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Lrp DNA-binding transcriptional dual regulator

Synonyms: Lrp, Lrp-leucine
Summary:
Lrp, "Leucine-responsive regulatory protein," is a dual transcriptional regulator for at least 10% of the genes in Escherichia coli [58] These genes are involved in amino acid biosynthesis and catabolism, nutrient transport, pili synthesis, and other cellular functions, including 1-carbon metabolism [2, 5, 59] In addition, Lrp affects nearly three-fourths of the genes induced upon entry into stationary phase [58, 60] Lrp might also play a topological role in dynamic DNA packaging [] Lrp can act as a repressor or activator for its target genes. Binding of leucine can affect these activities in three different ways: leucine either potentiates, antagonizes, or has no discernible effect upon Lrp action [30, 41] It is believed that Lrp senses the presence of rich nutrition based on the concentration of leucine and positively regulates genes that function during famine and negatively regulates genes that function during a feast [59] Lrp forms a mixture of octamers and hexadecamers [] In the presence of leucine, the octamer configuration is favored.
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Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
Lrp Functional   nd [1], [2], [3], [4]
Lrp-leucine Functional Allosteric Holo [APPHINH], [HIFS] [4], [5], [6], [7]
Evolutionary Family: AsnC
Sensing class: Sensing external and internal signals
Connectivity class: Global Regulator
Gene name: lrp
  Genome position: 932595-933089
  Length: 495 bp / 164 aa
Operon name: lrp
TU(s) encoding the TF:
Transcription unit        Promoter
lrp
lrpp


Regulon       
Regulated gene(s) adhE, aidB, alaA, alaE, alaT, alaU, alaV, argO, aroA, avtA, cadA, cadB, csiD, dadA, dadX, fau, fimA, fimC, fimD, fimE, fimF, fimG, fimH, fimI, gabD, gabP, gabT, gcvH, gcvP, gcvT, gltB, gltD, gltF, gltT, gltU, gltV, gltW, hdeA, hdeB, ileT, ileU, ileV, ilvA, ilvD, ilvE, ilvG_1, ilvG_2, ilvH, ilvI, ilvL, ilvM, ilvX, kbl, leuE, lhgO, livF, livG, livH, livJ, livK, livM, lrp, lysP, lysU, malT,
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Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
rRNA, stable RNA (22)
translation (22)
ribosomes (22)
isoleucine/valine (13)
tRNA (11)
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Regulated operon(s) adhE, aidB, alaA-yfbR, alaE, argO, avtA, cadBA, csiD-lhgO-gabDTP, dadAX, fimAICDFGH, fimE, gcvTHP, gltBDF, hdeAB-yhiD, ilvIH, ilvLXG_1G_2MEDA, kbl-tdh, leuE, livJ, livKHMGF, lrp, lysP, lysU, malT, micF, ompC, oppABCDF, osmC, osmY, rrsA-ileT-alaT-rrlA-rrfA, rrsB-gltT-rrlB-rrfB, rrsC-gltU-rrlC-rrfC, rrsD-ileU-alaU-rrlD-rrfD-thrV-rrfF, rrsE-gltV-rrlE-rrfE, rrsG-gltW-rrlG-rrfG, rrsH-ileV-alaV-rrlH-rrfH, sdaA, serA, serC-aroA, ssrS-fau, stpA, yeiL, yojI
First gene in the operon(s) adhE, aidB, alaA, alaE, argO, avtA, cadB, csiD, dadA, dadA, dadA, fimA, fimE, gcvT, gltB, hdeA, ilvI, ilvI, ilvL, ilvL, kbl, leuE, livJ, livK, lrp, lysP, lysU, malT, micF, ompC, ompC, ompC, oppA, osmC, osmC, osmY, rrsA, rrsB, rrsC, rrsD, rrsE, rrsG, rrsH, sdaA, serA, serA, serC, serC, ssrS, ssrS, ssrS, ssrS, stpA, yeiL, yojI
