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Lrp DNA-binding transcriptional dual regulator

Synonyms: Lrp-leucine, Lrp
Summary:
Lrp, "Leucine-responsive regulatory protein," is a dual transcriptional regulator for at least 10% of the genes in Escherichia coli [60]. These genes are involved in amino acid biosynthesis and catabolism, nutrient transport, pili synthesis, and other cellular functions, including 1-carbon metabolism [2, 5, 61]. In addition, Lrp affects nearly three-fourths of the genes induced upon entry into stationary phase [52, 60]. Lrp might also play a topological role in dynamic DNA packaging []. Lrp can act as a repressor or activator for its target genes. Binding of leucine can affect these activities in three different ways: leucine either potentiates, antagonizes, or has no discernible effect upon Lrp action [30, 41]. It is believed that Lrp senses the presence of rich nutrition based on the concentration of leucine and positively regulates genes that function during famine and negatively regulates genes that function during a feast [61]. Lrp forms a mixture of octamers and hexadecamers [].
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Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
Lrp Functional   Apo nd [1], [2], [3], [4]
Lrp-leucine Functional Allosteric Holo [APPHINH], [HIFS] [4], [5], [6], [7]
Evolutionary Family: AsnC
Sensing class: Sensing external and internal signals
Connectivity class: Global Regulator
Gene name: lrp
  Genome position: 932595-933089
  Length: 495 bp / 164 aa
Operon name: lrp
TU(s) encoding the TF:
Transcription unit        Promoter
lrp
lrpp


Regulon       
Regulated gene(s) adhE, aidB, alaA, alaE, alaT, alaU, alaV, argO, aroA, avtA, cadA, cadB, dadA, dadX, fau, fimA, fimC, fimD, fimE, fimF, fimG, fimH, fimI, gabD, gabP, gabT, gcvH, gcvP, gcvT, glaH, gltB, gltD, gltF, gltT, gltU, gltV, gltW, hdeA, hdeB, ileT, ileU, ileV, ilvA, ilvD, ilvE, ilvG, ilvH, ilvI, ilvL, ilvM, ilvX, kbl, leuE, lhgD, livF, livG, livH, livJ, livK, livM, lrp, lysP, lysU, malT, micF,
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Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
rRNA, stable RNA (22)
translation (22)
ribosomes (22)
isoleucine/valine (13)
amino acids (12)
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Regulated operon(s) adhE, aidB, alaA-yfbR, alaE, argO, avtA, cadBA, dadAX, fimAICDFGH, fimE, gcvTHP, glaH-lhgD-gabDTP, gltBDF, hdeAB-yhiD, ilvIH, ilvLXGMEDA, kbl-tdh, leuE, livJ, livKHMGF, lrp, lysP, lysU, malT, micF, ompC, oppABCDF, osmC, osmY, ridA, rrsA-ileT-alaT-rrlA-rrfA, rrsB-gltT-rrlB-rrfB, rrsC-gltU-rrlC-rrfC, rrsD-ileU-alaU-rrlD-rrfD-thrV-rrfF, rrsE-gltV-rrlE-rrfE, rrsG-gltW-rrlG-rrfG, rrsH-ileV-alaV-rrlH-rrfH, sdaA, serA, serC-aroA, ssrS-fau, stpA, yeiL, yojI
First gene in the operon(s) adhE, aidB, alaA, alaE, argO, avtA, cadB, glaH, dadA, fimA, fimE, gcvT, gltB, hdeA, ilvI, ilvL, kbl, leuE, livJ, livK, lrp, lysP, lysU, malT, micF, ompC, oppA, osmC, osmY, ridA, rrsA, rrsB, rrsC, rrsD, rrsE, rrsG, rrsH, sdaA, serA, serC, ssrS, stpA, yeiL, yojI
Simple and complex regulons AcrR,H-NS,HU,IHF,Lrp,MarA,OmpR,Rob,SoxS
