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CRP DNA-binding transcriptional dual regulator

Synonyms: CRP-cAMP, CRP
Summary:
The transcriptional dual regulator CRP, cAMP receptor protein, also called CAP, catabolite gene activator protein, regulates the expression of over 180 genes [33, 277, 303] in E. coli. Many of these genes are involved in the catabolism of secondary carbon sources (for reviews, see [304, 305, 306, 307]. In addition, CRP is involved in many other processes, such as osmoregulation [308, 309], stringent response [310], biofilm formation [311], virulence [309], nitrogen assimilation [126, 137, 312], iron uptake [4], competence [313], multidrug resistance to antibiotics [110, 314], and expression of CyaR sRNA [61].
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Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
CRP Non-Functional   Apo [IPI] [1], [2]
CRP-cAMP Functional Allosteric Holo [IPI] [1], [2]
Evolutionary Family: CRP
Sensing class: Using internal synthesized signals
Connectivity class: Global Regulator
Gene name: crp
  Genome position: 3486120-3486752
  Length: 633 bp / 210 aa
Operon name: crp
TU(s) encoding the TF:
Transcription unit        Promoter
crp
crpp1
crp
crpp2
crp
crpp3


Regulon       
Regulated gene(s) aaeA, aaeB, aaeR, aaeX, aceA, aceB, aceE, aceF, aceK, acnA, acnB, acs, actP, aer, agaA, agaV, agaW, agp, aldA, aldB, ampD, ampE, ansB, araA, araB, araC, araD, araE, araF, araG, araH, araJ, arfB, argG, aroA, ascB, ascF, aspA, azuC, bglB, bglF, bglG, bhsA, caiA, caiB, caiC, caiD, caiE, caiF, caiT, cas1, cas2, casA, casB, casC, casD, casE, cdd, chbA, chbB, chbC, chbF, chbG, chbR, chiP,
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Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
membrane (97)
Transcription related (59)
activator (40)
Porters (Uni-, Sym- and Antiporters) (37)
operon (37)
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Regulated operon(s) aaeR, aaeXAB, aceBAK, acnA, acnB, acs-yjcH-actP, aer, agp, aldA, aldB, ampDE, ansB, araBAD, araC, araE-ygeA, araFGH, araJ, argG, ascFB, aspA-dcuA, azuC, bglGFB, bhsA, caiF, caiTABCDE, casABCDE12, cdd, chbBCARFG, chiP-ybfN, cirA, citCDEFXG, comR, cpdB, crp, csgDEFG, csiD-lhgO-gabDTP, csiE, cspD, cspE, csrC, cstA, cyaA, cyaR, cyoABCDE, cytR, dadAX, dctA, dcuB-fumB, dcuSR, deoCABD, dpiBA, dsdXA, dusB-fis, ebgAC, entCEBAH, epd-pgk-fbaA, exuT, fadD-sroD, fadH, fadL, feaB, feaR, fecABCDE, fepA-entD, fiu,
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First gene in the operon(s) aaeR, aaeX, aceB, acnA, acnB, acs, aer, agp, aldA, aldB, ampD, ansB, araB, araC, araE, araE, araF, araJ, argG, ascF, aspA, aspA, azuC, bglG, bglG, bglG, bhsA, caiF, caiT, casA, cdd, chbB, chiP, cirA, cirA, citC, comR, cpdB, crp, csgD, csiD, csiE, cspD, cspE, csrC, cstA, cyaA, cyaR, cyoA, cytR, dadA, dadA, dadA, dctA, dcuB, dcuR, deoC, dpiB, dsdA, dsdX, dusB, ebgA, entC, epd, epd,
