RegulonDB RegulonDB 10.9:Regulon Page
   

FNR DNA-binding transcriptional dual regulator

Synonyms: FNR, FNR-[4Fe-4S]2+ reduced, FNR-[2Fe-2S]2+ oxidized
Summary:
FNR is the primary transcriptional regulator that mediates the transition from aerobic to anaerobic growth through the regulation of hundreds of genes. Generally, this protein activates genes involved in anaerobic metabolism and represses genes involved in aerobic metabolism [8, 91]. FNR also regulates the transcription of many genes with other functions, such as acid resistance, chemotaxis, cell structure, and molecular biosynthesis, among others [8, 91]. The cellular concentration of FNR is similar under both anaerobic and aerobic growth [], but its activity is regulated directly by oxygen. Under anaerobiosis, FNR acquires a [4Fe-4S] cluster that causes a conformational change and dimerization of the protein that causes it to become activated []. Purification of [4Fe-4S]-FNR in an O2-free environment has been described [].
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Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
FNR Functional   [APPHINH], [HIFS] [1], [2], [3], [4]
FNR-[2Fe-2S]2+ oxidized Non-Functional Covalent Apo nd nd
FNR-[4Fe-4S]2+ reduced Functional Covalent Holo nd nd
Evolutionary Family: CRP
Sensing class: Using internal synthesized signals
Connectivity class: Global Regulator
Gene name: fnr
  Genome position: 1398774-1399526
  Length: 753 bp / 250 aa
Operon name: fnr
TU(s) encoding the TF:
Transcription unit        Promoter
fnr
fnrp


Regulon       
Regulated gene(s) aceE, aceF, ackA, acnA, acrE, acrF, adhE, aer, aldA, amtB, ansB, arcA, aspA, aspC, bcsB, bcsZ, cadC, caiA, caiB, caiC, caiD, caiE, caiF, caiT, ccmA, ccmB, ccmC, ccmD, ccmE, ccmF, ccmG, ccmH, ccp, cheB, cheR, cheY, cheZ, citC, citD, citE, citF, citG, citX, cydA, cydB, cydC, cydD, cyoA, cyoB, cyoC, cyoD, cyoE, cysG, dcuA, dcuB, dcuC, dcuR, dcuS, dmsA, dmsB, dmsC, dmsD, dpiA, dpiB, dppA,
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Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
membrane (79)
anaerobic respiration (67)
aerobic respiration (27)
electron donors (26)
electron acceptors (24)
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Regulated operon(s) ackA-pta, acrEF, adhE, aer, aldA, ansB, arcA, aspA-dcuA, aspC, bcsABZC, cadC, caiF, caiTABCDE, ccp, citCDEFXG, cydAB, cydDC, cyoABCDE, dcuB-fumB, dcuC, dcuSR, dmsABC, dpiBA, dppABCDF, emrKY, fdhF, fdnGHI, feoABC, fes-ybdZ-entF-fepE, fixABCX, fnr, fnrS, focA-pflB, frdABCD, fumAC, gadAXW, garPLRK-rnpB, gcvTHP, gdhA, glnK-amtB, glpABC, glpTQ, gltBDF, gnd, grcA, hcp-hcr-poxB-ltaE-ybjT, hemA-prfA-prmC, hlyE, hmp, hyfABCDEFGHIJR-focB, hypABCDE-fhlA, iraM, katG, malPQ, map-glnD-dapD, moaABCDE, moeAB, nac, napFDAGHBC-ccmABCDEFGH, narGHJI, narK, narXL, ndh, nfeR, nikABCDER,
