![]() ![]() |
Synonyms: TyrR, TyrR-L-tyrosine, TyrR-L-phenylalanine, TyrR-L-tryptophan |
Summary:
TyrR, "tyrosine repressor," is the dual transcriptional regulator of the TyrR regulon [28, 29, 30] The TyrR regulon involves genes that are essential for aromatic amino acid biosynthesis and transport. TyrR can act both as a repressor and as an activator of transcription at σ70-dependent promoters [26] TyrR is a homodimer in solution. In the presence of tyrosine and ATP it self-associates to form a hexamer [31, 32] TyrR consists of three functional domains, an N-terminal domain (aa 1-190), a central domain (aa 206-433), and a C-terminal domain (aa 444-513). The structure of the N-terminal domain has been solved [33] It contains both an ACT and a PAS domain and is responsible for the activation functions of TyrR. The central domain carries an AAA+ domain typical for enhancer-binding proteins [34] This domain is responsible for the binding and hydrolysis of ATP and for the ATP-dependent binding of the aromatic amino acid cofactors. Read more > |
Transcription factor | ![]() ![]() |
||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TF conformation(s): |
|
||||||||||||||||||||||||||||||
Evolutionary Family: | EBP | ||||||||||||||||||||||||||||||
Sensing class: | Sensing external and internal signals | ||||||||||||||||||||||||||||||
Connectivity class: | Local Regulator | ||||||||||||||||||||||||||||||
Gene name: | tyrR | ||||||||||||||||||||||||||||||
Genome position: | 1386720-1388261 | ||||||||||||||||||||||||||||||
Length: | 1542 bp / 513 aa | ||||||||||||||||||||||||||||||
Operon name: | ycjXF-tyrR | ||||||||||||||||||||||||||||||
TU(s) encoding the TF: |
|
Regulon |
![]() ![]() |
||||||
---|---|---|---|---|---|---|---|
Regulated gene(s) | aroF, aroG, aroL, aroM, aroP, folA, mtr, tyrA, tyrB, tyrP, tyrR, yaiA | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
phenylalanine (4)
tyrosine (4)
Porters (Uni-, Sym- and Antiporters) (3)
membrane (3)
chorismate (2)
Read more >
|
||||||
Regulated operon(s) | aroF-tyrA, aroG, aroL-yaiA-aroM, aroP, folA, mtr, tyrB, tyrP, ycjXF-tyrR | ||||||
First gene in the operon(s) | aroF, aroG, aroL, aroP, folA, mtr, tyrB, tyrP, tyrR | ||||||
Simple and complex regulons | CpxR,TyrR Cra,TyrR HU,IHF,TrpR,TyrR HU,IHF,TyrR IHF,TyrR Read more > | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Transcription factor regulation |
![]() |
---|
Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
TyrR-L-tyrosine | repressor | aroFp | Sigma70 | -104.5 | -155.5 | aroF, tyrA |
tcaaagggagTGTAAATTTATCTATACAgaggtaaggg
|