Simple and complex regulons AcrR,H-NS,HU,IHF,Lrp,MarA,OmpR,Rob,SoxS
Ada,AidB,Lrp
AdiY,ArgR,CRP,FNR,Fur,GadE,HdfR,IHF,Lrp,Nac
ArcA,CadC,GadE-RcsB,GadX,H-NS,Lrp
ArcA,Fur,Lrp,ModE
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Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)
[Lrp,+](12)
[Lrp,-](20)


Transcription factor regulation    


Transcription factor binding sites (TFBSs) arrangements
      

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  Lrp repressor adhEp1 Sigma38, Sigma70 -157.0 -449.5 adhE
cttatttatgGCTAACATTATCCGGcttttgcttc
1298563 1298578 [AIBSCS], [GEA] [8]
  Lrp repressor adhEp1 Sigma38, Sigma70 -65.0 -357.5 adhE
actagataacAATAACGAATGATagcaatttta
1298472 1298485 [AIBSCS], [GEA] [8]
  Lrp repressor adhEp1 Sigma38, Sigma70 -6.0 -298.5 adhE
atagctaacaGTTAATAAATTGTAGtatgatttgg
1298412 1298427 [AIBSCS], [GEA] [8]
  Lrp repressor aidBp Sigma70, Sigma38 nd -4414275.0 aidB nd nd [BPP], [HIBSCS] [9]
  Lrp-leucine repressor alaAp9 Sigma32 nd -2407561.0 alaA nd nd [GEA] [10]
  Lrp-leucine activator alaEp Sigma70 -58.0 -137.5 alaE
atattttatcTACAAAAACTGACTAaataaaaatt
2799019 2799034 [BCE], [BPP], [GEA], [HIBSCS] [11], [12], [13]
  Lrp-leucine activator alaEp Sigma70 -9.0 -88.5 alaE
tagtcatagcCAGCGATATACGCTAtgcgaaaatg
2799068 2799083 [BCE], [BPP], [GEA], [HIBSCS] [11], [12], [13]
  Lrp-leucine activator argOp Sigma70 -89.5 -118.0 argO
agagagaggcCAGAGAGTATTATCTGgcctcagcgt
3068918 3068934 [BPP], [GEA] [14]
  Lrp-leucine activator argOp Sigma70 -65.5 -94.0 argO
aattggcaatCAGAAAAACTAATAAGagagaggcca
3068894 3068910 [BPP], [HIBSCS] [14]
  Lrp-leucine activator argOp Sigma70 -44.5 -73.0 argO
ttagcggaaaTTGATAATATTAATTGgcaatcagaa
3068873 3068889 [BPP], [HIBSCS] [14]
  Lrp-leucine repressor avtAp nd nd -3739705.0 avtA nd nd [GEA] [10]
  Lrp activator cadBp Sigma70 nd 4360031.0 cadB, cadA nd nd [BPP], [GEA] [15]
  Lrp-leucine activator csiDp Sigma38 nd -2788985.0 csiD, lhgO, gabD, gabT, gabP nd nd [BPP], [GEA] [16]
  Lrp repressor dadAp1 Sigma70 -250.0 -312.0 dadA, dadX
acgcgcacctCATTGTTGTCGGCGCtctctgtgtg
1237252 1237266 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp1 Sigma70 -225.0 -287.0 dadA, dadX
tctctgtgtgGAGCACCTCATTTCAagcatagaac
1237277 1237291 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp1 Sigma70 -177.0 -239.0 dadA, dadX
cgcgtcgccgGAGAATTTTTTTCTTtgcgatttct
1237325 1237339 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp1 Sigma70 -146.0 -208.0 dadA, dadX
ttcttattatCAGAGTGCCACTAATccgcttctga
1237356 1237370 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp1 Sigma70 -120.0 -182.0 dadA, dadX
cgcttctgaaCGGAATTTTATGCTGgataaaaagg
1237382 1237396 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp1 Sigma70 -90.0 -152.0 dadA, dadX
aaagggcgttCAGCAGGAGATACTAaagacgccat
1237412 1237426 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp1 Sigma70 -52.0 -114.0 dadA, dadX
gccgcagagtCAGGGAGATGTGAGCcagctcacca
