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Synonyms: ArgR-L-arginine, ArgR |
Summary:
ArgR complexed with L-arginine represses the transcription of several genes involved in biosynthesis and transport of arginine, transport of histidine, and its own synthesis [1, 2, 4]and activates genes for arginine catabolism [12] ArgR is also essential for a site-specific recombination reaction that resolves plasmid ColE1 multimers to monomers and is necessary for plasmid stability [17]The role of ArgR in this latter reaction may be structural [17]br>The hexamer is the active form of ArgR, and L-arginine binds to ArgR and stabilizes the hexamer [18]nd increases its DNA affinity by allosteric activation [18, 19]. ArgR belongs to the ArgR/AhrC family, whose members are widely distributed in bacteria [5] The DNA sequence which the proteins of the family recognize and to which they bind are also well-conserved among genomes [5] This DNA sequence consists of a palindromic sequence of 18 bp, called the ARG box [4, 5] An ArgR hexamer binds to a pair of these boxes that are generally separated by 3 bp [4, 8] The repressor can bind to a single box but with a greatly reduced affinity [4, 8] The ARG box generally overlaps the promoter sequence and the transcriptional start site [4] therefore, it was suggested that it represses the transcription by steric exclusion of RNA polymerase binding [11] ArgR has two domains: the N-terminal domain, which contains a winged helix-turn-helix DNA-binding motif [20] and the C-terminal domain, which contains a motif that binds L-arginine and a motif for oligomerization [18] Based on cross-linking analysis of wild-type and mutant ArgR proteins, it has been shown that the C-terminus is more important in cer/Xer site-specific recombination than in DNA binding [21] Read more > |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Evolutionary Family: | ArgR | ||||||||||||||||||
Sensing class: | Sensing external and internal signals | ||||||||||||||||||
Connectivity class: | Local Regulator | ||||||||||||||||||
Gene name: | argR | ||||||||||||||||||
Genome position: | 3384703-3385173 | ||||||||||||||||||
Length: | 471 bp / 156 aa | ||||||||||||||||||
Operon name: | argR | ||||||||||||||||||
TU(s) encoding the TF: |
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Regulon |
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Regulated gene(s) | argA, argB, argC, argD, argE, argF, argG, argH, argI, argR, artI, artJ, artM, artP, artQ, astA, astB, astC, astD, astE, carA, carB, gltB, gltD, gltF, hisJ, hisM, hisP, hisQ, infB, lysO, metY, nusA, pnp, rbfA, rimP, rpsO, truB | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
arginine (19)
amino acids (6)
lysine (4)
ABC superfamily, membrane component (4)
membrane (4)
Read more >
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Regulated operon(s) | argA, argCBH, argD, argE, argF, argG, argI, argR, argT-hisJQMP, artJ, artPIQM, astCADBE, carAB, gltBDF, lysO, metY-rimP-nusA-infB-rbfA-truB-rpsO-pnp | ||||||
First gene in the operon(s) | argA, argC, argD, argE, argF, argG, argI, argR, artJ, artP, astC, carA, gltB, hisJ, lysO, metY, metY | ||||||
Simple and complex regulons | AdiY,ArgR,CRP,FNR,Fur,GadE,HdfR,IHF,Lrp,Nac ArgR ArgR,CRP ArgR,H-NS ArgR,NtrC Read more > | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
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ArgR-L-arginine | repressor | argAp | Sigma70 | 46.5 | -40.5 | argA |
ctgcgaaaaaACAGAATAAAAATACACTaatttcgaat
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2949193 | 2949210 | [AIBSCS], [BPP], [GEA], [HIBSCS] | [1], [4], [5] | |
ArgR-L-arginine | repressor | argAp | Sigma70 | 67.5 | -19.5 | argA |
atacactaatTTCGAATAATCATGCAAAgaggtgtgcc
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2949214 | 2949231 | [AIBSCS], [BPP], [GEA], [HIBSCS] | [1], [4], [5] | |
ArgR-L-arginine | repressor | argCp | Sigma70 | -3.5 | -119.5 | argC, argB, argH |
ggtcatgataGTATCAATATTCATGCAGtatttatgaa
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4154873 | 4154890 | [AIBSCS], [BCE], [BPP], [GEA], [SM] | [1], [4], [5], [6] | |
ArgR-L-arginine | repressor | argCp | Sigma70 | 19.5 | -97.5 | argC, argB, argH |