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Simple and complex regulons AcrR,CRP,CpxR,Cra,Fis,MarA,MarR,Rob,SoxS
AcrR,CRP,FliZ,Fur,H-NS,HdfR,IHF,LrhA,MatA,OmpR,QseB,RcsB,YjjQ
AdiY,ArcA,CRP,FNR,Fis,GadW,GadX,H-NS,RcsB,TorR
AdiY,ArgR,CRP,FNR,Fur,GadE,HdfR,IHF,Lrp,Nac
AdiY,CRP,Fis,FliZ,GadE,GadW,GadX,RcsB
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Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)
[CRP,-](64)
[CRP,+-](14)
[CRP,+](188)


Transcription factor binding sites (TFBSs) arrangements       

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  CRP-cAMP repressor aaeRp nd -2.5 -26.5 aaeR
gttatctataTTATGTGATCTAAATCACTTTTaagtcagagt
3389483 3389504 [GEA], [HIBSCS] [3]
  CRP-cAMP activator aaeXp nd -63.5 -156.5 aaeX, aaeA, aaeB
actctgacttAAAAGTGATTTAGATCACATAAtatagataac
3389483 3389504 [GEA], [HIBSCS] [3]
  CRP-cAMP repressor aceBp Sigma70 -30.5 -106.5 aceB, aceA, aceK
ttaaaatggaAATTGTTTTTGATTTTGCATTTtaaatgagta
4215361 4215382 [AIBSCS], [GEA] [4]
  CRP-cAMP activator acnAp2 Sigma70 -40.5 -90.5 acnA
ctcttttatcAATTTGGGTTGTTATCAAATCGttacgcgatg
1335730 1335751 [GEA], [HIBSCS] [5]
  CRP-cAMP activator acnBp Sigma70 -37.5 -133.5 acnB
tatgttgcttTTTTGTAAACAGATTAACACCTcgtcaaaatc
131471 131492 [GEA], [HIBSCS] [5]
  CRP-cAMP activator acsp2 Sigma70 -122.5 -142.5 acs, yjcH, actP
ttaatcaactTTTGTTGCTGACCTTCAAAAATtaccctgccg
4287503 4287524 [AIBSCS], [BPP], [GEA], [SM] [6], [7], [8]
  CRP-cAMP activator acsp2 Sigma70 -69.5 -89.5 acs, yjcH, actP
aattctacttTTGCGTGATCTGTCGCCCAAATactaaacaaa
4287450 4287471 [AIBSCS], [BPP], [GEA], [SM] [6], [7], [8]
  CRP-cAMP activator aerp Sigma28 -49.5 -93.5 aer
ttaaatcgcaAATTGCGATCTAAATCAAATTAatcggttaaa
3219159 3219180 [AIBSCS], [BCE], [BPP], [GEA], [SM] [9], [10]
  CRP-cAMP activator agpp nd -232.5 -258.5 agp
tgctaaaaacCATTGTTATTAGTCTCACACTTttttattggt
1065316 1065337 [AIBSCS], [GEA] [11]
  CRP-cAMP activator aldAp Sigma70 -59.5 -101.5 aldA
ttacacttgtTTTTATGAAGCCCTTCACAGAAttgtcctttc
1488120 1488141 [BCE], [GEA] [12]
  CRP-cAMP activator aldBp Sigma38 -60.5 -84.5 aldB
cttgcccgtaAATTCGTGATAGCTGTCGTAAAgctgttaccg
3756585 3756606 [AIBSCS], [BPP] [13]
  CRP-cAMP repressor ampD nd 6.5 -24.5 ampD, ampE
gctactctgaACCGGGTATTAGCACCACATATaaggagatcc
118698 118719 [AIBSCS], [GEA], [HIBSCS] [3]
  CRP-cAMP activator ansBp2 Sigma70 -91.5 -114.5 ansB
taattcttcgTTTTGTTACCTGCCTCTAACTTtgtagatctc
3100832 3100853 [BCE], [SM] [14]
  CRP-cAMP activator araBp Sigma70 -93.5 -120.5 araB, araA, araD
tccacattgaTTATTTGCACGGCGTCACACTTtgctatgcca
