RegulonDB RegulonDB 10.8: Operon Form
   

micL operon and associated TUs in Escherichia coli K-12 genome




Operon      
Name: micL
This page displays every known transcription unit of this operon and their known regulation.


Transcription unit       
Name: micL
Synonym(s): slrA
Gene(s): micL   Genome Browser M3D Gene expression COLOMBOS
Evidence: [LTED] Length of transcript experimentally determined
Reference(s): [1] Guo MS., et al., 2014
[2] Updegrove TB., et al., 2019
Promoter
Name: micLp
+1: 1958747
Sigma Factor: Sigma24 Sigmulon
Distance from start of the gene: 227
Sequence: gcactgcaaggtttatcaaaaattatggaacttattgcccatcgtgatgctccaatcattAtggccggagcaggagtccgt
                            -35                    -10      +1                   
Evidence: [CV(RS-EPT-CBR)]
[CV(TIM)]
[RS-EPT-CBR]
[TIM]
Reference(s): [3] Klein G., et al., 2014
[4] Salgado H, et al., 2012


Transcription unit       
Name: micL
Gene(s): micL   Genome Browser M3D Gene expression COLOMBOS
Evidence: [BTEI] Boundaries of transcription experimentally identified
Reference(s): [5] Dartigalongue C., et al., 2001
Promoter
Name: micLp2
+1: 1958986
Distance from start of the gene: 466
Sequence: ccattcttgaggatgtgcgcacggtccgcgaattaggttttcctggactggtgacgggcgTtctcgatgttgacgggaatg
Evidence: [HIPP]
[TIM]
Reference(s): [5] Dartigalongue C., et al., 2001
[6] Gupta SD., et al., 1995




Reference(s)    

 [1] Guo MS., Updegrove TB., Gogol EB., Shabalina SA., Gross CA., Storz G., 2014, MicL, a new σE-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein., Genes Dev 28(14):1620-34

 [2] Updegrove TB., Kouse AB., Bandyra KJ., Storz G., 2019, Stem-loops direct precise processing of 3' UTR-derived small RNA MicL., Nucleic Acids Res 47(3):1482-1492

 [3] Klein G., Kobylak N., Lindner B., Stupak A., Raina S., 2014, Assembly of lipopolysaccharide in Escherichia coli requires the essential LapB heat shock protein., J Biol Chem 289(21):14829-53

 [4] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [5] Dartigalongue C., Missiakas D., Raina S., 2001, Characterization of the Escherichia coli sigma E regulon., J Biol Chem 276(24):20866-75

 [6] Gupta SD., Lee BT., Camakaris J., Wu HC., 1995, Identification of cutC and cutF (nlpE) genes involved in copper tolerance in Escherichia coli., J Bacteriol 177(15):4207-15


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