1237450 1237464 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp1 Sigma70 -7.0 -69.0 dadA, dadX
gcatgttgaaTAATATTTTCAACTGagttatcaag
1237495 1237509 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp1 Sigma70 26.0 -37.0 dadA, dadX
aagatgtgatTAGATTATTATTCTTttactgtatc
1237527 1237541 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp1 Sigma70 73.0 10.0 dadA, dadX
agtggctatgCGAGTTGTCATACTGggaagtggtg
1237574 1237588 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp1 Sigma70 95.0 32.0 dadA, dadX
ctgggaagtgGTGTGGTAGGCGTTGccagcgcctg
1237596 1237610 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp2 Sigma70 -266.0 -312.0 dadA, dadX
acgcgcacctCATTGTTGTCGGCGCtctctgtgtg
1237252 1237266 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp2 Sigma70 -241.0 -287.0 dadA, dadX
tctctgtgtgGAGCACCTCATTTCAagcatagaac
1237277 1237291 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp2 Sigma70 -193.0 -239.0 dadA, dadX
cgcgtcgccgGAGAATTTTTTTCTTtgcgatttct
1237325 1237339 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp2 Sigma70 -162.0 -208.0 dadA, dadX
ttcttattatCAGAGTGCCACTAATccgcttctga
1237356 1237370 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp2 Sigma70 -136.0 -182.0 dadA, dadX
cgcttctgaaCGGAATTTTATGCTGgataaaaagg
1237382 1237396 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp2 Sigma70 -106.0 -152.0 dadA, dadX
aaagggcgttCAGCAGGAGATACTAaagacgccat
1237412 1237426 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp2 Sigma70 -68.0 -114.0 dadA, dadX
gccgcagagtCAGGGAGATGTGAGCcagctcacca
1237450 1237464 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp2 Sigma70 -23.0 -69.0 dadA, dadX
gcatgttgaaTAATATTTTCAACTGagttatcaag
1237495 1237509 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp2 Sigma70 10.0 -37.0 dadA, dadX
aagatgtgatTAGATTATTATTCTTttactgtatc
1237527 1237541 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp2 Sigma70 57.0 10.0 dadA, dadX
agtggctatgCGAGTTGTCATACTGggaagtggtg
1237574 1237588 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp2 Sigma70 79.0 32.0 dadA, dadX
ctgggaagtgGTGTGGTAGGCGTTGccagcgcctg
1237596 1237610 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp3 Sigma70 -279.0 -312.0 dadA, dadX
acgcgcacctCATTGTTGTCGGCGCtctctgtgtg
1237252 1237266 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp3 Sigma70 -254.0 -287.0 dadA, dadX
tctctgtgtgGAGCACCTCATTTCAagcatagaac
1237277 1237291 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp3 Sigma70 -206.0 -239.0 dadA, dadX
cgcgtcgccgGAGAATTTTTTTCTTtgcgatttct
1237325 1237339 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp3 Sigma70 -175.0 -208.0 dadA, dadX
ttcttattatCAGAGTGCCACTAATccgcttctga
1237356 1237370 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp3 Sigma70 -149.0 -182.0 dadA, dadX
cgcttctgaaCGGAATTTTATGCTGgataaaaagg
1237382 1237396 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp3 Sigma70 -119.0 -152.0 dadA, dadX
aaagggcgttCAGCAGGAGATACTAaagacgccat
1237412 1237426 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp3 Sigma70 -81.0 -114.0 dadA, dadX