70158 70179 [BPP], [GEA], [HIBSCS], [SM] [15], [16], [17], [18], [19], [20]
  CRP-cAMP activator araCp Sigma70 -72.5 -218.5 araC
tggcatagcaAAGTGTGACGCCGTGCAAATAAtcaatgtgga
70158 70179 [BPP], [GEA], [HIBSCS], [SM] [15], [16], [17], [18], [19], [20]
  CRP-cAMP activator araEp Sigma70 -94.5 -120.5 araE, ygeA
ttaatttgaaAATTGGAATATCCATCACATAAcgacatgtcg
2982292 2982313 [AIBSCS], [BPP] [21]
  CRP-cAMP activator araFp Sigma70 -42.5 -152.5 araF, araG, araH
tgtaattctgCGATGTGATATTGCTCTCCTATggagaattaa
1986270 1986291 [BPP], [GEA], [HIBSCS], [SM] [22], [23], [24]
  CRP-cAMP activator araJp Sigma70 -90.5 -138.5 araJ
cagcaaactgGAAAGTACGTTTGCAGTGAAATaactattcag
412609 412630 [BPP], [HIBSCS] [23], [25]
  CRP-cAMP repressor araJp Sigma70 44.5 -4.5 araJ
ccgttctggtGGTTGTGATGGTGGTATGAAAAaagtcatttt
412475 412496 [BPP], [HIBSCS] [23], [25]
  CRP-cAMP activator argGp Sigma70 -167.5 -242.5 argG
ctgcaggcatTATAGTGATCCACGCCACATTTtgtcaacgtt
3318384 3318405 [BPP], [GEA], [SM] [26]
  CRP-cAMP activator ascFp Sigma70 -71.5 -166.5 ascF, ascB
ggaaaaatatTCAGGTGACCGGTTTCACAAATataaaaaatg
2839347 2839368 [BPP], [ICWHO] [27]
  CRP-cAMP activator aspAp Sigma70 -90.5 -195.5 aspA, dcuA
gtaatcccaaAGCGGTGATCTATTTCACAAATtaataattaa
4368512 4368533 [GEA], [HIBSCS] [28], [29]
  CRP-cAMP repressor azuCp Sigma70 -48.5 -90.5 azuC
aaaggggtatTTATGTGATTTGTATCACATAAagattgattt
1988039 1988060 [GEA], [HIBSCS] [30]
  CRP-cAMP repressor azuCp Sigma70 -18.5 -60.5 azuC
aaagattgatTTTTGTGATGGTTGTCATATTAtaagcgcaaa
1988009 1988030 [GEA], [HIBSCS] [30]
  CRP-cAMP activator bglGp nd -61.5 -191.5 bglG, bglF, bglB
caaagttaatAACTGCGAGCATGGTCATATTTttatcaatag
3906748 3906769 [AIBSCS], [BPP], [GEA], [SM] [31], [32], [33]
  CRP-cAMP activator bglGp2 nd -41.5 -191.5 bglG
caaagttaatAACTGCGAGCATGGTCATATTTttatcaatag
3906748 3906769 [AIBSCS], [BPP], [GEA], [SM] [31], [32], [33]
  CRP-cAMP repressor bhsAp Sigma24 -36.5 -76.5 bhsA
aaaatatcttGTATGTGATCCAGATCACATCTatcatttagt
1168986 1169007 [BPP], [GEA], [HIBSCS] [3], [34]
  CRP-cAMP activator caiFp Sigma70 -41.5 -123.5 caiF
ttgatgacatAAGCAGGATTTAGCTCACACTTatcgacggtg
34166 34187 [BCE], [GEA] [35]
  CRP-cAMP activator caiTp Sigma70 -41.5 -147.5 caiT, caiA, caiB, caiC, caiD, caiE
cccgaaacaaAAATGTGATACCAATCACAGAAtacagcttat
42068 42089 [BCE], [GEA], [HIBSCS] [36], [37], [38]
  CRP-cAMP repressor casp Sigma70 -89.5 -270.5 casA, casB, casC, casD, casE, cas1, cas2
tatgaatattTTATGTAATAAAATTCATGGtaattattat
2884399 2884418 [BPP], [GEA], [HIBSCS] [39]
  CRP-cAMP repressor cddp Sigma70 -94.5 -119.5 cdd
taatgggctaAAATTTGCGATGCGTCGCGCATttttgatgta
2231714 2231735 [BPP], [GEA], [SM] [40], [41]
  CRP-cAMP activator cddp Sigma70 -92.5 -117.5 cdd
atgggctaaaATTTGCGATGCGTCGCGCATTTttgatgtatg
2231716 2231737 [BPP], [GEA], [SM] [40], [41]
  CRP-cAMP dual cddp Sigma70 -42.5 -67.5 cdd