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First gene in the operon(s) aceE, ackA, acnA, acrE, adhE, aer, aldA, ansB, arcA, aspA, aspC, bcsB, cadC, caiF, caiT, citC, cydA, cydD, cyoA, dcuB, dcuC, dcuS, dmsA, dpiB, dppA, emrK, fdhF, fdnG, feoA, fes, fixA, fnr, fnrS, focA, frdA, fumA, fumB, fumC, gadA, gadX, garP, gcvT, gdhA, glnD, glnK, glpA, glpT, gltB, gnd, grcA, hcp, hemA, hlyE, hmp, hyfA, hypB, idlP, iraM, katG, lpd, malP, moaA, moeA, nac, napF,
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Simple and complex regulons AcrR,FNR,Fur,SoxR
AcrR,FNR,Fur,SoxR,SoxS
AdiY,ArcA,CRP,FNR,Fis,GadE-RcsB,GadW,GadX,H-NS,RcsB,TorR
AdiY,ArcA,CRP,FNR,Fis,GadE-RcsB,GadW,GadX,H-NS,RcsB,TorR,ppGpp
AdiY,ArgR,CRP,FNR,Fur,GadE,HdfR,IHF,Lrp,Nac
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Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)
[FNR,-](59)
[FNR,+](79)


Transcription factor regulation    


Transcription factor binding sites (TFBSs) arrangements
      

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  FNR repressor aceEp Sigma70 nd nd aceE, aceF
nd
 nd nd [BPP], [GEA], [IGI] [5], [6]
  FNR repressor aceEp2 Sigma38 nd nd aceE, aceF
nd
 nd nd [BPP], [GEA], [IGI] [5], [6]
  FNR activator ackAp Sigma32 nd nd ackA
nd
 nd nd [BPP], [GEA], [IGI] [6]
  FNR repressor acnAp2 Sigma70 -40.5 -90.5 acnA
tttatcaattTGGGTTGTTATCAAAtcgttacgcg
 1335734 1335747 [APIORCISFBSCS], [GEA] [7]
  FNR activator acrEp Sigma70 nd nd acrE, acrF
nd
 nd nd [BPP], [GEA], [IGI] [8]
  FNR activator adhEp2 Sigma38 -42.5 -230.5 adhE
tttgcaaaaaTTTGATTTGGATCACgtaatcagta
 1298345 1298358 [APIORCISFBSCS], [GEA] [9]
  FNR activator aerp Sigma28 -49.5 -93.5 aer
aatcgcaaatTGCGATCTAAATCAAattaatcggt
 3219163 3219176 [AIBSCS], [GEA] [10]
  FNR repressor aldAp Sigma70 -10.5 -52.5 aldA
tctctgatgaTTGATGTTAATTAACaatgtattca
 1488173 1488186 [AIBSCS], [GEA] [10]
  FNR activator ansBp2 Sigma70 -41.5 -64.5 ansB
cacgttgtaaATTGTTTAACGTCAAatttcccata
 3100786 3100799 [BCE], [SM]
  FNR activator arcAp1 Sigma70 -82.5 -284.5 arcA
tacaattgaaCTTGATATATGTCAAcgaagcgtag
 4640584 4640597 [APIORCISFBSCS], [GEA] [11]
  FNR repressor arcAp3 Sigma70 -55.5 -284.5 arcA
tacaattgaaCTTGATATATGTCAAcgaagcgtag
 4640584 4640597 [APIORCISFBSCS], [GEA] [11], [12]
  FNR activator aspAp Sigma70 -40.5 -145.5 aspA, dcuA
cgacacttaaAGTGATCCAGATTACggtagaaatc
 4368466 4368479 [APIORCISFBSCS], [GEA] [13]
  FNR activator aspCp nd nd nd aspC
nd
 nd nd [BPP], [GEA], [IGI] [12]
  FNR repressor aspCp nd nd nd aspC
nd
 nd nd [BPP], [GEA], [IGI] [12]
  FNR activator bcsBp Sigma70 nd nd bcsB, bcsZ
nd
 nd nd [BPP], [GEA], [IGI] [8]
  FNR activator cadCp Sigma70 -156.5 -185.5 cadC
gatgatgaatTTTGATGGTAAGGAAtattacttct
 4362113 4362126 [AIBSCS], [GEA] [10]
  FNR activator caiFp Sigma70 -55.5 -137.5 caiF
atcgatatttTTGATGACATAAGCAggatttagct
 34156 34169 [BCE], [GEA] [14]