gccgcagagtCAGGGAGATGTGAGCcagctcacca
1237450 1237464 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp3 Sigma70 -36.0 -69.0 dadA, dadX
gcatgttgaaTAATATTTTCAACTGagttatcaag
1237495 1237509 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp3 Sigma70 -4.0 -37.0 dadA, dadX
aagatgtgatTAGATTATTATTCTTttactgtatc
1237527 1237541 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp3 Sigma70 44.0 10.0 dadA, dadX
agtggctatgCGAGTTGTCATACTGggaagtggtg
1237574 1237588 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp repressor dadAp3 Sigma70 66.0 32.0 dadA, dadX
ctgggaagtgGTGTGGTAGGCGTTGccagcgcctg
1237596 1237610 [BPP], [GEA], [HIBSCS], [SM] [17], [18]
  Lrp activator fimAp Sigma70 173.0 -249.0 fimA, fimI, fimC, fimD, fimF, fimG, fimH
gacgcatcttCCTCATTCTTCTCTCcaaaaaccac
4542859 4542873 [BPP], [SM] [19]
  Lrp activator fimAp Sigma70 204.0 -218.0 fimA, fimI, fimC, fimD, fimF, fimG, fimH
ccacctcatgCAATATAAACATCTAtaaataaaga
4542890 4542904 [BPP], [HIBSCS], [SM] [19], [20]
  Lrp activator fimAp Sigma70 235.0 -187.0 fimA, fimI, fimC, fimD, fimF, fimG, fimH
aagataacaaTAGAATATTAAGCCAacaaataaac
4542921 4542935 [BPP], [HIBSCS], [SM] [19], [20]
  Lrp activator fimEp Sigma70 nd -4542037.0 fimE nd nd [GEA] [19], [20]
  Lrp activator gcvTp Sigma70 -161.0 -266.0 gcvT, gcvH, gcvP
gagaaagtcaATTTGAATAAGACAAtattaagagc
3050926 3050940 [GEA], [SM] [21], [22]
  Lrp activator gltBp Sigma70 -246.0 -462.0 gltB, gltD, gltF
aggcaaaaacAGTAGCATGAAACGTcattaccaat
3354256 3354270 [BPP], [HIBSCS], [SM] [2], [23], [24]
  Lrp activator gltBp Sigma70 -215.0 -431.0 gltB, gltD, gltF
caattaaggcAGTATAAAATGCTGGttttgtcgtc
3354287 3354301 [BPP], [HIBSCS], [SM] [23], [24], [25]
  Lrp activator gltBp Sigma70 -152.0 -368.0 gltB, gltD, gltF
cctttatgacAGTCAGGAATTGACTgtttctctaa
3354350 3354364 [BPP], [HIBSCS], [SM] [23], [24], [25]
  Lrp-leucine activator gltBp Sigma70 -108.0 -323.5 gltB, gltD, gltF
ttttagccttAAAGATAAAATCCATtttaatttca
3354394 3354409 [AIBSCS], [GEA] [8]
  Lrp-leucine repressor hdeAp Sigma38, Sigma70, Sigma70, Sigma38 -159.0 -210.5 hdeA, hdeB, yhiD
gacgcgttttTGGCATAGATTGATAgcaggggatt
3656943 3656958 [AIBSCS], [GEA] [26]
  Lrp-leucine repressor hdeAp Sigma38, Sigma70, Sigma70, Sigma38 -116.0 -167.5 hdeA, hdeB, yhiD
atactgcaatTAGGAAATTTTTATTaaatcgactg
3656900 3656915 [AIBSCS], [GEA] [26]
  Lrp-leucine repressor hdeAp Sigma38, Sigma70, Sigma70, Sigma38 -97.0 -148.5 hdeA, hdeB, yhiD
tgagttacagATGCATCAGATACTGcaattaggaa
3656881 3656896 [AIBSCS], [GEA] [26]
  Lrp-leucine repressor hdeAp Sigma38, Sigma70, Sigma70, Sigma38 -64.0 -115.5 hdeA, hdeB, yhiD
atatcaaaatCAGATATTTTTATTTcaatacaatg
3656848 3656863 [AIBSCS], [GEA] [26]
  Lrp-leucine repressor hdeAp Sigma38, Sigma70, Sigma70, Sigma38 -55.0 -106.5 hdeA, hdeB, yhiD
tgatggaaaaTATCAAAATCAGATAtttttatttc
3656839 3656854 [AIBSCS], [GEA] [26]
  Lrp-leucine repressor hdeAp Sigma38, Sigma70, Sigma70, Sigma38 -18.0 -69.5 hdeA, hdeB, yhiD
actgaggttaTAACCTGGTTTTCTGtatatgtcat
3656802 3656817 [AIBSCS], [GEA] [26]
  Lrp activator ilvIHp1 Sigma70 -252.0 -282.0 ilvI, ilvH