gttgcataatTAATGAGATTCAGATCACATATaaagccacaa
2231766 2231787 [BPP], [GEA], [SM] [40], [41]
  CRP-cAMP activator chbBp nd -83.5 -190.5 chbB, chbC, chbA, chbR, chbF, chbG
tatttgcccgAAATGTGAAGAGGGTCATAACCacaggtcaag
1821799 1821820 [AIBSCS], [BPP], [GEA], [HIBSCS] [33], [42]
  CRP-cAMP activator chiPp nd -70.5 -168.5 chiP, ybfN
catcaaaataTGTGCGGTTGCTCATGttcttacatt
708158 708173 [HIBSCS] [43]
  CRP-cAMP activator cirAp1 Sigma70 nd nd cirA nd nd [GEA], [HIBSCS] [44]
  CRP-cAMP activator cirAp2 Sigma70 nd nd cirA nd nd nd [44]
  CRP-cAMP repressor citCp2 nd 11.5 -172.5 citC, citD, citE, citF, citX, citG
accactaactCTATGTGAAATAAATCAAAATTtcacgccgaa
652018 652039 [AIBSCS] [45]
  CRP-cAMP repressor comRp nd -152.5 -164.5 comR
actaaatgatAGATGTGATCTGGATCACATACaagatatttt
1168986 1169007 [BPP], [GEA], [HIBSCS] [3], [34]
  CRP-cAMP activator cpdBp Sigma70 -44.0 -107.5 cpdB
tgaatgcgccAACTGTGATAGTGTCATCATTTtcaaagcgta
4436662 4436683 [BCE], [SM] [46]
  CRP-cAMP activator crpp1 Sigma70 -59.5 -226.5 crp
cgcgcaacggAAGGCGACCTGGGTCATGCTGAagcgagacac
3485883 3485904 [BPP], [HIBSCS], [SM] [47], [48], [49]
  CRP-cAMP repressor crpp1 Sigma70 41.5 -126.5 crp
atgtactgcaTGTATGCAAAGGACGTCACATTaccgtgcagt
3485983 3486004 [AIBSCS], [BPP], [GEA], [HIBSCS], [SM] [33], [47], [48], [49]
  CRP-cAMP activator csgDp1 Sigma38 -170.5 -318.5 csgD, csgE, csgF, csgG
tttatatgcaTTATTAGTAAGTTATCACCATTtgtatgattt
1103504 1103525 [AIBSCS], [GEA] [33]
  CRP-cAMP activator csgDp1 Sigma38 -42.5 -190.5 csgD, csgE, csgF, csgG
acgagttacaTTTAGTTACATGTTTAACACTTgatttaagat
1103376 1103397 [AIBSCS], [GEA] [33]
  CRP-cAMP activator csiDp Sigma38 -68.5 -126.5 csiD, lhgO, gabD, gabT, gabP
atgttactaaTTTGTTGCTTTTGATCACAATAagaaaacaat
2788848 2788869 [AIBSCS], [BPP], [GEA] [50], [51]
  CRP-cAMP activator csiEp Sigma70 -42.5 -76.5 csiE
acgcttgccaACATTTCTGATGATTAGCATTCccttcgccat
2665348 2665369 [GEA] [52]
  CRP-cAMP activator cspDp Sigma70 -112.5 -198.5 cspD
tatcgttggcATCAGCGACATCTGTCACATTCctgtcaatag
922778 922799 [BPP], [GEA], [HIBSCS], [SM] [53]
  CRP-cAMP activator cspDp Sigma70 -83.5 -169.5 cspD
ttcctgtcaaTAGCGTTAACTGCTTCAAATTTttgattcata
922749 922770 [AIBSCS], [BPP], [GEA], [SM] [53]
  CRP-cAMP activator cspEp2 Sigma70 -61.5 -103.5 cspE
acatcaaaaaTAACGCGACTTTTATCACTTTTtagtaaagtt
657178 657199 [BPP], [GEA], [HIBSCS], [SM] [54]
  CRP-cAMP repressor csrCp nd -191.5 -191.5 csrC
gatttttcggCGTGAGCGTTGTAAGTaaaagccata
4050837 4050852 [BPP], [GEA], [HIBSCS] [55]
  CRP-cAMP repressor csrCp nd -160.5 -160.5 csrC
ccatacgcttTGTGAGACATTGCCGAtagtctttat
4050868 4050883 [BPP], [GEA], [HIBSCS] [55]
  CRP-cAMP repressor csrCp nd -113.5 -113.5 csrC
gagaaaattcTGCGATGCATGTCAAAtaagctatat
4050915 4050930 [BPP], [GEA], [HIBSCS] [55]
  CRP-cAMP activator cstAp1 nd -89.5 -128.5 cstA