Ada,AidB,Lrp
AdiY,ArgR,CRP,FNR,Fur,GadE,HdfR,IHF,Lrp,Nac
ArcA,CadC,GadE-RcsB,GadX,H-NS,Lrp,OmpR
ArcA,Fur,Lrp,ModE
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Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)
[Lrp,-](33)
[Lrp,+](19)


Transcription factor regulation    


Transcription factor binding sites (TFBSs) arrangements
      

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  Lrp repressor adhEp1 Sigma38, Sigma70 -157.0 -449.0 adhE
cgaagcaaaaGCCGGATAATGTTAGCcataaataag
 1298563 1298578 [AIBSCS], [CV(GEA)], [GEA] [8]
  Lrp repressor adhEp1 Sigma38, Sigma70 -65.0 -357.0 adhE
ttaaaattgcTATCATTCGTTATTgttatctagt
 1298472 1298485 [AIBSCS], [CV(GEA)], [GEA] [8]
  Lrp repressor adhEp1 Sigma38, Sigma70 -6.0 -298.0 adhE
accaaatcatACTACAATTTATTAACtgttagctat
 1298412 1298427 [AIBSCS], [CV(GEA)], [GEA] [8]
  Lrp repressor aidBp Sigma70, Sigma38 nd nd aidB
nd
 nd nd [APIORCISFBSCS], [BPP] [9]
  Lrp-leucine repressor alaAp9 Sigma32 nd nd alaA
nd
 nd nd [GEA] [10]
  Lrp-leucine activator alaEp Sigma70 -58.0 -138.0 alaE
atattttatcTACAAAAACTGACTAAataaaaattt
 2799019 2799034 [APIORCISFBSCS], [BCE], [BPP], [CV(GEA)], [CV(GEA)], [GEA] [11], [12], [13]
  Lrp-leucine activator alaEp Sigma70 -9.0 -89.0 alaE
tagtcatagcCAGCGATATACGCTATgcgaaaatgc
 2799068 2799083 [APIORCISFBSCS], [BCE], [BPP], [CV(GEA)], [CV(GEA)], [GEA] [11], [12], [13]
  Lrp-leucine activator argOp Sigma70 -89.5 -117.5 argO
aacgctgaggCCAGATAATACTCTCTGgcctctctct
 3068918 3068934 [BPP], [GEA] [14]
  Lrp-leucine activator argOp Sigma70 -65.5 -93.5 argO
ctggcctctcTCTTATTAGTTTTTCTGattgccaatt
 3068894 3068910 [APIORCISFBSCS], [BPP] [14]
  Lrp-leucine activator argOp Sigma70 -44.5 -72.5 argO
tttctgattgCCAATTAATATTATCAAtttccgctaa
 3068873 3068889 [APIORCISFBSCS], [BPP] [14]
  Lrp-leucine repressor avtAp nd nd nd avtA
nd
 nd nd [GEA] [10]
  Lrp activator cadBp Sigma70 nd nd cadB, cadA
nd
 nd nd [BPP], [GEA] [15]
  Lrp-leucine activator csiDp Sigma38 nd nd glaH, lhgD, gabD, gabT, gabP
nd
 nd nd [BPP], [GEA] [16]
  Lrp repressor dadAp1 Sigma70 -250.0 -312.0 dadA, dadX
acgcgcacctCATTGTTGTCGGCGCtctctgtgtg
 1237252 1237266 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp1 Sigma70 -225.0 -287.0 dadA, dadX
tctctgtgtgGAGCACCTCATTTCAagcatagaac
 1237277 1237291 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp1 Sigma70 -177.0 -239.0 dadA, dadX
cgcgtcgccgGAGAATTTTTTTCTTtgcgatttct
 1237325 1237339 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp1 Sigma70 -146.0 -208.0 dadA, dadX
ttcttattatCAGAGTGCCACTAATccgcttctga
 1237356 1237370 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp1 Sigma70 -120.0 -182.0 dadA, dadX
cgcttctgaaCGGAATTTTATGCTGgataaaaagg
 1237382 1237396 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp1 Sigma70 -90.0 -152.0 dadA, dadX
aaagggcgttCAGCAGGAGATACTAaagacgccat
 1237412 1237426 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp1 Sigma70 -52.0 -114.0 dadA, dadX
gccgcagagtCAGGGAGATGTGAGCcagctcacca
 1237450 1237464 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp1 Sigma70 -7.0 -69.0 dadA, dadX
gcatgttgaaTAATATTTTCAACTGagttatcaag
 1237495 1237509 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp1 Sigma70 26.0 -37.0 dadA, dadX