agacatgaatGTCTGGTTTATTCTGcattttttat
85341 85355 [BCE], [BPP], [GEA], [HIBSCS], [SM] [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
  Lrp activator ilvIHp1 Sigma70 -221.0 -251.0 ilvI, ilvH
ttattgaatgTAGAATTTTATTCTGaatgtgtggg
85372 85386 [BCE], [BPP], [GEA], [HIBSCS], [SM] [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
  Lrp activator ilvIHp1 Sigma70 -140.0 -170.0 ilvI, ilvH
ttgtgggattCAGCCGATTTATTATcaatttaatc
85453 85467 [BCE], [BPP], [GEA], [HIBSCS], [SM] [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
  Lrp activator ilvIHp1 Sigma70 -105.0 -135.0 ilvI, ilvH
ctctgtaatgGAGGATTTTATCGTTtcttttcacc
85488 85502 [BCE], [BPP], [GEA], [HIBSCS], [SM] [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
  Lrp activator ilvIHp1 Sigma70 -76.0 -106.0 ilvI, ilvH
ttcacctttcCTCCTGTTTATTCTTattaccccgt
85517 85531 [BCE], [BPP], [GEA], [HIBSCS], [SM] [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
  Lrp activator ilvIHp1 Sigma70 -56.0 -86.0 ilvI, ilvH
ttcttattacCCCGTGTTTATGTCTctggctgcca
85537 85551 [BCE], [BPP], [GEA], [HIBSCS], [SM] [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
  Lrp repressor ilvIp2 nd -192.0 -282.0 ilvI, ilvH
agacatgaatGTCTGGTTTATTCTGcattttttat
85341 85355 [BCE], [BPP], [GEA], [HIBSCS], [SM] [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
  Lrp repressor ilvIp2 nd -161.0 -251.0 ilvI, ilvH
ttattgaatgTAGAATTTTATTCTGaatgtgtggg
85372 85386 [BCE], [BPP], [GEA], [HIBSCS], [SM] [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
  Lrp repressor ilvIp2 nd -80.0 -170.0 ilvI, ilvH
ttgtgggattCAGCCGATTTATTATcaatttaatc
85453 85467 [BCE], [BPP], [GEA], [HIBSCS], [SM] [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
  Lrp repressor ilvIp2 nd -45.0 -135.0 ilvI, ilvH
ctctgtaatgGAGGATTTTATCGTTtcttttcacc
85488 85502 [BCE], [BPP], [GEA], [HIBSCS], [SM] [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
  Lrp repressor ilvIp2 nd -16.0 -106.0 ilvI, ilvH
ttcacctttcCTCCTGTTTATTCTTattaccccgt
85517 85531 [BCE], [BPP], [GEA], [HIBSCS], [SM] [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
  Lrp repressor ilvIp2 nd 5.0 -86.0 ilvI, ilvH
ttcttattacCCCGTGTTTATGTCTctggctgcca
85537 85551 [BCE], [BPP], [GEA], [HIBSCS], [SM] [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
  Lrp-leucine repressor ilvLp2 Sigma70 167.5 134.5 ilvL, ilvX, ilvG_1, ilvG_2, ilvM, ilvE, ilvD, ilvA
aagacccccgCACCGAAAGGTCcgggggtttt
3950451 3950462 [SM] [37]
  Lrp repressor ilvLp2 Sigma70 200.0 167.0 ilvL, ilvX, ilvG_1, ilvG_2, ilvM, ilvE, ilvD, ilvA
tttttgacctTAAAAACATAACCGAggagcagaca
3950482 3950496 [SM] [37]
  Lrp repressor ilvLp2 Sigma70 232.0 199.0 ilvL, ilvX, ilvG_1, ilvG_2, ilvM, ilvE, ilvD, ilvA
acaatgaataACAGCACAAAATTCTgtttctcaag
3950514 3950528 [HIBSCS], [SM] [37]
  Lrp activator kblp Sigma70 -77.0 -103.0 kbl, tdh
aattcaggatAAATAACGTGTAACTtgatgtctct
3792647 3792661 [AIBSCS] [38]
  Lrp activator kblp Sigma70 -66.5 -92.0 kbl, tdh
cacttctgcaAAATTCAGGATAAATaacgtgtaac
3792636 3792650 [AIBSCS], [BPP], [GEA], [HIBSCS] [38], [39]
  Lrp-leucine repressor leuEp nd -73.5 -114.5 leuE