actcggttaaCGGAGTGATCGAGTTAACATTGttaagttaaa
629755 629776 [GEA], [SM] [56], [57], [58]
  CRP-cAMP repressor cyaAp Sigma70 -2.0 -156.5 cyaA
cagcaaggtgTTAAATTGATCACGTTTTAGACcattttttcg
3990986 3991007 [BPP], [GEA], [HIBSCS] [59], [60]
  CRP-cAMP activator cyaRp Sigma24 -42.5 -42.5 cyaR
ggatggaaaaTTCTTAGAAACCGATCACATACagctgcattt
2167061 2167082 [AIBSCS], [BPP], [GEA], [SM] [61], [62]
  CRP-cAMP activator cyoAp Sigma70 -191.5 -234.5 cyoA, cyoB, cyoC, cyoD, cyoE
tatttgttaaATAATTGTTTTATTTCACATTGgttataccaa
451834 451855 [AIBSCS], [GEA] [33]
  CRP-cAMP activator cyoAp Sigma70 -37.5 -80.5 cyoA, cyoB, cyoC, cyoD, cyoE
caagtaacagGAATTTAATCATGTTTACAGTAatgtaacctt
451680 451701 [AIBSCS], [GEA] [33]
  CRP-cAMP dual cytRp Sigma70 -64.5 -117.5 cytR
gcggatcgaaAAATTCAATATTCATCACACTTttcatgaaaa
4124563 4124584 [BPP], [GEA], [HIBSCS] [63], [64]
  CRP-cAMP activator dadAp1 Sigma70 -43.5 -105.5 dadA, dadX
agagtcagggAGATGTGAGCCAGCTCACCATAaaaaagccgc
1237455 1237476 [BPP], [GEA], [HIBSCS] [65], [66], [67], [68]
  CRP-cAMP dual dadAp1 Sigma70 20.5 -42.5 dadA, dadX
tgagttatcaAGATGTGATTAGATTATTATTCttttactgta
1237518 1237539 [BPP], [GEA], [HIBSCS] [65], [66], [67], [68]
  CRP-cAMP activator dadAp2 Sigma70 -59.5 -105.5 dadA, dadX
agagtcagggAGATGTGAGCCAGCTCACCATAaaaaagccgc
1237455 1237476 [BPP], [GEA], [HIBSCS] [65], [66], [67], [68]
  CRP-cAMP activator dadAp2 Sigma70 7.0 -40.5 dadA, dadX
agttatcaagATGTGATTAGATTATTATTCTTttactgtatc
1237520 1237541 [BPP], [GEA], [HIBSCS] [65], [68]
  CRP-cAMP activator dadAp3 Sigma70 -72.5 -105.5 dadA, dadX
agagtcagggAGATGTGAGCCAGCTCACCATAaaaaagccgc
1237455 1237476 [BPP], [GEA], [HIBSCS] [65], [66], [67], [68]
  CRP-cAMP activator dadAp3 Sigma70 -9.5 -42.5 dadA, dadX
tgagttatcaAGATGTGATTAGATTATTATTCttttactgta
1237518 1237539 [BPP], [GEA], [HIBSCS] [65], [66], [67], [68]
  CRP-cAMP activator dctAp Sigma70 -81.5 -132.5 dctA
aagtgctggtTTGTGCGAGCCAGCTCAAACTTtttaaccttt
3683569 3683590 [BPP], [GEA], [HIBSCS] [69]
  CRP-cAMP activator dcuBp Sigma70 -106.5 -126.5 dcuB, fumB
agccaatattCACTGTGAGGTATTTGCTAAAGccggtaacga
4348860 4348881 [GEA], [HIBSCS] [28], [70]
  CRP-cAMP activator dcuRp Sigma70 -57.5 -588.5 dcuR
tgctgacgcaCTTCGTGAACGATCCCACGAATttatgaataa
4350612 4350633 [BPP], [HIBSCS] [71]
  CRP-cAMP dual deoCp2 Sigma70 -93.5 -138.5 deoC, deoA, deoB, deoD
tgaaagtgaaTTATTTGAACCAGATCGCATTAcagtgatgca
4617174 4617195 [AIBSCS], [BPP], [GEA], [HIBSCS], [SM] [33], [41], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86]
  CRP-cAMP activator deoCp2 Sigma70 -40.5 -85.5 deoC, deoA, deoB, deoD
agatttccttAATTGTGATGTGTATCGAAGTGtgttgcggag
4617227 4617248 [BPP], [GEA], [HIBSCS], [SM] [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [87]
  CRP-cAMP repressor dpiBp nd 45.5 -206.5 dpiB, dpiA