aagatgtgatTAGATTATTATTCTTttactgtatc
 1237527 1237541 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp1 Sigma70 73.0 11.0 dadA, dadX
agtggctatgCGAGTTGTCATACTGggaagtggtg
 1237574 1237588 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp1 Sigma70 95.0 33.0 dadA, dadX
ctgggaagtgGTGTGGTAGGCGTTGccagcgcctg
 1237596 1237610 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp2 Sigma70 -266.0 -312.0 dadA, dadX
acgcgcacctCATTGTTGTCGGCGCtctctgtgtg
 1237252 1237266 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp2 Sigma70 -241.0 -287.0 dadA, dadX
tctctgtgtgGAGCACCTCATTTCAagcatagaac
 1237277 1237291 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp2 Sigma70 -193.0 -239.0 dadA, dadX
cgcgtcgccgGAGAATTTTTTTCTTtgcgatttct
 1237325 1237339 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp2 Sigma70 -162.0 -208.0 dadA, dadX
ttcttattatCAGAGTGCCACTAATccgcttctga
 1237356 1237370 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp2 Sigma70 -136.0 -182.0 dadA, dadX
cgcttctgaaCGGAATTTTATGCTGgataaaaagg
 1237382 1237396 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp2 Sigma70 -106.0 -152.0 dadA, dadX
aaagggcgttCAGCAGGAGATACTAaagacgccat
 1237412 1237426 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp2 Sigma70 -68.0 -114.0 dadA, dadX
gccgcagagtCAGGGAGATGTGAGCcagctcacca
 1237450 1237464 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp2 Sigma70 -23.0 -69.0 dadA, dadX
gcatgttgaaTAATATTTTCAACTGagttatcaag
 1237495 1237509 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp2 Sigma70 10.0 -37.0 dadA, dadX
aagatgtgatTAGATTATTATTCTTttactgtatc
 1237527 1237541 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp2 Sigma70 57.0 11.0 dadA, dadX
agtggctatgCGAGTTGTCATACTGggaagtggtg
 1237574 1237588 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp2 Sigma70 79.0 33.0 dadA, dadX
ctgggaagtgGTGTGGTAGGCGTTGccagcgcctg
 1237596 1237610 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp3 Sigma70 -279.0 -312.0 dadA, dadX
acgcgcacctCATTGTTGTCGGCGCtctctgtgtg
 1237252 1237266 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp3 Sigma70 -254.0 -287.0 dadA, dadX
tctctgtgtgGAGCACCTCATTTCAagcatagaac
 1237277 1237291 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp3 Sigma70 -206.0 -239.0 dadA, dadX
cgcgtcgccgGAGAATTTTTTTCTTtgcgatttct
 1237325 1237339 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp3 Sigma70 -175.0 -208.0 dadA, dadX
ttcttattatCAGAGTGCCACTAATccgcttctga
 1237356 1237370 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp3 Sigma70 -149.0 -182.0 dadA, dadX
cgcttctgaaCGGAATTTTATGCTGgataaaaagg
 1237382 1237396 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp3 Sigma70 -119.0 -152.0 dadA, dadX
aaagggcgttCAGCAGGAGATACTAaagacgccat
 1237412 1237426 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp3 Sigma70 -81.0 -114.0 dadA, dadX
gccgcagagtCAGGGAGATGTGAGCcagctcacca
 1237450 1237464 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp3 Sigma70 -36.0 -69.0 dadA, dadX
gcatgttgaaTAATATTTTCAACTGagttatcaag
 1237495 1237509 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp3 Sigma70 -4.0 -37.0 dadA, dadX
