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Synonyms: MarA |
Summary:
MarA, "multiple antibiotic resistance" [24], participates in controlling several genes involved in resistance to antibiotics [25] oxidative stress [26], organic solvents [26, 27, 28], and heavy metals [26]. The antibiotic resistance associated with MarA appears to involve the acidification of the cytoplasm [25]. MarA, SoxS, and Rob are paralogous transcriptional regulators that show 45% amino acid identity between them [24]; the crystal structures for Rob [29]| and MarA [30] confirm this similarity between them. Read more > |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Evolutionary Family: | AraC/XylS | ||||||||||||
Connectivity class: | Local Regulator | ||||||||||||
Gene name: | marA | ||||||||||||
Genome position: | 1619574-1619957 | ||||||||||||
Length: | 384 bp / 127 aa | ||||||||||||
Operon name: | marRAB | ||||||||||||
TU(s) encoding the TF: |
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Transcription factor regulation |
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Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence![]() |
LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
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MarA | activator | acnAp2 | Sigma70 | -51.5 | -101.5 | acnA |
aaggtttctcCTCTTTTATCAATTTGGGTTGttatcaaatc
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1335720 | 1335740 | [GEA], [APIORCISFBSCS], [BPP], [CEEUMA], [IHBCE] | [1] | |
MarA | activator | acrAp | Sigma70 | -72.5 | -151.5 | acrA, acrB |
ttgcgcttctTGTTTGGTTTTTCGTGCCATatgttcgtga
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485761 | 485780 | [GEA], [AIBSCS], [APIORCISFBSCS], [BPP] | [2], [3] | |
MarA | activator | acrZp | Sigma70 | -40.5 | -62.5 | acrZ |
cgcaaagctgACCGCACAAAAGGGGAGTGCttttctgtgc
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794701 | 794720 | [GEA], [IHBCE] | [4] | |
MarA | activator | aldAp | Sigma70 | -161.0 | -203.0 | aldA |
gcgatggaaaGTCGCTCGTTACGTTAAAAAttgcccgttt
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1488019 | 1488038 | [GEA], [AIBSCS] | [1] | |
MarA | activator | decRp | Sigma70 | -65.0 | -96.0 | decR |
tttttgcgttGAATTTGTCATTTTGTGCCGtggtgtttaa
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468277 | 468296 | [AIBSCS] | [3] | |
MarA | activator | fprp | Sigma70 | -58.5 | -85.5 | fpr |
atcctctgatTGATTTGATCGATTGAGCCTtccagtcctt
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4114548 | 4114567 | [GEA], [AIBSCS], [APIORCISFBSCS], [BPP] | [5] | |
MarA | activator | fumCp2 | Sigma38 | -46.5 | -167.5 | fumC |
ttccagcagaTACAACTCACACAATGCACCcgctgtgtga
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1686746 | 1686765 | [GEA], [BPP] | [5], [6] | |
MarA | repressor | hdeAp | Sigma70 | -39.0 | -90.0 | hdeA, hdeB, yhiD |
tgattttgatATTTTCCATCAACATGACATatacagaaaa
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3656820 | 3656839 | [APPH], [GEA], [APIORCISFBSCS], [APPH], [SM] | [7] | |
MarA | repressor | hdeAp2 | Sigma38 | -39.0 | -90.0 | hdeA, hdeB, yhiD |
tgattttgatATTTTCCATCAACATGACATatacagaaaa
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3656820 | 3656839 | [APPH], [GEA], [APIORCISFBSCS], [APPH], [SM] | [7] | |
MarA | activator | inaAp | Sigma70 | -41.5 | -68.5 | inaA |
attcattaatACGACACGTTTCATTAAGATtttcctcagg
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2349531 | 2349550 | [GEA], [APIORCISFBSCS], [BPP] | [2], [6], [8] | |
MarA | repressor | lacZp1 | Sigma70 | -30.0 | -68.0 | lacZ, lacY, lacA |
ggcaccccagGCTTTACACTTTATGCttccggctcg
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366366 | 366381 | [GEA], [BPP], [SM] | [9] | |
MarA | activator | marRp | Sigma70 | -61.5 | -88.5 | marR, marA, marB |
acttgaaccgATTTAGCAAAACGTGGCATCggtcaattca
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1619022 | 1619041 | [GEA], [APIORCISFBSCS], [BPP], [SM] | [2], [5], [6], [10], [11] | |