ttcggcgtgaAATTTTGATTTATTTCACATAGagttagtggt
652018 652039 [AIBSCS] [45]
  CRP-cAMP activator dsdAp Sigma70 nd nd dsdA nd nd [HIBSCS] [88]
  CRP-cAMP activator dsdXp Sigma70 -117.5 -143.5 dsdX, dsdA
tgagatgagcTAAAGTGAACCATATCTCAATTcaccttcatt
2477693 2477714 [BCE] [89]
  CRP-cAMP activator dsdXp Sigma70 -87.5 -113.5 dsdX, dsdA
ttcaccttcaTTTTTAGATGTAAATCACTCCAttgatgcaat
2477723 2477744 [BCE] [89]
  CRP-cAMP activator dusBp Sigma70 -252.5 -286.5 dusB, fis
acgcggggcgAAGTGCGAGCAAGCTCACAAAAggcacgtaaa
3409983 3410004 [AIBSCS], [GEA] [33]
  CRP-cAMP activator dusBp Sigma70 -167.5 -201.5 dusB, fis
cataaagaaaAATTGAGAACTTACTCAAATTTctttgagtgt
3410068 3410089 [AIBSCS], [GEA] [33]
  CRP-cAMP dual dusBp Sigma70 -63.0 -97.5 dusB, fis
tttaaatgcaATTCTTTGATCCATCTCAGAGGattggtcaaa
3410172 3410193 [BPP], [GEA] [90]
  CRP-cAMP activator ebgAp Sigma70 nd nd ebgA, ebgC nd nd [HIBSCS] [91]
  CRP-cAMP activator entCp Sigma70 -267.5 -321.5 entC, entE, entB, entA, entH
gcgtaatgacAAATTCGACAAAGCGCACAATCcgtcccctcg
624553 624574 [AIBSCS], [GEA] [4]
  CRP-cAMP activator entCp Sigma70 -29.5 -83.5 entC, entE, entB, entA, entH
cgttacctcaAGAGTTGACATAGTGCGCGTTTgcttttaggt
624791 624812 [AIBSCS], [GEA] [4]
  CRP-cAMP activator epdp Sigma70 -70.5 -202.5 epd, pgk, fbaA
aaggggataaAAGTGTGATGTGAGTCAGATAAatgtcttctt
3073883 3073904 [BCE], [GEA], [HIBSCS], [SM] [92]
  CRP-cAMP activator exuTp2 nd -161.5 -383.5 exuT
ccgaagatatTTTCGTGAGTTAGATCAATAAAcgtagttaaa
3244830 3244851 [AIBSCS] [93]
  CRP-cAMP activator exuTp2 nd -39.5 -261.5 exuT
atattcccacATTTGTGATGGCTCTCACCTTTtaaagttgta
3244952 3244973 [HIBSCS] [93], [94]
  CRP-cAMP activator fadDp Sigma70 -59.5 -120.5 fadD, sroD
gataaaaataAATAGTGACGCGCTTCGCAACCttttcgttgg
1889856 1889877 [AIBSCS], [BPP], [GEA] [33], [95]
  CRP-cAMP activator fadHp nd -61.5 -102.5 fadH
ccgggcgtatTCTTTTTGAATCCCATCACAAAccccgcactc
3231552 3231573 [GEA], [HIBSCS] [96]
  CRP-cAMP activator fadLp Sigma38 -157.5 -258.5 fadL
gcaaaatcggATAAGTGACCGAAATCACACTTaaaaatgatc
2461037 2461058 [BPP], [GEA] [95]
  CRP-cAMP activator feaBp1 Sigma70 -71.5 -98.5 feaB
tattgtcacgATTTGCGGAGCTTGTCACAGCTgacaaagcga
1447410 1447431 [GEA], [HIBSCS] [97], [98]
  CRP-cAMP activator feaRp2 Sigma70 -111.5 -137.5 feaR
tcgctttgtcAGCTGTGACAAGCTCCGCAAATcgtgacaata
1447410 1447431 [HIBSCS] [97], [98]
  CRP-cAMP activator fecAp Sigma19 nd nd fecA, fecB, fecC, fecD, fecE nd nd [GEA] [4]
  CRP-cAMP activator fepAp Sigma70 -42.5 -215.5 fepA, entD
accccatgttTACTGTGCAATTTTTCATTGATtgcagaaata
612699 612720 [AIBSCS], [GEA] [4]
  CRP-cAMP activator fiup Sigma70 -158.5 -275.5 fiu
agatgttcggTACTGCAACCATCTACAAATAAccccaccaac
841796 841817 [AIBSCS], [GEA] [4]
  CRP-cAMP activator fixAp Sigma70 -126.5 -204.5 fixA, fixB, fixC, fixX
gactttcaatATTGGTGATCCATAAAACAATAttgaaaattt