  FNR activator caiTp Sigma70 -90.5 -196.5 caiT, caiA, caiB, caiC, caiD, caiE
caaactgattATTAATCAAAATTAAcgaaaaaacg
 42121 42134 [AIBSCS], [GEA] [8], [10]
  FNR activator caiTp Sigma70 -41.5 -147.5 caiT, caiA, caiB, caiC, caiD, caiE
gaaacaaaaaTGTGATACCAATCACagaatacagc
 42072 42085 [AIBSCS], [GEA] [8], [10]
  FNR repressor citCp2 nd 11.5 -172.5 citC, citD, citE, citF, citX, citG
actaactctaTGTGAAATAAATCAAaatttcacgc
 652022 652035 [AIBSCS], [AIBSCS] [15]
  FNR repressor cydAp1 Sigma70 -53.5 -341.5 cydA, cydB
tttgtaggaaTTGATATTTATCAATgtataagtct
 771110 771123 [AIBSCS], [BPP], [GEA] [8], [16], [17], [18], [19], [20], [21]
  FNR repressor cydAp1 Sigma70 -1.5 -289.5 cydA, cydB
aagagataaaTTGTTCTCGATCAAAttggctgaaa
 771162 771175 [APIORCISFBSCS], [BPP], [GEA] [8], [16], [17], [19], [20], [21]
  FNR activator cydAp2 Sigma70 -167.5 -341.5 cydA, cydB
tttgtaggaaTTGATATTTATCAATgtataagtct
 771110 771123 [AIBSCS], [BPP], [GEA] [8], [19], [21]
  FNR repressor cydAp2 Sigma70 -115.5 -289.5 cydA, cydB
aagagataaaTTGTTCTCGATCAAAttggctgaaa
 771162 771175 [APIORCISFBSCS], [BPP], [GEA] [8], [19], [21]
  FNR repressor cydAp3 Sigma70 -85.5 -341.5 cydA, cydB
tttgtaggaaTTGATATTTATCAATgtataagtct
 771110 771123 [AIBSCS], [BPP], [GEA] [8], [19], [21]
  FNR repressor cydAp3 Sigma70 -33.5 -289.5 cydA, cydB
aagagataaaTTGTTCTCGATCAAAttggctgaaa
 771162 771175 [APIORCISFBSCS], [BPP], [GEA] [8], [19], [21]
  FNR repressor cydAp4 Sigma70 -96.5 -341.5 cydA, cydB
tttgtaggaaTTGATATTTATCAATgtataagtct
 771110 771123 [AIBSCS], [BPP], [GEA] [8], [19], [21]
  FNR repressor cydAp4 Sigma70 -44.5 -289.5 cydA, cydB
aagagataaaTTGTTCTCGATCAAAttggctgaaa
 771162 771175 [APIORCISFBSCS], [BPP], [GEA] [8], [19], [21]
  FNR activator cydDp Sigma70 -90.5 -159.5 cydD, cydC
catggcagcaCTTGATGCGGAACGCtacctcgatg
 931115 931128 [APIORCISFBSCS], [GEA] [22]
  FNR repressor cyoAp Sigma70 -192.5 -235.5 cyoA, cyoB, cyoC, cyoD, cyoE
tttgttaaatAATTGTTTTATTTCAcattggttat
 451839 451852 [AIBSCS], [GEA] [8], [10], [12], [13], [16]
  FNR activator dcuBp Sigma70 -45.5 -65.5 dcuB, fumB
tctgaaaacaGTTCATACAAAACAGaacgtgactg
 4348803 4348816 [APIORCISFBSCS], [GEA] [23]
  FNR activator dcuCp nd -115.5 -230.5 dcuC
agctaacaccATTGCAATTAACAAAtttgcatcaa
 656192 656205 [APIORCISFBSCS], [GEA] [24]
  FNR activator dcuCp nd -63.5 -178.5 dcuC
cacattattaTGTGATAATTGCCAAccgctaaata
 656140 656153 [APIORCISFBSCS], [GEA] [24]
  FNR activator dcuCp nd -33.5 -148.5 dcuC
aaatatgcgtTTTGTTATCTATGTAtaaaaacagc
 656110 656123 [APIORCISFBSCS], [GEA] [24]
  FNR activator dcuSp Sigma70 nd nd dcuS, dcuR
nd
 nd nd [BPP], [GEA], [IGI] [8]
  FNR activator dmsAp1 Sigma70 -41.5 -177.5 dmsA, dmsB, dmsC
ttgtctccctTTGATACCGAACAATaattactcct
 940775 940788 [BCE], [BPP], [GEA], [SM] [25], [26], [27]
  FNR repressor dpiBp nd 45.5 -206.5 dpiB, dpiA
gcgtgaaattTTGATTTATTTCACAtagagttagt
 652022 652035 [AIBSCS] [15]