MarA | activator | micFp1 | Sigma70 | -40.0 | -40.0 | micF |
aagtatttgaCAGCACTGAATGTCAAAACAaaaccttcac
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2313034 | 2313053 | [GEA], [AIBSCS], [APIORCISFBSCS], [BPP] | [5], [12] | |
MarA | activator | micFp2 | Sigma38 | -40.0 | -40.0 | micF |
aagtatttgaCAGCACTGAATGTCAAAACAaaaccttcac
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2313034 | 2313053 | [GEA], [AIBSCS], [APIORCISFBSCS], [BPP] | [5], [12] | |
MarA | activator | mlaFp2 | nd | -41.5 | -97.5 | mlaF, mlaE, mlaD, mlaC, mlaB |
taaaacaaatGCCAGCTTTCGCTAACcacggcgggt
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3340155 | 3340170 | [GEA], [BPP], [ICWHO] | [13] | |
MarA | activator | nfop | Sigma70 | -38.5 | -72.5 | nfo |
tcaaagcgtcATCGCATAAACCACTACATCttgctcctgt
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2250758 | 2250777 | [GEA], [APIORCISFBSCS] | [2], [14] | |
MarA | activator | nfsBp | Sigma70 | -43.5 | -72.5 | nfsB |
gcggaaatctATAGCGCATTTTTCTCGCTTaccatttctc
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605487 | 605506 | [GEA], [APIORCISFBSCS], [BPP] | [1], [15] | |
MarA | activator | poxBp1 | Sigma70 | -60.5 | -87.5 | poxB |
ttcatcgggcTATTTAACCGTTAGTGCCTCctttctctcc
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911127 | 911146 | [GEA], [APIORCISFBSCS] | [2] | |
MarA | activator | poxBp2 | Sigma38 | -60.5 | -87.5 | poxB |
ttcatcgggcTATTTAACCGTTAGTGCCTCctttctctcc
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911127 | 911146 | [GEA], [APIORCISFBSCS] | [2] | |
MarA | activator | pqiAp1 | Sigma70 | -42.5 | -377.5 | pqiA, pqiB, pqiC |
cgccgcggcaAAAGCAGAAACTGTAAAACGcagcagtagc
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1011614 | 1011633 | [GEA], [APIORCISFBSCS], [BPP] | [2], [8] | |
MarA | activator | pqiAp3 | Sigma38 | -42.5 | -377.5 | pqiA, pqiB, pqiC |
cgccgcggcaAAAGCAGAAACTGTAAAACGcagcagtagc
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1011614 | 1011633 | [GEA], [APIORCISFBSCS], [BPP] | [2], [8] | |
MarA | repressor | purAp | Sigma70 | -43.0 | -66.0 | purA |
cgaggtcattTTTGAGTGCAAAAAGTGCTGtaactctgaa
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4404611 | 4404630 | [GEA], [APIORCISFBSCS], [BPP], [SM] | [7] | |
MarA | activator | putAp | Sigma70 | nd | nd | putA | nd | nd | [GEA], [BPP] | [6] | ||
MarA | repressor | robp | nd | -20.0 | -63.0 | rob |
actgaatgctAAAACAGCAAAAAATGCTATtatccaatta
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4635363 | 4635382 | [GEA], [APIORCISFBSCS], [BPP], [SM] | [16] | |
MarA | repressor | slpp | Sigma70 | 39.0 | 14.0 | slp, dctR |
tagtaacatgAACATGACAAAAGGTGCACTcatcctcagc
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3653964 | 3653983 | [GEA], [APIORCISFBSCS] | [17], [18] | |
MarA | activator | sodAp | Sigma70 | -40.5 | -91.5 | sodA |
tacgaaaagtACGGCATTGATAATCATTTTcaatatcatt
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4100709 | 4100728 | [APIORCISFBSCS] | [2], [8], [14] | |
MarA | activator | tolCp3 | nd | -40.5 | -93.5 | tolC, ygiB, ygiC |
ttaacgccctATGGCACGTAACGCCAACCTtttgcggtag
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3178012 | 3178031 | [AIBSCS], [GEA], [AIBSCS] | [3], [19], [20] | |
MarA | activator | tolCp4 | Sigma38 | -52.5 | -93.5 | tolC, ygiB, ygiC |
ttaacgccctATGGCACGTAACGCCAACCTtttgcggtag
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3178012 | 3178031 | [GEA], [AIBSCS] | [3], [19], [20] | |
MarA | activator | waaYp | Sigma70 | -43.0 | -214.0 | waaY, waaZ |
gcaactaaacCGTGGCACAAATGGGCAATTtatccatcgg
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3801169 | 3801188 | [GEA], [APIORCISFBSCS] | [21] | |
MarA | activator | xseAp | Sigma70 | -42.0 | -77.0 | xseA |
atctacccctTTTTGCAAAAAATGCTtgctatcccc
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2634148 | 2634163 | [GEA], [BPP], [ICWHO] | [13] | |