42188 42209 [GEA], [HIBSCS] [35], [36], [37]
  CRP-cAMP activator fixAp Sigma70 -69.5 -147.5 fixA, fixB, fixC, fixX
tgttttcaatATTGGTGAGGAACTTAACAATAttgaaagttg
42245 42266 [GEA], [HIBSCS] [35], [36], [37]
  CRP-cAMP activator flhDp Sigma70 -71.5 -269.5 flhD, flhC
attgagtgttTTGTGTGATCTGCATCACGCATtattgaaaat
1978456 1978477 [BPP], [GEA], [HIBSCS] [99], [100], [101]
  CRP-cAMP activator focAp1 Sigma70 -40.5 -67.5 focA, pflB
aagccaggcgAGATATGATCTATATCAATTTCtcatctataa
954523 954544 [AIBSCS], [BCE], [GEA], [HIBSCS], [SM] [33], [102]
  CRP-cAMP activator fucAp Sigma70 nd nd fucA, fucO nd nd [AIBSCS], [GEA], [IMP] [33], [103]
  CRP-cAMP activator fucPp Sigma70 -80.5 -196.5 fucP, fucI, fucK, fucU, fucR
tttcgattatTAAAGTGATGGTAGTCACATAAagtcaccttc
2934028 2934049 [AIBSCS], [BPP], [GEA] [33], [104]
  CRP-cAMP activator fucPp Sigma70 -40.5 -156.5 fucP, fucI, fucK, fucU, fucR
tctagctaatAAGTGTGACCGCCGTCATATTAcagagcgttt
2934068 2934089 [BPP], [GEA], [SM] [103], [104]
  CRP-cAMP activator fumAp Sigma70 -402.5 -465.5 fumA, fumC
aatggagagtGGCTGTGCTGCGCATAATACTTtgaacaggaa
1688832 1688853 [AIBSCS], [GEA] [4]
  CRP-cAMP activator fumAp Sigma70 -117.5 -180.5 fumA, fumC
catgatcaatCCCTGTTTTAATGTGGAAATTAatcccactat
1688547 1688568 [HIBSCS] [105]
  CRP-cAMP activator fumAp Sigma70 -109.5 -172.5 fumA, fumC
atccctgtttTAATGTGGAAATTAATCCCACTattaaagcaa
1688539 1688560 [HIBSCS] [105]
  CRP-cAMP activator fumAp Sigma70 -47.0 -110.0 fumA, fumC
tggagccgcaAAAAGTCGTACTAGTCTCAGTTTttgttaaaaa
1688476 1688498 [HIBSCS] [106]
  CRP-cAMP activator fumAp Sigma70 63.5 -0.5 fumA, fumC
caggcagtaaGTGAGAGAACAATGTCAAACAAaccctttcat
1688367 1688388 [BPP], [GEA], [HIBSCS], [SM] [107]
  CRP-cAMP unknown fumCp Sigma38 -484.5 -605.5 fumC
gattatcgtcGGTCGTGATATTGCTCACGCCAaactgaaaga
1687183 1687204 [BPP], [GEA], [HIBSCS], [SM] [107]
  CRP-cAMP activator fumCp Sigma38 -53.5 -174.5 fumC
atgacttcttCCAGCAGATACAACTCACACAAtgcacccgct
1686752 1686773 [BPP], [GEA], [HIBSCS], [SM] [107]
  CRP-cAMP activator furpa Sigma70 -77.5 -147.5 fur
ttgccgttgtAAATGTAAGCTGTGCCACGTTTttattaacaa
710783 710804 [HIBSCS], [SM] [108]
  CRP-cAMP activator furpb Sigma70 -70.5 -147.5 fur
ttgccgttgtAAATGTAAGCTGTGCCACGTTTttattaacaa
710783 710804 [HIBSCS], [SM] [108]
  CRP-cAMP repressor gadAp Sigma38 -62.5 -89.5 gadA, gadX
cgtttttctgCTTAGGATTTTGTTATTTAAATtaagcctgta
3667659 3667680 [GEA], [HIBSCS] [109]
  CRP-cAMP repressor gadBp Sigma38 -63.5 -90.5 gadB, gadC
cgataaataaCATTAGGATTTTGTTATTTAAAcacgagtcct
1572125 1572146 [GEA], [HIBSCS] [109]
  CRP-cAMP repressor gadEp Sigma38 -19.5 -40.5 gadE, gadF, mdtE, mdtF
caaggatgtaAATAATGAAAAGGATGACATATtcgaaacgat
3658315 3658336 [BPP], [HIBSCS] [110]
  CRP-cAMP activator galEp1 Sigma70 -41.5 -67.5 galE, galT, galK, galM