  FNR repressor dppAp Sigma70 -162.5 -327.5 dppA, dppB, dppC, dppD, dppF
atcaccaaatGTTGCTAAATATTAAgctgattgtt
 3708026 3708039 [AIBSCS], [GEA] [10]
  FNR activator emrKp nd nd nd emrK, emrY
nd
 nd nd [BPP], [GEA], [IGI] [8]
  FNR activator fdhFp Sigma54 nd nd fdhF
nd
 nd nd [BPP], [GEA], [IGI] [8]
  FNR activator fdnGp Sigma70 -97.5 -126.5 fdnG, fdnH, fdnI
tctaccgctaTTGAGGTAGGTCAATttgcgaaggc
 1547268 1547281 [APIORCISFBSCS], [GEA], [SM] [28]
  FNR repressor fdnGp Sigma70 -97.5 -126.5 fdnG, fdnH, fdnI
tctaccgctaTTGAGGTAGGTCAATttgcgaaggc
 1547268 1547281 [APIORCISFBSCS], [GEA], [SM] [28]
  FNR activator fdnGp Sigma70 -42.5 -71.5 fdnG, fdnH, fdnI
gatgttctttTTGATTTCGCGCAAAaagattcaga
 1547323 1547336 [APIORCISFBSCS], [GEA], [SM] [28]
  FNR activator feoAp Sigma70 -90.5 -196.5 feoA, feoB, feoC
gctgcgatatAACCTTGAGCCACATCAACATTGagtcagatta
 3539956 3539978 [APIORCISFBSCS], [GEA] [29]
  FNR activator fesp Sigma70 -143.5 -193.5 fes, ybdZ, entF, fepE
aactgtcgggCATGGTCGTCATCAAcacgacgcat
 612537 612550 [AIBSCS], [GEA] [10]
  FNR activator fixAp Sigma70 -197.5 -275.5 fixA, fixB, fixC, fixX
cgttttttcgTTAATTTTGATTAATaatcagtttg
 42121 42134 [AIBSCS], [GEA] [8], [10]
  FNR activator fnrSp Sigma70 -42.5 -42.5 fnrS
gccgcaaagtTTGAGCGAAGTCAATaaactctcta
 1409080 1409093 [APIORCISFBSCS], [BPP], [GEA] [30]
  FNR repressor fnrp Sigma70 -0.5 -26.5 fnr
agatgttaaaATTGACAAATATCAAttacggcttg
 1399546 1399559 [APIORCISFBSCS], [BCE], [BPP], [GEA] [3]
  FNR activator focAp1 Sigma70 -40.5 -67.5 focA, pflB
ccaggcgagaTATGATCTATATCAAtttctcatct
 954527 954540 [APIORCISFBSCS], [BCE], [GEA], [SM] [31]
  FNR activator focAp3 Sigma70 -58.5 -406.5 focA, pflB
agcattctggGCAAAATAAAATCAAatagcctacg
 954866 954879 [BCE], [GEA], [SM] [31]
  FNR activator frdAp Sigma70 -45.5 -139.5 frdA, frdB, frdC, frdD
cactaaaaaaATCGATCTCGTCAAAtttcagactt
 4382451 4382464 [BCE], [GEA] [6], [32], [33], [34]
  FNR activator frdAp2 Sigma38 -45.5 -139.5 frdA, frdB, frdC, frdD
cactaaaaaaATCGATCTCGTCAAAtttcagactt
 4382451 4382464 [BCE], [GEA] [6], [32], [33], [34]
  FNR repressor fumAp Sigma70 nd nd fumA, fumC
nd
 nd nd [BPP], [GEA], [IGI] [35]
  FNR activator fumBp Sigma70 -114.5 -136.5 fumB
ttctgccgggGTTGATTGGTGTGAGcgtatcgtgc
 4347456 4347469 [BCE], [GEA] [13], [36], [37]
  FNR activator fumBp Sigma70 -61.5 -83.5 fumB
gccgcgatgtACGGGTTCTTATAAAtgcactttgc
 4347403 4347416 [BCE], [GEA] [36], [37]
  FNR activator fumBp Sigma70 -57.5 -79.5 fumB
cgatgtacggGTTCTTATAAATGCActttgcgtgc
 4347399 4347412 [BCE], [GEA] [36], [37]
  FNR repressor fumCp Sigma38 nd nd fumC
nd
 nd nd [BPP], [GEA], [IGI] [12]
  FNR repressor gadAp Sigma70 11.5 -16.5 gadA, gadX
tttattgcctTCAAATAAATTTAAGgagttcgaaa
 3667590 3667603 [AIBSCS], [GEA] [10]
  FNR repressor gadAp2 Sigma38 11.5 -16.5 gadA, gadX
tttattgcctTCAAATAAATTTAAGgagttcgaaa
 3667590 3667603 [AIBSCS], [GEA] [10]