MarA | activator | ybjCp | Sigma70 | -40.5 | -61.5 | ybjC, nfsA, rimK, ybjN |
ttaattgctaAAAGCTATAACTGTTAAACAcaatacagtg
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890842 | 890861 | [GEA], [AIBSCS], [APIORCISFBSCS], [CEEUMA], [RSE] | [1], [8] | |
MarA | activator | ycgZp | Sigma70 | -62.0 | -99.0 | ycgZ, ymgA, ariR, ymgC |
atatgcattaGCACTAATTGCAAAAAattaatttat
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1215683 | 1215698 | [AIBSCS], [BPP], [CSE], [SM] | [22] | |
MarA | activator | ycgZp2 | Sigma38 | -62.0 | -99.0 | ycgZ, ymgA, ariR, ymgC |
atatgcattaGCACTAATTGCAAAAAattaatttat
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1215683 | 1215698 | [AIBSCS], [BPP], [CSE], [SM] | [22] | |
MarA | activator | yncEp | nd | -41.5 | -121.5 | yncE |
tgtagtcgtaACGGCAAGAAATGCTCCACATttgagaaaat
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1523176 | 1523196 | [GEA], [APIORCISFBSCS] | [1] | |
MarA | activator | zwfp | Sigma70 | -54.0 | -116.0 | zwf |
gcttttcccgTAATCGCACGGGTGGATAAGcgtttacagt
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1936420 | 1936439 | [GEA], [APIORCISFBSCS], [BPP] | [2], [5], [14], [23] |
Functional conformation | Function | Object name | Object type | Distance to first Gene | Sequence | LeftPos | RightPos | Center Position | Growth Condition | Evidence (Confirmed, Strong, Weak) | References | |
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MarA | activator | mdaB | Transcription-Unit | -68.0 |
cgcaaaagacTTTGCACATTTTGCTAATTTcaccgtaccg
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3172452 | 3172471 | 3172462.0 | nd | [GEA], [AIBSCS] | [1] | |
MarA | activator | yhbW | Transcription-Unit | -66.0 |
gcctaagtaaATAGCTCACTTTGTTAACAActttaactac
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3303372 | 3303391 | 3303382.0 | nd | [GEA], [AIBSCS] | [1] | |
MarA | activator | map-glnD-dapD | Transcription-Unit | nd |
aatcattctgAATTTCGCCAAACGTGCCACtgaaggtttt
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189597 | 189616 | 189607.0 | nd | [GEA], [AIBSCS] | [1] |
Alignment and PSSM for MarA TFBSs | ![]() |
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Aligned TFBS of MarA |
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Sequence | |
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CACCACGGCACAAAATGACAAAT | |
CCCTATGGCACGTAACGCCAACC | |
ACATATGGCACGAAAAACCAAAC | |
CGTAACGGCAAGAAATGCTCCAC | |
AAAGGAGGCACTAACGGTTAAAT | |
TTTGACAGCACTGAATGTCAAAA | |
AACCGTGGCACAAATGGGCAATT | |
GCTAAAAGCTATAACTGTTAAAC | |
GCTGACCGCACAAAAGGGGAGTG | |
TAAAACAGCAAAAAATGCTATTA | |
CTGGAAGGCTCAATCGATCAAAT | |
ACCGATGCCACGTTTTGCTAAAT | |
GGCAAAAGCAGAAACTGTAAAAC | |
CGTCATCGCATAAACCACTACAT | |
CGTAATCGCACGGGTGGATAAGC | |
GAAAGTCGCTCGTTACGTTAAAA | |
ATGAACATGACAAAAGGTGCACT | |
AGTTACAGCACTTTTTGCACTCA | |
CCTTTTTGCAAAAAATGCTTGCT | |
AAGTACGGCATTGATAATCATTT | |
GGTAAGCGAGAAAAATGCGCTAT | |
GTGGTTAGCGAAAGCTGGCATTT | |
TAATACGACACGTTTCATTAAGA | |
AGATACAACTCACACAATGCACC | |
CCCAAATTGATAAAAGAGGAGAA | |
TATTTTCCATCAACATGACATAT |
Position weight matrix (PWM). MarA matrix-quality result |
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A 8 8 6 9 20 5 8 2 2 19 6 14 17 18 13 3 7 3 2 20 15 14 6 C 8 7 6 3 0 10 6 2 22 0 16 0 1 1 7 4 0 9 9 5 2 5 7 G 6 7 4 6 3 1 10 20 2 2 1 7 3 2 0 7 19 4 5 0 3 2 1 T 4 4 10 8 3 10 2 2 0 5 3 5 5 5 6 12 0 10 10 1 6 5 12 |
Consensus |
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; consensus.strict cgtaacgGCaCaaaatGccaaat ; consensus.strict.rc ATTTGGCATTTTGTGCCGTTACG ; consensus.IUPAC vvydayvGCaCraamkGyyaaay ; consensus.IUPAC.rc RTTTRRCMKTTYGTGCBRTHRBB ; consensus.regexp [acg][acg][ct][agt]a[ct][acg]GCaC[ag]aa[ac][gt]G[ct][ct]aaa[ct] ; consensus.regexp.rc [AG]TTT[AG][AG]C[AC][GT]TT[CT]GTGC[CGT][AG]T[ACT][AG][CGT][CGT] |
Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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