gatatcaaccCGATAATTGAATcattaatcag
1880868 1880879 [AIBSCS] [40]
  Lrp-leucine repressor leuEp nd -40.5 -81.5 leuE
cggcttagaaAGGAGAAAATCAggttttaacc
1880835 1880846 [AIBSCS] [40]
  Lrp-leucine repressor leuEp nd -6.5 -47.5 leuE
gcgattaaagGTGAATATGCTAaccaatctgt
1880801 1880812 [AIBSCS] [40]
  Lrp-leucine repressor leuEp nd 31.5 -10.5 leuE
gaacacattaACCTCTTTAATTatctttcgat
1880764 1880775 [AIBSCS] [40]
  Lrp-leucine repressor livJp Sigma70 -127.0 -230.5 livJ
cccaaaaaacAAAAACCCCGGActctcatcca
3599883 3599894 [BPP], [GEA], [HIBSCS], [SM] [3], [38], [41], [42]
  Lrp repressor livKp1 Sigma70 nd 3597560.0 livK, livH, livM, livG, livF nd nd [GEA] [3], [43]
  Lrp repressor lrpp Sigma70 -56.0 -323.0 lrp
aatatctggcATGTTGTACTAAAAAtcgatgtttt
932265 932279 [BCE], [SM] [44]
  Lrp-leucine repressor lrpp Sigma70 8.0 -259.5 lrp
aaacattcgaGGAAGAAAAAAAACAgtattcttat
932328 932343 [AIBSCS], [GEA] [8]
  Lrp-leucine repressor lrpp Sigma70 32.0 -235.5 lrp
cagtattcttATATGCGCATAACCATGcatgtaaata
932351 932368 [AIBSCS], [GEA] [8]
  Lrp repressor lrpp Sigma70 49.0 -219.0 lrp
ataaccatgcATGTAAATACCATGTttaccgtgct
932369 932383 [HIBSCS], [SM] [38], [41], [44]
  Lrp activator lysPp Sigma70 nd 2248532.0 lysP nd nd [BPP], [GEA] [15]
  Lrp repressor lysUp1 Sigma70 -58.0 -146.0 lysU
atcactaataAATAACCATCAAAATggtttaaatg
4354856 4354870 [HIBSCS], [SM] [38], [41], [45]
  Lrp activator malTp Sigma70 nd -3553085.0 malT nd nd [GEA] [42]
  Lrp repressor micFp Sigma70 27.5 26.0 micF
ttcagaaatgAATGACGGTAATAAAtaaagttaat
2313103 2313117 [BPP], [GEA] [2], [46], [47]
  Lrp repressor micFp Sigma70 58.5 57.0 micF
ggcatccggtTGAAATAGGGGTAAAcagacattca
2313134 2313148 [BPP], [GEA] [2], [46], [47]
  Lrp repressor micFp Sigma70 87.5 86.0 micF
taaagaagggTAAAAAAAACCGAATgcgaggcatc
2313163 2313177 [BPP], [GEA] [2], [46], [47]
  Lrp-leucine repressor micFp Sigma70 122.0 120.5 micF
acacttttcaTTATTCTGTGCTaccacagaaa
2313199 2313210 [BPP], [GEA] [46], [47]
  Lrp repressor ompCp1 Sigma70 -376.0 -457.0 ompC
acacttttcaTTATTCTGTGCTACCacagaaaaac
2313199 2313213 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp1 Sigma70 -340.5 -421.0 ompC
gatgcctcgcATTCGGTTTTTTTTAcccttcttta
2313163 2313177 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp1 Sigma70 -311.5 -392.0 ompC
tgaatgtctgTTTACCCCTATTTCAaccggatgcc
2313134 2313148 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp1 Sigma70 -280.5 -361.0 ompC
attaactttaTTTATTACCGTCATTcatttctgaa
2313103 2313117 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp1 Sigma70 -29.5 -110.0 ompC
ccaaaaatgcAGAATAATCCAACACgaatatgata
2312852 2312866 [AIBSCS], [BPP], [GEA] [2], [38], [47]
  Lrp repressor ompCp1 Sigma70 2.0 -80.0 ompC
ctcattaatcAGTCGGCAAGTCCATtctccccaaa
2312822 2312836 [BPP], [GEA] [2], [47]
  Lrp-leucine repressor ompCp1 Sigma70 64.5 -17.5 ompC
ttattaacccTCTGTTATATGCctttatttgc
2312761 2312772 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp1 Sigma70 86.0 4.0 ompC
gggacagtacTTTAACTTTCATGTTattaaccctc
2312738 2312752 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp2 nd -342.0 -457.0 ompC
acacttttcaTTATTCTGTGCTACCacagaaaaac