  FNR repressor gadXp Sigma38 -159.5 -188.5 gadX, gadW
aaagggattaTTTGCTTACTATTAAtttccctgtg
 3665992 3666005 [AIBSCS], [GEA] [10]
  FNR activator garPp Sigma70 nd nd garP, garL, garR, garK, rnpB
nd
 nd nd [BPP], [GEA], [IGI] [10]
  FNR activator gcvTp Sigma70 nd nd gcvT, gcvH, gcvP
nd
 nd nd [BPP], [GEA], [IGI] [8]
  FNR activator gdhAp1 Sigma70 nd nd gdhA
nd
 nd nd [BPP], [GEA], [IGI] [12]
  FNR activator glnDp nd nd nd glnD
nd
 nd nd [BPP], [GEA], [IGI] [12]
  FNR repressor glnDp nd nd nd glnD
nd
 nd nd [BPP], [GEA], [IGI] [12]
  FNR activator glnKp Sigma54 nd nd glnK, amtB
nd
 nd nd [BPP], [GEA], [IGI] [12]
  FNR repressor glnKp Sigma54 nd nd glnK, amtB
nd
 nd nd [BPP], [GEA], [IGI] [12]
  FNR activator glpABCp Sigma70 -40.5 -104.5 glpA, glpB, glpC
gttcaaaatgACGCATGAAATCACGtttcactttc
 2352536 2352549 [AIBSCS], [GEA] [38], [39]
  FNR activator glpABCp Sigma70 -0.5 -64.5 glpA, glpB, glpC
atgagcgaatATGCGCGAAATCAAAcaattcatgt
 2352576 2352589 [APIORCISFBSCS], [GEA] [38], [39]
  FNR activator glpTQp Sigma70 -131.5 -208.5 glpT, glpQ
acatgaattgTTTGATTTCGCGCATattcgctcat
 2352576 2352589 [APIORCISFBSCS], [GEA] [40]
  FNR activator glpTQp Sigma70 -91.5 -168.5 glpT, glpQ
gaaagtgaaaCGTGATTTCATGCGTcattttgaac
 2352536 2352549 [AIBSCS], [GEA] [40]
  FNR repressor gltBp Sigma70 -26.5 -242.5 gltB, gltD, gltF
agcttgccatTTGACCTGTATCAGCtttcccgata
 3354476 3354489 [AIBSCS], [GEA] [10], [12]
  FNR repressor gltBp2 Sigma38 -26.5 -242.5 gltB, gltD, gltF
agcttgccatTTGACCTGTATCAGCtttcccgata
 3354476 3354489 [AIBSCS], [GEA] [10], [12]
  FNR repressor gndp Sigma70 nd nd gnd
nd
 nd nd [BPP], [GEA], [IGI] [12]
  FNR repressor grcAp1 Sigma70 -93.5 -167.5 grcA
acccgcataaGTTGATGTAAAACAAtaaaatccat
 2716610 2716623 [BPP], [GEA], [SM] [12], [41], [42], [43]
  FNR activator grcAp1 Sigma70 -40.5 -114.5 grcA
tgtggtttttATTGATTTAAATCAAagattcaagg
 2716557 2716570 [BPP], [GEA], [SM] [6], [41], [42], [43]
  FNR repressor grcAp1 Sigma70 -40.5 -114.5 grcA
tgtggtttttATTGATTTAAATCAAagattcaagg
 2716557 2716570 [BPP], [GEA], [SM] [6], [41], [42], [43]
  FNR activator hcpp nd -72.5 -103.5 hcp, hcr, poxB
tgccgccaaaATTGCGCTAAATCAAtctcccttaa
 913911 913924 [APIORCISFBSCS], [BPP], [GEA], [SM] [44], [45]
  FNR repressor hemAp1 Sigma70 -24.5 -62.5 hemA, prfA, prmC
ctctcttttaTTGATCTTACGCATCctgtatgatg
 1263645 1263658 [BPP], [GEA] [46], [47]
  FNR activator hlyEp nd -61.5 -133.5 hlyE
ttaaacattgTTTGATATTTATCATattaatagaa
 1230521 1230534 [BPP], [GEA] [48], [49]
  FNR repressor hmpp Sigma38 5.5 -33.5 hmp
taagatgcatTTGAGATACATCAATtaagatgcaa
 2685795 2685808 [APIORCISFBSCS], [BPP], [GEA], [SM] [50], [51], [52]
  FNR repressor hyfAp Sigma54 -105.5 -135.5 hyfA, hyfB, hyfC, hyfD, hyfE, hyfF, hyfG, hyfH, hyfI, hyfJ, hyfR, focB
aatccattttTTGCTGAACGTTAATgaccatcatt
 2601059 2601072 [APIORCISFBSCS], [GEA] [53]
  FNR activator hypBp nd -149.5 -311.5 hypB, hypC, hypD, hypE, fhlA