2741297 | 2741314 | [GEA], [APIORCISFBSCS], [SM] | [2], [3], [4] | |
TyrR-L-tyrosine | repressor | aroFp | Sigma70 | -52.5 | -103.5 | aroF, tyrA |
aaattgcctgTGTAAATAAAAATGTACGaaatatggat
|
2741245 | 2741262 | [GEA], [APIORCISFBSCS], [SM] | [2], [3], [4] | |
TyrR-L-tyrosine | repressor | aroFp | Sigma70 | -29.5 | -80.5 | aroF, tyrA |
gtacgaaataTGGATTGAAAACTTTACTttatgtgtta
|
2741222 | 2741239 | [GEA], [APIORCISFBSCS], [SM] | [2], [3], [4], [5] | |
TyrR-L-phenylalanine | repressor | aroGp | Sigma70 | -38.0 | -80.0 | aroG |
tccgttcataGTGTAAAACCCCGTTTACacattctgac
|
785544 | 785561 | [APIORCISFBSCS], [BPP], [SM] | [6] | |
TyrR-L-tyrosine | repressor | aroLp1 | Sigma70 | -45.0 | -170.0 | aroL, yaiA, aroM |
tggctaaatgTAATTTATTATTTACACTtcattcttga
|
406226 | 406243 | [GEA], [BPP], [SM] | [1], [5], [7] | |
TyrR-L-tyrosine | repressor | aroLp1 | Sigma70 | 12.0 | -114.0 | aroL, yaiA, aroM |
aggggtgtatTGAGATTTTCACTTTAAGtggaattttt
|
406282 | 406299 | [GEA], [BPP], [SM] | [1], [5], [7] | |
TyrR-L-tyrosine | repressor | aroLp1 | Sigma70 | 31.0 | -95.0 | aroL, yaiA, aroM |
cactttaagtGGAATTTTTTCTTTACAAtcgaaattgt
|
406301 | 406318 | [GEA], [BPP], [SM] | [1], [5], [7] | |
TyrR-L-tyrosine | repressor | aroPp1 | Sigma70 | 40.5 | -80.5 | aroP |
aacttctttgATGTAAACAAATTAATACaacaaacgga
|
121623 | 121640 | [GEA], [APIORCISFBSCS], [BPP], [SM] | [8], [9], [10], [11], [12], [13] | |
TyrR-L-tyrosine | repressor | aroPp1 | Sigma70 | 63.5 | -57.5 | aroP |
aatacaacaaACGGAATTGCAAACTTACacacgcatca
|
121600 | 121617 | [GEA], [APIORCISFBSCS], [BPP], [SM] | [8], [9], [10], [11], [12], [13] | |
TyrR-L-tyrosine | repressor | aroPp2 | Sigma70 | 19.5 | -80.5 | aroP |
aacttctttgATGTAAACAAATTAATACaacaaacgga
|
121623 | 121640 | [GEA], [APIORCISFBSCS], [BPP], [SM] | [8], [9], [12], [13] | |
TyrR-L-tyrosine | repressor | aroPp2 | Sigma70 | 42.5 | -57.5 | aroP |
aatacaacaaACGGAATTGCAAACTTACacacgcatca
|
121600 | 121617 | [GEA], [APIORCISFBSCS], [BPP], [SM] | [8], [9], [10], [11], [12], [13] | |
TyrR-L-tyrosine | activator | folAp | Sigma70 | -148.5 | -172.5 | folA |
taaagagtgaCGTAAATCACACTTTACAgctaactgtt
|
49642 | 49659 | [GEA], [APIORCISFBSCS], [BPP], [SM] | [14] | |
TyrR-L-tyrosine | activator | folAp | Sigma70 | -106.0 | -130.0 | folA |
tttgtttcatTGTAATGCGGCGAGTCCAgggagagagc
|
49684 | 49701 | [GEA], [APIORCISFBSCS], [BPP], [SM] | [14] | |
TyrR-L-tyrosine | activator | mtrp2 | Sigma70 | -106.5 | -149.5 | mtr |
ggtggtgatgCGTAATCATCGCTGAACAgcgaacacaa
|
3305958 | 3305975 | [GEA], [APIORCISFBSCS], [BPP], [SM] | [15], [16], [17] | |
TyrR-L-tyrosine | activator | mtrp2 | Sigma70 | -76.5 | -119.5 | mtr |
gaacacaatcTGTAAAATAATATATACAgccccgattt