aagatgtgatTAGATTATTATTCTTttactgtatc
 1237527 1237541 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp3 Sigma70 44.0 11.0 dadA, dadX
agtggctatgCGAGTTGTCATACTGggaagtggtg
 1237574 1237588 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp repressor dadAp3 Sigma70 66.0 33.0 dadA, dadX
ctgggaagtgGTGTGGTAGGCGTTGccagcgcctg
 1237596 1237610 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [17], [18]
  Lrp activator fimAp Sigma70 173.0 -249.0 fimA, fimI, fimC, fimD, fimF, fimG, fimH
gacgcatcttCCTCATTCTTCTCTCcaaaaaccac
 4542859 4542873 [BPP], [CV(SM)], [SM] [19]
  Lrp activator fimAp Sigma70 204.0 -218.0 fimA, fimI, fimC, fimD, fimF, fimG, fimH
ccacctcatgCAATATAAACATCTAtaaataaaga
 4542890 4542904 [APIORCISFBSCS], [BPP], [CV(SM)], [SM] [19], [20]
  Lrp activator fimAp Sigma70 235.0 -187.0 fimA, fimI, fimC, fimD, fimF, fimG, fimH
aagataacaaTAGAATATTAAGCCAacaaataaac
 4542921 4542935 [APIORCISFBSCS], [BPP], [CV(SM)], [SM] [19], [20]
  Lrp activator fimEp Sigma70 nd nd fimE
nd
 nd nd [GEA] [19], [20]
  Lrp activator gcvTp Sigma70 -161.0 -266.0 gcvT, gcvH, gcvP
gctcttaataTTGTCTTATTCAAATtgactttctc
 3050926 3050940 [GEA], [SM] [21], [22]
  Lrp activator gltBp Sigma38, Sigma70 -246.0 -462.0 gltB, gltD, gltF
aggcaaaaacAGTAGCATGAAACGTcattaccaat
 3354256 3354270 [APIORCISFBSCS], [BPP], [CV(SM)], [SM] [2], [23], [24]
  Lrp activator gltBp Sigma38, Sigma70 -215.0 -431.0 gltB, gltD, gltF
caattaaggcAGTATAAAATGCTGGttttgtcgtc
 3354287 3354301 [APIORCISFBSCS], [BPP], [CV(SM)], [SM] [23], [24], [25]
  Lrp activator gltBp Sigma38, Sigma70 -152.0 -368.0 gltB, gltD, gltF
cctttatgacAGTCAGGAATTGACTgtttctctaa
 3354350 3354364 [APIORCISFBSCS], [BPP], [CV(SM)], [SM] [23], [24], [25]
  Lrp-leucine activator gltBp Sigma38, Sigma70 -108.0 -324.0 gltB, gltD, gltF
ttttagccttAAAGATAAAATCCATTttaatttcag
 3354394 3354409 [AIBSCS], [CV(GEA)], [GEA] [8]
  Lrp-leucine repressor hdeAp Sigma38, Sigma70, Sigma70, Sigma38 -159.0 -210.0 hdeA, hdeB, yhiD
aaatcccctgCTATCAATCTATGCCAaaaacgcgtc
 3656943 3656958 [AIBSCS], [CV(GEA)], [GEA] [26]
  Lrp-leucine repressor hdeAp Sigma38, Sigma70, Sigma70, Sigma38 -116.0 -167.0 hdeA, hdeB, yhiD
gcagtcgattTAATAAAAATTTCCTAattgcagtat
 3656900 3656915 [AIBSCS], [CV(GEA)], [GEA] [26]
  Lrp-leucine repressor hdeAp Sigma38, Sigma70, Sigma70, Sigma38 -97.0 -148.0 hdeA, hdeB, yhiD
tttcctaattGCAGTATCTGATGCATctgtaactca
 3656881 3656896 [AIBSCS], [CV(GEA)], [GEA] [26]
  Lrp-leucine repressor hdeAp Sigma38, Sigma70, Sigma70, Sigma38 -64.0 -115.0 hdeA, hdeB, yhiD
tcattgtattGAAATAAAAATATCTGattttgatat
 3656848 3656863 [AIBSCS], [CV(GEA)], [GEA] [26]
  Lrp-leucine repressor hdeAp Sigma38, Sigma70, Sigma70, Sigma38 -55.0 -106.0 hdeA, hdeB, yhiD
tgaaataaaaATATCTGATTTTGATAttttccatca
 3656839 3656854 [AIBSCS], [CV(GEA)], [GEA] [26]
  Lrp-leucine repressor hdeAp Sigma38, Sigma70, Sigma70, Sigma38 -18.0 -69.0 hdeA, hdeB, yhiD
catgacatatACAGAAAACCAGGTTAtaacctcagt
 3656802 3656817 [AIBSCS], [CV(GEA)], [GEA] [26]
  Lrp activator ilvIHp1 Sigma70 -252.0 -282.0 ilvI, ilvH
agacatgaatGTCTGGTTTATTCTGcattttttat
 85341 85355 [APIORCISFBSCS], [BCE], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
  Lrp activator ilvIHp1 Sigma70 -221.0 -251.0 ilvI, ilvH