ggcactggaaTTGATCGAACAGCAGgccgcaaaac
 2850683 2850696 [BPP], [GEA] [54]
  FNR activator hypBp nd -43.5 -205.5 hypB, hypC, hypD, hypE, fhlA
gccttttgttTTGATCTGGTTTGCCgcggcagcgt
 2850789 2850802 [BCE], [BPP], [GEA] [54]
  FNR activator idlPp Sigma38 nd nd idlP, iraD
nd
 nd nd [BPP], [GEA], [IGI] [10]
  FNR activator iraDp2 Sigma70 nd nd idlP, iraD
nd
 nd nd [BPP], [GEA], [IGI] [10]
  FNR activator iraMp nd -70.5 -157.5 iraM
aaaatctcatTTTGTTTAACATCCAttgagattcc
 1212154 1212167 [AIBSCS] [55]
  FNR activator katGp Sigma70 -112.5 -135.5 katG
atcaaaaaagCTTAATTAAGATCAAtttgatctac
 4133693 4133706 [AIBSCS], [GEA] [10]
  FNR activator katGp Sigma70 -96.5 -119.5 katG
taagatcaatTTGATCTACATCTCTttaaccaaca
 4133709 4133722 [EME], [AIBSCS], [AIBSPD], [CCE], [GEA] [10], [56]
  FNR activator lpdAp Sigma70 nd nd lpd
nd
 nd nd [BPP], [GEA], [IGI] [8], [12]
  FNR repressor lpdAp Sigma70 nd nd lpd
nd
 nd nd [BPP], [GEA], [IGI] [8], [12]
  FNR activator malPp Sigma70 -127.5 -164.5 malP, malQ
attgcattgaTTTGATGCTAATCCTgtggtttgca
 3552631 3552644 [AIBSCS], [GEA] [10]
  FNR activator moaAp1 nd -39.5 -256.5 moaA, moaB, moaC, moaD, moaE
tgcctccctgATGATGTATATCAAAgtaaaaccgc
 816781 816794 [APIORCISFBSCS], [GEA] [57], [58]
  FNR repressor moeAp Sigma70 34.5 4.5 moeA, moeB
gcaggagtgtTTTCATGGAATTTACcaccggattg
 866354 866367 [BPP], [GEA] [59]
  FNR repressor nacp Sigma54 nd nd nac
nd
 nd nd [BPP], [GEA], [IGI] [12]
  FNR activator napFp1 Sigma70 -64.5 -141.5 napF, napD, napA, napG, napH, napB, napC, ccmA, ccmB, ccmC, ccmD, ccmE, ccmF, ccmG, ccmH
ccgccactctTTTGATCCTGCTACAggttttaccc
 2303632 2303645 [APIORCISFBSCS], [GEA], [SM] [60], [61]
  FNR activator narGp Sigma70 -41.5 -98.5 narG, narH, narJ, narI
cccatcactcTTGATCGTTATCAATtcccacgctg
 1279759 1279772 [APIORCISFBSCS], [BPP], [GEA], [SM] [26], [27]
  FNR activator narKp1 Sigma70 -79.5 -104.5 narK
actatgggtaATGATAAATATCAATgatagataaa
 1277846 1277859 [BCE], [GEA], [SM] [62]
  FNR activator narKp1 Sigma70 -41.5 -66.5 narK
atcttatcgtTTGATTTACATCAAAttgcctttag
 1277884 1277897 [EME], [AIBSPD], [BCE], [BPP], [CCE], [SM] [27], [56]
  FNR repressor narXp Sigma70 -106.5 -265.5 narX, narL
caatttgatgTAAATCAAACGATAAgataacttta
 1277877 1277890 [AIBSPD], [APIORCISFBSCS], [BCE], [CCE] [4], [63]
  FNR repressor narXp Sigma70 -75.0 -234.0 narX, narL
ttatctatcaTTGATATTTATCATTacccatagtg
 1277845 1277858 [APIORCISFBSCS], [BPP] [4]
  FNR repressor narXp Sigma70 107.5 -52.5 narX, narL
gccattccagAATGTATCGTCACATtcattaaggt
 1277664 1277677 [APIORCISFBSCS], [BCE] [4]
  FNR repressor ndhp Sigma70 -94.5 -187.5 ndh
actctgttttTTGATCTCACCCGGTaaagtcgcct
 1165891 1165904 [BCE], [GEA], [SM] [8], [12], [64]
  FNR repressor ndhp Sigma70 -50.5 -143.5 ndh
gcaacaaaacTTGATTAACATCAATtttggtatga
 1165935 1165948 [BCE], [GEA], [SM] [8], [12], [64]
  FNR activator nikAp1 nd -40.5 -79.5 nikA, nikB, nikC, nikD, nikE, nikR