|
3305928 | 3305945 | [GEA], [APIORCISFBSCS], [BPP], [SM] | [15], [16], [17], [18] | |
TyrR-L-tyrosine | repressor | tyrBp | Sigma70 | 19.5 | -13.5 | tyrB |
accacctgccCGTAAACCTGGAGAACCAtcgcgtgttt
|
4267092 | 4267109 | [GEA], [APIORCISFBSCS], [BPP], [SM] | [19], [20] | |
TyrR-L-tyrosine | repressor | tyrBp | Sigma70 | 42.5 | 10.5 | tyrB |
aaccatcgcgTGTTTCAAAAAGTTGACGcctacgctgg
|
4267115 | 4267132 | [GEA], [APIORCISFBSCS], [BPP], [SM] | [19], [20] | |
TyrR | repressor | tyrPp1 | Sigma70 | -64.5 | -100.5 | tyrP |
tgctttttatTGTACATTTATATTTACAccatatgtaa
|
1989572 | 1989589 | [GEA], [BCE], [BPP], [SM] | [21], [22], [23], [24] | |
TyrR-L-phenylalanine | activator | tyrPp1 | Sigma70 | -64.5 | -100.5 | tyrP |
tgctttttatTGTACATTTATATTTACAccatatgtaa
|
1989572 | 1989589 | [GEA], [BCE], [BPP], [SM] | [21], [22], [23], [24] | |
TyrR-L-tyrosine | repressor | tyrPp1 | Sigma70 | -41.5 | -77.5 | tyrP |
ttacaccataTGTAACGTCGGTTTGACGaagcagccgt
|
1989595 | 1989612 | [GEA], [BCE], [BPP], [SM] | [21], [22], [23], [24] | |
TyrR | repressor | tyrRp | Sigma70 | -95.5 | -123.5 | tyrR |
tatcgggtgcTGACCGGATATCTTTACGccgaagtgcc
|
1386588 | 1386605 | [GEA], [APIORCISFBSCS] | [25], [26] | |
TyrR | repressor | tyrRp | Sigma70 | -51.5 | -79.5 | tyrR |
tccgtctttgTGTCAATGATTGTTGACAgaaaccttcc
|
1386632 | 1386649 | [GEA], [APIORCISFBSCS] | [25], [27] |
Alignment and PSSM for TyrR TFBSs | ![]() |
---|
Aligned TFBS of TyrR |
---|
Sequence | |
---|---|
TGTATAGATAAATTTACACTC | |
TGTACATTTATATTTACACCA | |
TGTAAAACCCCGTTTACACAT | |
TGTAATTTATTATTTACACTT | |
TGTATATATTATTTTACAGAT | |
CGTAAATCACACTTTACAGCT | |
TGTATTAATTTGTTTACATCA | |
CGTACATTTTTATTTACACAG | |
TGTAAAGAAAAAATTCCACTT | |
TGTTCAGCGATGATTACGCAT | |
TGTCAATGATTGTTGACAGAA | |
TGTTTCAAAAAGTTGACGCCT | |
TGGATTGAAAACTTTACTTTA | |
CGGAATTGCAAACTTACACAC | |
TGACCGGATATCTTTACGCCG | |
CGTCAAACCGACGTTACATAT | |
TGGTTCTCCAGGTTTACGGGC | |
TGTATTGAGATTTTCACTTTA | |
TGTAATGCGGCGAGTCCAGGG |
Position weight matrix (PWM). TyrR matrix-quality result |
---|
A 0 0 1 13 8 10 4 8 6 10 8 6 3 0 0 17 0 13 0 7 5 C 4 0 0 3 4 2 0 6 4 2 2 4 1 0 1 2 19 0 10 5 3 G 0 19 3 0 0 1 7 2 3 2 1 7 1 1 2 0 0 4 5 2 3 T 15 0 15 3 7 6 8 3 6 5 8 2 14 18 16 0 0 2 4 5 8 |
Consensus |
---|
; consensus.strict tGtaaagcaaagtTTACacct ; consensus.strict.rc AGGTGTAAACTTTGCTTTACA ; consensus.IUPAC yGtahwkmhawvtTTACrsmt ; consensus.IUPAC.rc AKSYGTAAABWTDKMWDTACR ; consensus.regexp [ct]Gta[act][at][gt][ac][act]a[at][acg]tTTAC[ag][cg][ac]t ; consensus.regexp.rc A[GT][CG][CT]GTAAA[CGT][AT]T[AGT][GT][AC][AT][AGT]TAC[AG] |
Evolutionary conservation of regulatory elements | ![]() |
---|