ttattgaatgTAGAATTTTATTCTGaatgtgtggg
 85372 85386 [APIORCISFBSCS], [BCE], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
  Lrp activator ilvIHp1 Sigma70 -140.0 -170.0 ilvI, ilvH
ttgtgggattCAGCCGATTTATTATcaatttaatc
 85453 85467 [APIORCISFBSCS], [BCE], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
  Lrp activator ilvIHp1 Sigma70 -105.0 -135.0 ilvI, ilvH
ctctgtaatgGAGGATTTTATCGTTtcttttcacc
 85488 85502 [APIORCISFBSCS], [BCE], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
  Lrp activator ilvIHp1 Sigma70 -76.0 -106.0 ilvI, ilvH
ttcacctttcCTCCTGTTTATTCTTattaccccgt
 85517 85531 [APIORCISFBSCS], [BCE], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
  Lrp activator ilvIHp1 Sigma70 -56.0 -86.0 ilvI, ilvH
ttcttattacCCCGTGTTTATGTCTctggctgcca
 85537 85551 [APIORCISFBSCS], [BCE], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
  Lrp repressor ilvIp2 nd -192.0 -282.0 ilvI, ilvH
agacatgaatGTCTGGTTTATTCTGcattttttat
 85341 85355 [APIORCISFBSCS], [BCE], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
  Lrp repressor ilvIp2 nd -161.0 -251.0 ilvI, ilvH
ttattgaatgTAGAATTTTATTCTGaatgtgtggg
 85372 85386 [APIORCISFBSCS], [BCE], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
  Lrp repressor ilvIp2 nd -80.0 -170.0 ilvI, ilvH
ttgtgggattCAGCCGATTTATTATcaatttaatc
 85453 85467 [APIORCISFBSCS], [BCE], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
  Lrp repressor ilvIp2 nd -45.0 -135.0 ilvI, ilvH
ctctgtaatgGAGGATTTTATCGTTtcttttcacc
 85488 85502 [APIORCISFBSCS], [BCE], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
  Lrp repressor ilvIp2 nd -16.0 -106.0 ilvI, ilvH
ttcacctttcCTCCTGTTTATTCTTattaccccgt
 85517 85531 [APIORCISFBSCS], [BCE], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
  Lrp repressor ilvIp2 nd 5.0 -86.0 ilvI, ilvH
ttcttattacCCCGTGTTTATGTCTctggctgcca
 85537 85551 [APIORCISFBSCS], [BCE], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
  Lrp-leucine repressor ilvLp2 Sigma70 167.5 135.5 ilvL, ilvX, ilvG, ilvM, ilvE, ilvD, ilvA
aagacccccgCACCGAAAGGTCcgggggtttt
 3950451 3950462 [SM] [37]
  Lrp repressor ilvLp2 Sigma70 200.0 168.0 ilvL, ilvX, ilvG, ilvM, ilvE, ilvD, ilvA
tttttgacctTAAAAACATAACCGAggagcagaca
 3950482 3950496 [SM] [37]
  Lrp repressor ilvLp2 Sigma70 232.0 200.0 ilvL, ilvX, ilvG, ilvM, ilvE, ilvD, ilvA
acaatgaataACAGCACAAAATTCTgtttctcaag
 3950514 3950528 [APIORCISFBSCS], [SM] [37]
  Lrp activator kblp Sigma70 -77.0 -103.0 kbl, tdh
agagacatcaAGTTACACGTTATTTatcctgaatt
 3792647 3792661 [AIBSCS] [38]
  Lrp activator kblp Sigma70 -66.5 -92.5 kbl, tdh
gttacacgttATTTATCCTGAATTTtgcagaagtg
 3792636 3792650 [AIBSCS], [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] [38], [39]
  Lrp-leucine repressor leuEp nd -73.5 -114.5 leuE
ctgattaatgATTCAATTATCGggttgatatc
 1880868 1880879 [AIBSCS] [40]
  Lrp-leucine repressor leuEp nd -40.5 -81.5 leuE
ggttaaaaccTGATTTTCTCCTttctaagccg
 1880835 1880846 [AIBSCS] [40]
  Lrp-leucine repressor leuEp nd -6.5 -47.5 leuE
acagattggtTAGCATATTCACctttaatcgc
 1880801 1880812 [AIBSCS] [40]
  Lrp-leucine repressor leuEp nd 31.5 -10.5 leuE
atcgaaagatAATTAAAGAGGTtaatgtgttc
 1880764 1880775 [AIBSCS] [40]