tgcccatctaTTGATCCAGAACAGGtaatcagtat
 3613581 3613595 [APIORCISFBSCS], [GEA], [SM] [65], [66]
  FNR activator nirBp Sigma70 -41.5 -65.5 nirB, nirD, nirC, cysG
aaaggtgaatTTGATTTACATCAATaagcggggtt
 3493939 3493952 [APIORCISFBSCS], [BPP], [GEA], [SM] [1], [34], [67], [68], [69]
  FNR repressor norVp Sigma54 -140.5 -177.5 norV, norW
aaactcatctTTGCCTCACTGTCAAtttgactata
 2832292 2832305 [APIORCISFBSCS], [GEA] [70]
  FNR activator nrdDp Sigma70 -64.5 -242.5 nrdD, nrdG
tgctttttacTTTGAGCTACATCAAaaaaagctca
 4462896 4462909 [APIORCISFBSCS], [BPP], [GEA], [SM] [71], [72]
  FNR activator nrdDp Sigma70 -33.5 -211.5 nrdD, nrdG
ctcaaacatcCTTGATGCAAAGCACtatatataga
 4462865 4462878 [APIORCISFBSCS], [BPP], [GEA], [SM] [71], [72]
  FNR activator nrfAp Sigma70 -41.5 -134.5 nrfA, nrfB, nrfC, nrfD, nrfE, nrfF, nrfG
gcacttacaaTTGATTAAAGACAACattcacagtg
 4287623 4287636 [BCE], [BPP], [GEA] [73], [74]
  FNR repressor nuoAp2 Sigma70 -40.5 -130.5 nuoA, nuoB, nuoC, nuoE, nuoF, nuoG, nuoH, nuoI, nuoJ, nuoK, nuoL, nuoM, nuoN
agaaaggagtAAAAAACCACATCAAttagctgtat
 2405196 2405209 [BCE], [GEA], [SM] [8], [12]
  FNR repressor ompWp nd -126.5 -155.5 ompW
tatttaaaaaTTGATTTAAATCACAttaaccagga
 1313858 1313871 [AIBSCS], [BPP], [GEA] [75]
  FNR activator ompWp nd -81.5 -110.5 ompW
aacttctaaaTTAATCCAGATCAATaaagggtgaa
 1313903 1313916 [AIBSCS], [APIORCISFBSCS], [BPP], [GEA] [75]
  FNR repressor ompXp2 nd nd nd ompX
nd
 nd nd [BPP], [GEA], [IGI] [10]
  FNR activator pdhRp Sigma70 -50.5 -108.5 pdhR, aceE, aceF, lpd
gcacagtttcATGATTTCAATCAAAacctgtatgg
 121977 121990 [AIBSCS], [BCE], [GEA] [5], [8], [10]
  FNR repressor pdhRp Sigma70 -50.5 -108.5 pdhR, aceE, aceF, lpd
gcacagtttcATGATTTCAATCAAAacctgtatgg
 121977 121990 [AIBSCS], [BCE], [GEA] [5], [8], [10]
  FNR activator pdhRp2 Sigma38 -50.5 -108.5 pdhR, aceE, aceF, lpd
gcacagtttcATGATTTCAATCAAAacctgtatgg
 121977 121990 [AIBSCS], [BCE], [GEA] [5], [8], [10]
  FNR repressor pdhRp2 Sigma38 -50.5 -108.5 pdhR, aceE, aceF, lpd
gcacagtttcATGATTTCAATCAAAacctgtatgg
 121977 121990 [AIBSCS], [BCE], [GEA] [5], [8], [10]
  FNR activator pepTp nd nd nd pepT
nd
 nd nd [BPP], [GEA], [IGI] [10]
  FNR activator pitAp nd nd nd pitA
nd
 nd nd [BPP], [GEA], [IGI] [10]
  FNR activator pstSp Sigma70 nd nd pstS, pstC, pstA, pstB, phoU
nd
 nd nd [BPP], [GEA], [IGI] [8]
  FNR activator pstSp2 Sigma38 nd nd pstS, pstC, pstA, pstB, phoU
nd
 nd nd [BPP], [GEA], [IGI] [8]
  FNR repressor purMp Sigma70 -192.5 -236.5 purM, purN
attcttttcgTTGACTTTAGTCAAAatgataacgg
 2620954 2620967 [AIBSCS], [APIORCISFBSCS], [GEA], [SM] [8], [76]
  FNR repressor puuAp Sigma38 29.0 -32.0 puuA, ymjE, puuP
tattttacgcTTTGATAACGAGCGGaaaacaaacc
 1360933 1360946 [AIBSCS], [GEA] [55]
  FNR activator ravAp Sigma38 -201.5 -236.5 ravA, viaA
gcgggcaatgATTGCTTATTATCAGtgctcataga
 3931323 3931336 [APIORCISFBSCS], [BPP], [GEA], [SM] [77]