2313199 2313213 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp2 nd -306.5 -421.0 ompC
gatgcctcgcATTCGGTTTTTTTTAcccttcttta
2313163 2313177 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp2 nd -277.5 -392.0 ompC
tgaatgtctgTTTACCCCTATTTCAaccggatgcc
2313134 2313148 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp2 nd -246.5 -361.0 ompC
attaactttaTTTATTACCGTCATTcatttctgaa
2313103 2313117 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp2 nd -174.0 -289.0 ompC
cttaagtattTGACAGCACTGAATGtcaaaacaaa
2313031 2313045 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp2 nd 5.5 -110.0 ompC
ccaaaaatgcAGAATAATCCAACACgaatatgata
2312852 2312866 [AIBSCS], [BPP], [GEA] [2], [38], [47]
  Lrp repressor ompCp2 nd 36.0 -80.0 ompC
ctcattaatcAGTCGGCAAGTCCATtctccccaaa
2312822 2312836 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp2 nd 98.5 -17.0 ompC
tgttattaacCCTCTGTTATATGCCtttatttgct
2312759 2312773 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp2 nd 120.0 4.0 ompC
gggacagtacTTTAACTTTCATGTTattaaccctc
2312738 2312752 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp3 nd -319.0 -457.0 ompC
acacttttcaTTATTCTGTGCTACCacagaaaaac
2313199 2313213 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp3 nd -283.5 -421.0 ompC
gatgcctcgcATTCGGTTTTTTTTAcccttcttta
2313163 2313177 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp3 nd -254.5 -392.0 ompC
tgaatgtctgTTTACCCCTATTTCAaccggatgcc
2313134 2313148 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp3 nd -223.5 -361.0 ompC
attaactttaTTTATTACCGTCATTcatttctgaa
2313103 2313117 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp3 nd -151.0 -289.0 ompC
cttaagtattTGACAGCACTGAATGtcaaaacaaa
2313031 2313045 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp3 nd 28.0 -111.0 ompC
caaaaatgcaGAATAATCCAACACGaatatgatac
2312853 2312867 [AIBSCS], [BPP], [GEA] [2], [38], [47]
  Lrp repressor ompCp3 nd 59.0 -80.0 ompC
ctcattaatcAGTCGGCAAGTCCATtctccccaaa
2312822 2312836 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp3 nd 121.5 -17.0 ompC
tgttattaacCCTCTGTTATATGCCtttatttgct
2312759 2312773 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp3 nd 143.0 4.0 ompC
gggacagtacTTTAACTTTCATGTTattaaccctc
2312738 2312752 [BPP], [GEA] [2], [47]
  Lrp repressor oppAp Sigma28 -1818.0 -1915.0 oppA, oppB, oppC, oppD, oppF
tttcaaatgaAACGGAGCTGCCATGctccgtttac
1299260 1299274 [BPP] [38], [48]
  Lrp repressor osmCp1 Sigma70 -52.0 -81.0 osmC
aatattttcgCCGGATTTTATTCGGaatatcctgc
1556537 1556551 [BPP], [GEA], [HIBSCS], [SM] [49]
  Lrp activator osmCp2 Sigma38 -62.0 -81.0 osmC
aatattttcgCCGGATTTTATTCGGaatatcctgc
1556537 1556551 [BPP], [GEA], [HIBSCS], [SM] [49]
  Lrp repressor osmYp Sigma70, Sigma38 -186.0 -429.0 osmY
ctggcacaggAACGTTATCCGGACGttcagttcca
4610960 4610974 [BPP], [GEA], [HIBSCS] [50], [51]
  Lrp repressor osmYp Sigma70, Sigma38 -149.0 -392.0 osmY
agacccgcgaGCATTAATTCTTGCCtccagggcgc
4610997 4611011 [BPP], [GEA], [HIBSCS] [50], [51]
  Lrp-leucine repressor rrsAp1 Sigma32, Sigma70 -73.0 -365.5 rrsA, ileT, alaT, rrlA, rrfA