  Lrp-leucine repressor livJp Sigma70 -127.0 -231.0 livJ
tggatgagagTCCGGGGTTTTTgttttttggg
 3599883 3599894 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [3], [38], [41], [42]
  Lrp repressor livKp1 Sigma70 nd nd livK, livH, livM, livG, livF
nd
 nd nd [GEA] [3], [43]
  Lrp repressor lrpp Sigma70 -56.0 -323.0 lrp
aatatctggcATGTTGTACTAAAAAtcgatgtttt
 932265 932279 [BCE], [SM] [44]
  Lrp-leucine repressor lrpp Sigma70 8.0 -260.0 lrp
aaacattcgaGGAAGAAAAAAAACAGtattcttata
 932328 932343 [AIBSCS], [CV(GEA)], [GEA] [8]
  Lrp-leucine repressor lrpp Sigma70 32.0 -236.0 lrp
cagtattcttATATGCGCATAACCATGCatgtaaatac
 932351 932368 [AIBSCS], [CV(GEA)], [GEA] [8]
  Lrp repressor lrpp Sigma70 49.0 -219.0 lrp
ataaccatgcATGTAAATACCATGTttaccgtgct
 932369 932383 [APIORCISFBSCS], [SM] [38], [41], [44]
  Lrp activator lysPp Sigma70 nd nd lysP
nd
 nd nd [BPP], [GEA] [15]
  Lrp repressor lysUp1 Sigma70 -58.0 -146.0 lysU
catttaaaccATTTTGATGGTTATTtattagtgat
 4354856 4354870 [APIORCISFBSCS], [SM] [38], [41], [45]
  Lrp activator malTp Sigma70 nd nd malT
nd
 nd nd [GEA] [42]
  Lrp repressor micFp Sigma38, Sigma70 27.5 27.5 micF
attaactttaTTTATTACCGTCATTcatttctgaa
 2313103 2313117 [BPP], [GEA] [2], [46], [47]
  Lrp repressor micFp Sigma38, Sigma70 58.5 58.5 micF
tgaatgtctgTTTACCCCTATTTCAaccggatgcc
 2313134 2313148 [BPP], [GEA] [2], [46], [47]
  Lrp repressor micFp Sigma38, Sigma70 87.5 87.5 micF
gatgcctcgcATTCGGTTTTTTTTAcccttcttta
 2313163 2313177 [BPP], [GEA] [2], [46], [47]
  Lrp-leucine repressor micFp Sigma38, Sigma70 122.0 122.0 micF
acacttttcaTTATTCTGTGCTaccacagaaa
 2313199 2313210 [BPP], [GEA] [46], [47]
  Lrp repressor ompCp1 Sigma70 -376.0 -457.0 ompC
gtttttctgtGGTAGCACAGAATAAtgaaaagtgt
 2313199 2313213 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp1 Sigma70 -340.5 -421.5 ompC
taaagaagggTAAAAAAAACCGAATgcgaggcatc
 2313163 2313177 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp1 Sigma70 -311.5 -392.5 ompC
ggcatccggtTGAAATAGGGGTAAAcagacattca
 2313134 2313148 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp1 Sigma70 -280.5 -361.5 ompC
ttcagaaatgAATGACGGTAATAAAtaaagttaat
 2313103 2313117 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp1 Sigma70 -29.5 -110.5 ompC
tatcatattcGTGTTGGATTATTCTgcatttttgg
 2312852 2312866 [AIBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] [2], [38], [47]
  Lrp repressor ompCp1 Sigma70 2.0 -80.0 ompC
tttggggagaATGGACTTGCCGACTgattaatgag
 2312822 2312836 [BPP], [GEA] [2], [47]
  Lrp-leucine repressor ompCp1 Sigma70 64.5 -17.5 ompC
gcaaataaagGCATATAACAGAgggttaataa
 2312761 2312772 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp1 Sigma70 86.0 5.0 ompC
gagggttaatAACATGAAAGTTAAAgtactgtccc
 2312738 2312752 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp2 nd -342.0 -457.0 ompC
gtttttctgtGGTAGCACAGAATAAtgaaaagtgt
 2313199 2313213 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp2 nd -306.5 -421.5 ompC
taaagaagggTAAAAAAAACCGAATgcgaggcatc
 2313163 2313177 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp2 nd -277.5 -392.5 ompC
ggcatccggtTGAAATAGGGGTAAAcagacattca
 2313134 2313148 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp2 nd -246.5 -361.5 ompC