  FNR activator ravAp Sigma38 -71.5 -106.5 ravA, viaA
atgcggccacATTAACCTGGCTCAAagaaaaatac
 3931193 3931206 [APIORCISFBSCS], [BPP], [GEA], [SM] [77]
  FNR repressor rplMp nd nd nd rplM, rpsI
nd
 nd nd [BPP], [GEA], [IGI] [8]
  FNR repressor rplTp nd nd nd rplT, pheM
nd
 nd nd [BPP], [GEA], [IGI] [8]
  FNR activator rpsJp Sigma70 nd nd rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ
nd
 nd nd [BPP], [GEA], [IGI] [8]
  FNR repressor rpsPp Sigma70 nd nd rpsP, rimM, trmD, rplS
nd
 nd nd [BPP], [GEA], [IGI] [8]
  FNR repressor sdhCp Sigma70 nd nd sdhC, sdhD, sdhA, sdhB, sucA, sucB, sucC, sucD, sdhX
nd
 nd nd [BPP], [GEA], [IGI] [12], [78]
  FNR repressor sodAp Sigma70 -37.5 -88.5 sodA
aagtacggcaTTGATAATCATTTTCaatatcattt
 4100715 4100728 [BCE], [GEA] [12], [79], [80]
  FNR repressor soxRp Sigma70 nd nd soxR
nd
 nd nd [BPP], [GEA], [IGI] [12]
  FNR repressor soxSp Sigma70 nd nd soxS
nd
 nd nd [BPP], [GEA], [IGI] [12]
  FNR activator ssuEp Sigma70 nd nd ssuE, ssuA, ssuD, ssuC, ssuB
nd
 nd nd [BPP], [GEA], [IGI] [8]
  FNR repressor sucAp Sigma38 nd nd sucA, sucB, sucC, sucD
nd
 nd nd [BPP], [GEA], [IGI] [81]
  FNR activator tarp Sigma28 nd nd tar, tap, cheR, cheB, cheY, cheZ
nd
 nd nd [BPP], [GEA], [IGI] [10]
  FNR activator tdcAp nd -148.5 -176.5 tdcA, tdcB, tdcC, tdcD, tdcE, tdcF, tdcG
cgtcatttttTTTGACAAAAATCAGggtttatgct
 3267235 3267248 [AIBSCS], [GEA] [10]
  FNR activator tdcAp nd -105.5 -133.5 tdcA, tdcB, tdcC, tdcD, tdcE, tdcF, tdcG
tactttaactTGTTGATATTTAAAGgtatttaatt
 3267192 3267205 [AIBSCS], [GEA] [10]
  FNR repressor tpxp Sigma70 -18.5 -51.5 tpx
ttgctgtgttATTGACAGTTAGCATaaactaggtg
 1388856 1388869 [APIORCISFBSCS], [GEA] [82]
  FNR repressor ubiCp Sigma70 -0.5 -63.5 ubiC, ubiA
atcacttaatTTGCTTTACATCTCCcgtaaacact
 4252436 4252449 [APIORCISFBSCS], [GEA] [83]
  FNR activator uppp Sigma70 -61.5 -98.5 upp, uraA
ttatctcaaaCCGTTATCATTTTGActaaagtcaa
 2620964 2620977 [AIBSCS], [GEA] [10]
  FNR activator uxaCp Sigma70 nd nd uxaC, uxaA
nd
 nd nd [BPP], [GEA], [IGI] [10]
  FNR activator xdhAp nd nd nd xdhA, xdhB, xdhC
nd
 nd nd [BPP], [GEA], [IGI] [8]
  FNR activator ybdNp Sigma70 -303.5 -420.5 ybdN
atcagcagggGTTGATGATATTCAAatggaaatag
 636983 636996 [AIBSCS] [55]
  FNR activator ybdNp Sigma70 -26.5 -143.5 ybdN
aatgagagttTTTGATATATAACTAcagacagcta
 636706 636719 [AIBSCS] [55]
  FNR repressor ychOp Sigma70 nd nd ychO
nd
 nd nd [BPP], [GEA], [IGI] [10]
  FNR activator ydeJp Sigma70 -404.5 -489.5 ydeJ
gtcctctcctTTGTGAGAAATCAAAttaccgcgta
 1624277 1624290 [AIBSCS] [55]
  FNR activator ydhYp Sigma38 -42.5 -207.5 ydhY, ydhV, ydhW, ydhX, ydhU, ydhT
tgtaattttaATTGATAACGATCAAtgttaagggc
 1754678 1754691 [APIORCISFBSCS], [BPP], [GEA], [SM] [84]
  FNR activator yecRp nd nd nd yecR
nd
 nd nd [BPP], [GEA], [IGI] [10]
  FNR repressor yeiLp Sigma38 -28.5 -93.5 yeiL
gggccgatgaTTGAATCTTAACAACagcgtacgta