RegulonDB RegulonDB 9.3:Regulon Page

GlcC DNA-binding transcriptional dual regulator

Synonyms: GlcC-Acetate, GlcC-Glycolate, GlcC

Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
GlcC Non-Functional   Apo [BPP], [GEA] [1]
GlcC-Acetate Functional Allosteric Holo [BPP], [GEA] [1]
GlcC-Glycolate Functional Allosteric Holo [BPP], [GEA] [1]
Evolutionary Family: GntR
Sensing class: Sensing external and internal signals
Connectivity class: Local Regulator
Gene name: glcC
  Genome position: 3128272-3129036
  Length: 765 bp / 254 aa
Operon name: glcC
TU(s) encoding the TF:
Transcription unit        Promoter

Regulated gene(s) glcA, glcB, glcC, glcD, glcE, glcF, glcG
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
carbon compounds (3)
glycolate metabolism (3)
Porters (Uni-, Sym- and Antiporters) (1)
membrane (1)
glyoxylate degradation (1)
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Regulated operon(s) glcC, glcDEFGBA
First gene in the operon(s) glcC, glcD
Simple and complex regulons ArcA,GlcC,IHF,PdhR
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)

Transcription factor binding sites (TFBSs) arrangements       

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  GlcC-Glycolate repressor glcCp Sigma70 47.0 -20.0 glcC
3128245 3128259 [BCE], [GEA], [SM] [1]
  GlcC-Glycolate activator glcDp Sigma70 -176.0 -231.0 glcD, glcE, glcF, glcG, glcB, glcA
3128245 3128259 [BCE], [GEA], [SM] [1]

Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation


 [BPP] Binding of purified proteins

 [GEA] Gene expression analysis

 [BCE] Binding of cellular extracts

 [SM] Site mutation


 [1] Pellicer MT., Fernandez C., Badia J., Aguilar J., Lin EC., Baldom L., 1999, Cross-induction of glc and ace operons of Escherichia coli attributable to pathway intersection. Characterization of the glc promoter., J Biol Chem. 274(3):1745-52