ttcagaaatgAATGACGGTAATAAAtaaagttaat
 2313103 2313117 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp2 nd -174.0 -289.0 ompC
tttgttttgaCATTCAGTGCTGTCAaatacttaag
 2313031 2313045 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp2 nd 5.5 -110.5 ompC
tatcatattcGTGTTGGATTATTCTgcatttttgg
 2312852 2312866 [AIBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] [2], [38], [47]
  Lrp repressor ompCp2 nd 36.0 -80.0 ompC
tttggggagaATGGACTTGCCGACTgattaatgag
 2312822 2312836 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp2 nd 98.5 -17.5 ompC
agcaaataaaGGCATATAACAGAGGgttaataaca
 2312759 2312773 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp2 nd 120.0 5.0 ompC
gagggttaatAACATGAAAGTTAAAgtactgtccc
 2312738 2312752 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp3 nd -319.0 -457.0 ompC
gtttttctgtGGTAGCACAGAATAAtgaaaagtgt
 2313199 2313213 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp3 nd -283.5 -421.5 ompC
taaagaagggTAAAAAAAACCGAATgcgaggcatc
 2313163 2313177 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp3 nd -254.5 -392.5 ompC
ggcatccggtTGAAATAGGGGTAAAcagacattca
 2313134 2313148 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp3 nd -223.5 -361.5 ompC
ttcagaaatgAATGACGGTAATAAAtaaagttaat
 2313103 2313117 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp3 nd -151.0 -289.0 ompC
tttgttttgaCATTCAGTGCTGTCAaatacttaag
 2313031 2313045 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp3 nd 28.0 -111.0 ompC
gtatcatattCGTGTTGGATTATTCtgcatttttg
 2312853 2312867 [AIBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] [2], [38], [47]
  Lrp repressor ompCp3 nd 59.0 -80.0 ompC
tttggggagaATGGACTTGCCGACTgattaatgag
 2312822 2312836 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp3 nd 121.5 -17.5 ompC
agcaaataaaGGCATATAACAGAGGgttaataaca
 2312759 2312773 [BPP], [GEA] [2], [47]
  Lrp repressor ompCp3 nd 143.0 5.0 ompC
gagggttaatAACATGAAAGTTAAAgtactgtccc
 2312738 2312752 [BPP], [GEA] [2], [47]
  Lrp repressor oppAp Sigma28 -1818.0 -1915.0 oppA, oppB, oppC, oppD, oppF
tttcaaatgaAACGGAGCTGCCATGctccgtttac
 1299260 1299274 [BPP] [38], [48]
  Lrp repressor osmCp1 Sigma70 -52.0 -81.0 osmC
aatattttcgCCGGATTTTATTCGGaatatcctgc
 1556537 1556551 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [49]
  Lrp activator osmCp2 Sigma38 -62.0 -81.0 osmC
aatattttcgCCGGATTTTATTCGGaatatcctgc
 1556537 1556551 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [49]
  Lrp repressor osmYp Sigma70, Sigma38 -186.0 -429.0 osmY
ctggcacaggAACGTTATCCGGACGttcagttcca
 4610960 4610974 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] [50], [51]
  Lrp repressor osmYp Sigma70, Sigma38 -149.0 -392.0 osmY
agacccgcgaGCATTAATTCTTGCCtccagggcgc
 4610997 4611011 [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] [50], [51]
  Lrp activator ridAp nd -56.0 -89.0 ridA
agagttttccCATAATGTGGTGCTGgccaattaat
 4470995 4471009 [AIBSCS], [BPP], , [CV(GEA)], [CV(GEA)], [GEA] [52], [53]
  Lrp-leucine repressor rrsAp1 Sigma32, Sigma70 -73.0 -365.0 rrsA, ileT, alaT, rrlA, rrfA
ataagcataaAGAATAAAAAATgcgcggtcag
 4035160 4035171 [BCE] [54]
