAAAGAGGGAGATCtaccattatc | nd | [BPP], [CV(GEA)], [CV(GEA)], [GEA], [IHBCE] | [4] |
| Note(s): |
1The AppY protein is also involved in anaerobic induction of the hya operon, which encodes hydrogenase 1 and is located immediately upstream from the appCBA operon. The AppY protein regulates AppA synthesis by activating transcription from the appCp promoter. Furthermore, the appY gene might be autoregulated. Genetic analysis of the appCp promoter region indicates that the presence of sequences upstream from the -10 region are required for activation of the appCp promoter by AppY protein and anaerobiosis, suggesting that this region has an AppY-binding site.2The AppY protein is also involved in anaerobic induction of the hya operon, which encodes hydrogenase 1 and is located immediately upstream from the appCBA operon. The AppY protein regulates AppA synthesis by activating transcription from the appCp promoter. Furthermore, the appY gene might be autoregulated. Genetic analysis of the appCp promoter region indicates that the presence of sequences upstream from the -10 region are required for activation of the appCp promoter by AppY protein and anaerobiosis, suggesting that this region has an AppY-binding site. |
| Name: | appA | ||||
| Gene(s): | appA Genome Browser M3D Gene expression COLOMBOS | ||||
| Reference(s): | [1] Atlung T., et al., 1994 | ||||
| Promoter | |||||
| Name: | appAp | ||||
| +1: | 1040599 | ||||
| Distance from start of the gene: | 18 | ||||
| Sequence: |
| Evidence: |
[HIPP] |
[TIM] Reference(s): |
[2] Dassa J., et al., 1991
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| Reference(s) |
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[HIPP] Human inference of promoter position