acgattccacTAATTTATTCCATGTCACACTTttcgcatctt
792112 792133 [GEA], [HIBSCS], [SM] [111], [112], [113], [114], [115]
  CRP-cAMP repressor galEp2 Sigma70 -36.5 -67.5 galE, galT, galK, galM
acgattccacTAATTTATTCCATGTCACACTTttcgcatctt
792112 792133 [GEA], [HIBSCS], [SM] [111], [112], [113], [114], [115]
  CRP-cAMP activator galPp Sigma70 -42.5 -71.5 galP
gcgattacacTGATGTGATTTGCTTCACATCTttttacgtcg
3088202 3088223 [GEA], [HIBSCS] [115], [116]
  CRP-cAMP activator galSp Sigma70 -42.5 -84.5 galS
ccgtttccatTGCTGTGACTCGATTCACGAAGtcctgtattc
2241742 2241763 [AIBSCS], [BCE], [GEA], [HIBSCS] [33], [115], [116], [117]
  CRP-cAMP activator gapAp3 Sigma70 -41.5 -215.5 gapA
gctgcacctaAATCGTGATGAAAATCACATTTttatcgtaat
1862545 1862566 [GEA], [HIBSCS] [118]
  CRP-cAMP activator gatYp Sigma70 -40.5 -70.5 gatY, gatZ, gatA, gatB, gatC, gatD
atattgtcgtTTTTGTGATCGTTATCTCGATAtttaaaaaca
2177264 2177285 [AIBSCS], [BCE], [GEA], [SM] [9], [33]
  CRP-cAMP repressor gcdp1 Sigma70 -31.5 -69.5 gcd
ataaagctcgAATTGTGATGACGATCACACATgttaaaacct
141284 141305 [BPP], [GEA], [HIBSCS], [SM] [119], [120]
  CRP-cAMP activator gcvTp Sigma70 -313.5 -418.5 gcvT, gcvH, gcvP
cctctgttgtTTATTTGATACCCATCACACTTtcatctcccg
3051075 3051096 [BPP], [GEA], [HIBSCS], [SM] [121]
  CRP-cAMP activator gcvTp Sigma70 -145.5 -250.5 gcvT, gcvH, gcvP
gtcttattcaAATTGACTTTCTCATCACATCAtctttgtata
3050907 3050928 [BPP], [GEA], [HIBSCS], [SM] [121]
  CRP-cAMP repressor gdhAp1 Sigma70 -32.5 -95.5 gdhA
gggtcattttTTTCTTGCTTACCGTCACATTCttgatggtat
1842265 1842286 [HIBSCS] [122]
  CRP-cAMP activator glcCp Sigma70 -18.5 -84.5 glcC
ggttaactcaATGTTAAATTGATGTAACATAAtcacttacgt
3128177 3128198 [AIBSCS], [GEA] [33]
  CRP-cAMP activator glgCp1 Sigma70 nd nd glgC, glgA, glgP nd nd [BPP], [GEA] [123]
  CRP-cAMP activator glgSp1 Sigma38 -40.5 -113.5 glgS
tttcactaaaAAGTGTGATCGGGGACAATATAtttacgcacg
3192042 3192063 [GEA], [HIBSCS] [124]
  CRP-cAMP activator glnAp1 Sigma70 -71.5 -259.5 glnA, glnL, glnG
ttgcagagtcCCTTTGTGATCGCTTTCACGGAgcataaaaag
4058283 4058304 [HIBSCS] [125]
  CRP-cAMP repressor glnAp2 Sigma54 -57.5 -130.5 glnA, glnL, glnG
ccttttgcacGATGGTGCGCATGATAACGCCTtttaggggca
4058154 4058175 [AIBSCS], [BPP], [GEA] [126]
  CRP-cAMP repressor glnAp2 Sigma54 -55.5 -128.5 glnA, glnL, glnG
ttttgcacgaTGGTGCGCATGATAACGCCTTTtaggggcaat
4058152 4058173 [AIBSCS], [BPP], [GEA] [126]
  CRP-cAMP activator glpABCp Sigma70 -90.5 -154.5 glpA, glpB, glpC
ttcataaattAAATGTGAATTGCCGCACACATtattaaataa
2352482 2352503 [AIBSCS], [BPP], [GEA], [HIBSCS] [33], [127], [128], [129]
  CRP-cAMP activator glpABCp Sigma70 -40.5 -104.5 glpA, glpB, glpC
aaatgttcaaAATGACGCATGAAATCACGTTTcactttcgaa
2352532 2352553 [BPP], [GEA], [HIBSCS] [127], [128], [129]
  CRP-cAMP activator glpABCp Sigma70 -0.5 -64.5 glpA, glpB,