atgcagtattTATGAATAAAAATACACTaacgttgagc
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4154895 | 4154912 | [AIBSCS], [BCE], [BPP], [GEA], [SM] | [1], [4], [5], [6] | |
ArgR-L-arginine | repressor | argDp | Sigma70 | -19.5 | -60.5 | argD |
attgccatttAGTGATTTTTTATGCATAttttgtggtt
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3490232 | 3490249 | [AIBSCS], [BPP], [GEA], [HIBSCS] | [1], [4], [5] | |
ArgR-L-arginine | repressor | argDp | Sigma70 | 2.5 | -39.5 | argD |
atgcatatttTGTGGTTATAATTTCACAtttgtttatg
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3490211 | 3490228 | [AIBSCS], [BPP] | [1], [4], [5] | |
ArgR-L-arginine | repressor | argEp1 | Sigma70 | -6.5 | -56.5 | argE |
gctcaacgttAGTGTATTTTTATTCATAaatactgcat
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4154895 | 4154912 | [AIBSCS], [BCE], [BPP], [GEA], [SM] | [1], [4], [5], [6] | |
ArgR-L-arginine | repressor | argEp1 | Sigma70 | 16.5 | -34.5 | argE |
ttcataaataCTGCATGAATATTGATACtatcatgacc
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4154873 | 4154890 | [AIBSCS], [BCE], [BPP], [GEA], [SM] | [1], [4], [5], [6] | |
ArgR-L-arginine | repressor | argFp | Sigma70 | -22.5 | -57.5 | argF |
tggggttgcaAATGAATAATTACACATAtaaagtgaat
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290354 | 290371 | [AIBSCS], [BCE], [BPP], [GEA] | [1], [4], [5], [6], [7], [8], [9] | |
ArgR-L-arginine | repressor | argFp | Sigma70 | -1.5 | -36.5 | argF |
acacatataaAGTGAATTTTAATTCAATaagtggcgtt
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290333 | 290350 | [AIBSCS], [BPP], [GEA], [SM] | [1], [4], [5], [6], [8], [9] | |
ArgR-L-arginine | repressor | argGp | Sigma70 | -125.5 | -200.5 | argG |
ttgctaatcaTGTGAATGAATATCCAGTtcactttcat
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3318428 | 3318445 | [AIBSCS], [BPP], [GEA], [HIBSCS] | [1], [4], [5], [10] | |
ArgR-L-arginine | repressor | argGp | Sigma70 | -6.5 | -81.5 | argG |
ataaaagatgATTAAATGAAAACTCATTtattttgcat
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3318547 | 3318564 | [AIBSCS], [BPP], [GEA], [HIBSCS] | [1], [4], [5], [10] | |
ArgR-L-arginine | repressor | argGp | Sigma70 | 15.5 | -60.5 | argG |
actcatttatTTTGCATAAAAATTCAGTgagagcggaa
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3318568 | 3318585 | [AIBSCS], [BPP], [GEA], [HIBSCS] | [1], [4], [5], [10] | |
ArgR-L-arginine | repressor | argIp | Sigma70 | -22.5 | -55.5 | argI |
tagacttgcaAATGAATAATCATCCATAtaaattgaat
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4478358 | 4478375 | [AIBSCS], [BCE], [BPP], [GEA] | [1], [4], [5], [6] | |
ArgR-L-arginine | repressor | argIp | Sigma70 | -1.5 | -34.5 | argI |
atccatataaATTGAATTTTAATTCATTgaggcgttag
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4478337 | 4478354 | [AIBSCS], [BCE], [BPP], [GEA] | [1], [4], [5], [6] | |
ArgR-L-arginine | repressor | argRp1 | Sigma70 | -27.5 | -53.5 | argR |
gggctgactgTTTGCATAAAAATTCATCtgtatgcaca
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3384641 | 3384658 | [AIBSCS], [BPP], [GEA], [HIBSCS] | [1], [2], [4], [5], [7] | |
ArgR-L-arginine | repressor | argRp1 | Sigma70 | -7.5 | -33.5 | argR |
aattcatctgTATGCACAATAATGTTGTatcaaccacc
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3384661 | 3384678 | [AIBSCS], [BPP], [GEA], [HIBSCS] | [1], [2], [4], [5], [7] | |
ArgR-L-arginine | repressor | artJp | Sigma70 | -48.5 | -99.5 | artJ |
tttatttcatTTAAATTATTTAATCATGtttattgcat
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900666 | 900683 | [BPP], [GEA], [SM] | [11] | |
ArgR-L-arginine | repressor | artJp | Sigma70 | -27.5 | -78.5 | artJ |
aatcatgtttATTGCATATAAATTCACTtgatggcatt
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900645 | 900662 | [AIBSCS], [BPP], [GEA], [SM] | [1], [5], [11] | |
ArgR-L-arginine | repressor | artPp | Sigma70 | -50.5 | -85.5 | artP, artI, artQ, artM |
gcgctttgctTTTAACTTTTAAAGCAGAaatattgcat
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903811 | 903828 | [BPP], [GEA], [SM] | [11] | |
ArgR-L-arginine | repressor | artPp | Sigma70 | -29.5 | -64.5 | artP, artI, artQ, artM |
aagcagaaatATTGCATAATTATTCTGTcaaaggtact
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903790 | 903807 | [AIBSCS], [BPP], [GEA], [SM] | [1], [5], [11] | |