ataagcataaAGAATAAAAAATgcgcggtcag
4035160 4035171 [BCE] [52]
  Lrp-leucine repressor rrsAp1 Sigma32, Sigma70 -53.0 -345.5 rrsA, ileT, alaT, rrlA, rrfA
atgcgcggtcAGAAAATTATTTtaaatttcct
4035180 4035191 [BPP] [52]
  Lrp-leucine repressor rrsBp1 Sigma32, Sigma70 -53.0 -345.5 rrsB, gltT, rrlB, rrfB
ttgcgcggtcAGAAAATTATTTtaaatttcct
4166308 4166319 [BPP], [GEA] [52]
  Lrp-leucine repressor rrsBp1 Sigma32, Sigma70 75.0 -218.5 rrsB, gltT, rrlB, rrfB
cggcagagaaAGCAAAAATAAAtgcttgactc
4166435 4166446 [BPP], [IEP] [52]
  Lrp-leucine repressor rrsBp1 Sigma32, Sigma70 269.0 -24.5 rrsB, gltT, rrlB, rrfB
aattcattacGAAGTTTAATTCtttgagcgtc
4166629 4166640 [BPP], [IEP] [52]
  Lrp-leucine repressor rrsCp1 Sigma32, Sigma70 nd -3941808.0 rrsC, gltU, rrlC, rrfC nd nd [BPP], [IDA] [52]
  Lrp-leucine repressor rrsDp1 Sigma32, Sigma70 nd 3428762.0 rrsD, ileU, alaU, rrlD, rrfD, thrV, rrfF nd nd [GEA] [52]
  Lrp-leucine repressor rrsEp Sigma32, Sigma70 nd -4208147.0 rrsE, gltV, rrlE, rrfE nd nd [GEA] [52]
  Lrp-leucine repressor rrsGp1 Sigma32, Sigma70 nd 2731157.0 rrsG, gltW, rrlG, rrfG nd nd [GEA] [52]
  Lrp-leucine repressor rrsHp1 Sigma32, Sigma70 nd -223771.0 rrsH, ileV, alaV, rrlH, rrfH nd nd [GEA] [52]
  Lrp repressor sdaAp Sigma32 nd -1896932.0 sdaA nd nd [AIBSCS] [38]
  Lrp activator serAp1 Sigma70 nd 3058410.0 serA nd nd [BPP], [GEA] [53]
  Lrp-leucine repressor serAp2 Sigma70 nd 3058410.0 serA nd nd [BPP], [GEA] [53]
  Lrp activator serCp Sigma70 -134.0 -192.0 serC, aroA
gggtgacctgACAGTAAAAACATCGgctttttgct
957454 957468 [GEA], [HIBSCS], [SM] [54]
  Lrp repressor ssrSp1 Sigma70 nd -3055983.0 ssrS, fau nd nd [BPP], [GEA] [55]
  Lrp repressor ssrSp2 Sigma38, Sigma70 nd -3055983.0 ssrS, fau nd nd [BPP], [GEA] [55]
  Lrp activator stpAp1 Sigma70 -539.0 -580.5 stpA
cattttcgcaTAGCGTATATCGCTGgctatgacta
2799068 2799083 [BCE], [BPP], [GEA], [HIBSCS] [11], [12], [13]
  Lrp activator stpAp1 Sigma70 -490.0 -531.5 stpA
aatttttattTAGTCAGTTTTTGTAgataaaatat
2799019 2799034 [BCE], [BPP], [GEA], [HIBSCS] [11], [12], [13]
  Lrp activator stpAp1 Sigma70 -107.0 -148.0 stpA
ctgaaactctCAGAATAATTTCAAGattatatatt
2798636 2798650 [BCE], [BPP], [GEA], [HIBSCS] [11], [13]
  Lrp-leucine activator yeiLp Sigma38 -120.0 -185.5 yeiL
atcacaatccAGAATAATTTTTctcttttcca
2255164 2255175 [GEA], [HIBSCS] [56]
  Lrp-leucine activator yojIp Sigma70 -412.5 -438.5 yojI
gttgacataaATTATGAAAACTctgtggcatg
2309048 2309059 [GEA], [ICWHO] [57]
  Lrp-leucine activator yojIp Sigma70 -304.5 -330.5 yojI
ccggttcgtcTTTATCCTGATGcagcgacagt
2308940 2308951 [GEA], [ICWHO] [57]
  Lrp-leucine activator yojIp Sigma70 -240.5 -266.5 yojI
aggccgccaaATTGAAAAATCGcgggtaagcc
2308876 2308887 [GEA], [ICWHO] [57]
  Lrp-leucine activator yojIp Sigma70 -194.5 -220.5 yojI
atcgccatgtTCCAACAACAAAcgtttgagcg
2308830 2308841 [GEA], [ICWHO] [57]
  Lrp-leucine activator yojIp Sigma70 -54.5 -80.5 yojI
aattcttattTTTATTCTTTTTtacctgcctg
2308690 2308701 [GEA], [ICWHO] [57]
  Lrp-leucine activator yojIp Sigma70 -43.5 -69.5 yojI
acagcaataaTAATTCTTATTTttattctttt
2308679 2308690 [GEA], [ICWHO] [57]