  Lrp-leucine repressor rrsAp1 Sigma32, Sigma70 -53.0 -345.0 rrsA, ileT, alaT, rrlA, rrfA
atgcgcggtcAGAAAATTATTTtaaatttcct
 4035180 4035191 [BPP] [54]
  Lrp-leucine repressor rrsBp1 Sigma32, Sigma70 -53.0 -345.0 rrsB, gltT, rrlB, rrfB
ttgcgcggtcAGAAAATTATTTtaaatttcct
 4166308 4166319 [BPP], [GEA] [54]
  Lrp-leucine repressor rrsBp1 Sigma32, Sigma70 75.0 -218.0 rrsB, gltT, rrlB, rrfB
cggcagagaaAGCAAAAATAAAtgcttgactc
 4166435 4166446 [BPP], [IEP] [54]
  Lrp-leucine repressor rrsBp1 Sigma32, Sigma70 269.0 -24.0 rrsB, gltT, rrlB, rrfB
aattcattacGAAGTTTAATTCtttgagcgtc
 4166629 4166640 [BPP], [IEP] [54]
  Lrp-leucine repressor rrsCp1 Sigma32, Sigma70 nd nd rrsC, gltU, rrlC, rrfC
nd
 nd nd [BPP], [IDA] [54]
  Lrp-leucine repressor rrsDp1 Sigma32, Sigma70 nd nd rrsD, ileU, alaU, rrlD, rrfD, thrV, rrfF
nd
 nd nd [GEA] [54]
  Lrp-leucine repressor rrsEp Sigma32, Sigma70 nd nd rrsE, gltV, rrlE, rrfE
nd
 nd nd [GEA] [54]
  Lrp-leucine repressor rrsGp1 Sigma32, Sigma70 nd nd rrsG, gltW, rrlG, rrfG
nd
 nd nd [GEA] [54]
  Lrp-leucine repressor rrsHp1 Sigma32, Sigma70 nd nd rrsH, ileV, alaV, rrlH, rrfH
nd
 nd nd [GEA] [54]
  Lrp repressor sdaAp Sigma32 nd nd sdaA
nd
 nd nd [AIBSCS] [38]
  Lrp activator serAp1 Sigma70 nd nd serA
nd
 nd nd [BPP], [GEA] [55]
  Lrp-leucine repressor serAp2 Sigma70 nd nd serA
nd
 nd nd [BPP], [GEA] [55]
  Lrp activator serCp Sigma70 -134.0 -192.0 serC, aroA
gggtgacctgACAGTAAAAACATCGgctttttgct
 957454 957468 [APIORCISFBSCS], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] [56]
  Lrp repressor ssrSp1 Sigma70 nd nd ssrS, fau
nd
 nd nd [BPP], [GEA] [57]
  Lrp repressor ssrSp2 Sigma38, Sigma70 nd nd ssrS, fau
nd
 nd nd [BPP], [GEA] [57]
  Lrp activator stpAp1 Sigma70 -539.0 -580.0 stpA
gcattttcgcATAGCGTATATCGCTGgctatgacta
 2799068 2799083 [APIORCISFBSCS], [BCE], [BPP], [CV(GEA)], [CV(GEA)], [GEA] [11], [12], [13]
  Lrp activator stpAp1 Sigma70 -490.0 -531.0 stpA
aaatttttatTTAGTCAGTTTTTGTAgataaaatat
 2799019 2799034 [APIORCISFBSCS], [BCE], [BPP], [CV(GEA)], [CV(GEA)], [GEA] [11], [12], [13]
  Lrp activator stpAp1 Sigma70 -107.0 -148.0 stpA
aatatataatCTTGAAATTATTCTGagagtttcag
 2798636 2798650 [APIORCISFBSCS], [BCE], [BPP], [CV(GEA)], [CV(GEA)], [GEA] [11], [13]
  Lrp-leucine activator yeiLp Sigma38 -120.0 -185.0 yeiL
atcacaatccAGAATAATTTTTctcttttcca
 2255164 2255175 [APIORCISFBSCS], [CV(GEA)], [GEA] [58]
  Lrp-leucine activator yojIp Sigma70 -412.5 -438.5 yojI
catgccacagAGTTTTCATAATttatgtcaac
 2309048 2309059 [CV(GEA)], [GEA], [ICWHO] [59]
  Lrp-leucine activator yojIp Sigma70 -304.5 -330.5 yojI
actgtcgctgCATCAGGATAAAgacgaaccgg
 2308940 2308951 [CV(GEA)], [GEA], [ICWHO] [59]
  Lrp-leucine activator yojIp Sigma70 -240.5 -266.5 yojI
ggcttacccgCGATTTTTCAATttggcggcct
 2308876 2308887 [CV(GEA)], [GEA], [ICWHO] [59]
  Lrp-leucine activator yojIp Sigma70 -194.5 -220.5 yojI
cgctcaaacgTTTGTTGTTGGAacatggcgat
 2308830 2308841 [CV(GEA)], [GEA], [ICWHO] [59]
  Lrp-leucine activator yojIp Sigma70 -54.5 -80.5 yojI
caggcaggtaAAAAAGAATAAAaataagaatt
 2308690 2308701 [CV(GEA)], [GEA], [ICWHO] [59]
  Lrp-leucine activator yojIp Sigma70 -43.5 -69.5 yojI
aaaagaataaAAATAAGAATTAttattgctgt
 2308679 2308690 [CV(GEA)], [GEA], [ICWHO] [59]