ArgR-L-arginine | activator | astCp2 | Sigma54 | -121.5 | -183.5 | astC, astA, astD, astB, astE |
attcacccacATCGCAAACGTATTCACTttatatgcac
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1832157 | 1832174 | [AIBSCS], [BPP], [GEA] | [12] | |
ArgR-L-arginine | activator | astCp2 | Sigma54 | -99.5 | -161.5 | astC, astA, astD, astB, astE |
ttcactttatATGCACTTTAAATGCATAtggtttggtt
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1832135 | 1832152 | [AIBSCS], [BPP], [GEA] | [12] | |
ArgR-L-arginine | activator | astCp2 | Sigma54 | -78.5 | -140.5 | astC, astA, astD, astB, astE |
atgcatatggTTTGGTTATAACTCCTTGatttccagtt
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1832114 | 1832131 | [AIBSCS], [BPP], [GEA] | [12] | |
ArgR-L-arginine | activator | astCp2 | Sigma54 | -47.5 | -109.5 | astC, astA, astD, astB, astE |
tccagttagcCTCCGCCGTTTATGCACTtttatcactg
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1832083 | 1832100 | [AIBSCS], [BPP], [GEA] | [12] | |
ArgR-L-arginine | repressor | carAp2 | Sigma70 | -8.5 | -40.5 | carA, carB |
acgtcatcatTGTGAATTAATATGCAAAtaaagtgagt
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29602 | 29619 | [AIBSCS], [BPP], [GEA], [HIBSCS], [SM] | [1], [4], [5], [13], [14] | |
ArgR-L-arginine | repressor | carAp2 | Sigma70 | 13.5 | -19.5 | carA, carB |
atgcaaataaAGTGAGTGAATATTCTCTggagggtgtt
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29623 | 29640 | [AIBSCS], [BPP], [GEA], [HIBSCS], [SM] | [1], [4], [5], [13], [14] | |
ArgR-L-arginine | repressor | gltBp | Sigma70 | -352.0 | -568.5 | gltB, gltD, gltF |
gcttttatcaACTGCATAATCAATCAAAattaccgaaa
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3354148 | 3354165 | [BPP], [GEA], [HIBSCS] | [15] | |
ArgR-L-arginine | repressor | gltBp | Sigma70 | -331.5 | -547.5 | gltB, gltD, gltF |
aatcaaaattACCGAAATTTCATGCATAatcacataaa
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3354169 | 3354186 | [BPP], [GEA], [HIBSCS] | [15] | |
ArgR-L-arginine | repressor | hisJp | Sigma70 | -83.5 | -132.5 | hisJ, hisQ, hisM, hisP |
ggtgcattgaAATGCATACTTAAGCATTtttaatgaaa
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2426912 | 2426929 | [BPP], [GEA], [SM] | [11] | |
ArgR-L-arginine | repressor | hisJp | Sigma70 | -62.5 | -111.5 | hisJ, hisQ, hisM, hisP |
aagcatttttAATGAAAAATAATACGTCtaacggggcg
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2426891 | 2426908 | [AIBSCS], [BPP], [GEA], [SM] | [1], [5], [11] | |
ArgR-L-arginine | repressor | lysOp | Sigma70 | -55.5 | -93.5 | lysO |
tactgctcctTATGCATAACATTTCCTTttaattgcaa
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914942 | 914959 | [BPP], [GEA], [SM] | [16] | |
ArgR-L-arginine | repressor | lysOp | Sigma70 | -34.5 | -72.5 | lysO |
tttccttttaATTGCAACTTTACTCGTCcttccgcttt
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914921 | 914938 | [BPP], [GEA], [SM] | [16] | |
ArgR-L-arginine | repressor | metYp2 | Sigma70 | -201.5 | -287.5 | metY, rimP, nusA, infB, rbfA, truB, rpsO, pnp |
ttccgctctcACTGAATTTTTATGCAAAataaatgagt
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3318568 | 3318585 | [AIBSCS], [BPP], [GEA], [HIBSCS] | [1], [4], [5], [10] | |
ArgR-L-arginine | repressor | metYp2 | Sigma70 | -180.5 | -266.5 | metY, rimP, nusA, infB, rbfA, truB, rpsO, pnp |
atgcaaaataAATGAGTTTTCATTTAATcatcttttat
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3318547 | 3318564 | [AIBSCS], [BPP], [GEA], [HIBSCS] | [1], [4], [5], [10] | |
ArgR-L-arginine | repressor | metYp2 | Sigma70 | -61.5 | -147.5 | metY, rimP, nusA, infB, rbfA, truB, rpsO, pnp |
atgaaagtgaACTGGATATTCATTCACAtgattagcaa
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3318428 | 3318445 | [AIBSCS], [BPP], [GEA], [HIBSCS] | [1], [4], [5], [10] |
Alignment and PSSM for ArgR TFBSs | ![]() |
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Position weight matrix (PWM). |
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A 19 8 5 3 19 23 3 11 8 5 4 27 6 1 0 28 10 16 C 2 6 5 3 4 3 1 0 2 0 8 0 2 3 28 0 5 0 G 2 8 1 23 3 1 1 1 0 1 0 1 0 14 0 0 3 1 T 6 7 18 0 3 2 24 17 19 23 17 1 21 11 1 1 11 12 |
Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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