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Synonyms: FadR-an acyl-CoA, FadR |
Summary:
FadR, Fatty acid degradation Regulon [16], is a multifunctional dual regulator [17] that exerts negative control over the fatty acid degradative regulon [18, 19] and acetate metabolism [20], whereas it is responsible for maximal expression of unsaturated fatty acid biosynthesis [21]. FadR coordinately regulates fatty acid biosynthesis and fatty acid degradation at the level of transcription [22]. In this way, FadR functions as a switch between fatty acid β-oxidation and fatty acid biosynthesis [23]. FadR is a global regulator of lipid metabolism and a global regulator of fatty acid (FA) metabolism, acting both as a repressor of catabolism and an activator of anabolism, two directly opposing pathways, degradation and synthesis [2]. Read more > |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Evolutionary Family: | GntR | ||||||||||||||||||
Sensing class: | Using internal synthesized signals | ||||||||||||||||||
Connectivity class: | Local Regulator | ||||||||||||||||||
Gene name: | fadR | ||||||||||||||||||
Genome position: | 1234938-1235657 | ||||||||||||||||||
Length: | 720 bp / 239 aa | ||||||||||||||||||
Operon name: | fadR | ||||||||||||||||||
TU(s) encoding the TF: |
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Regulon |
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Regulated gene(s) | accA, accB, accC, accD, fabA, fabB, fabD, fabG, fabH, fabI, fadA, fadB, fadD, fadE, fadH, fadI, fadJ, fadL, fadM, fadR, iclR, sroD, uspA | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
fatty acids and phosphatidic acid (10)
fatty acids (10)
Transcription related (2)
repressor (2)
operon (2)
Read more >
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Regulated operon(s) | accA, accBC, accD, fabA, fabB, fabI, fadBA, fadD-sroD, fadE, fadH, fadIJ, fadL, fadM, fadR, iclR, uspA, yceD-rpmF-plsX-fabHDG-acpP-fabF | ||||||
First gene in the operon(s) | accA, accB, accD, fabA, fabB, fabH, fabI, fadB, fadD, fadE, fadH, fadI, fadL, fadM, fadR, iclR, uspA | ||||||
Simple and complex regulons | ArcA,CRP,FadR,HipB ArcA,CRP,FadR,OmpR,PhoP,Rob,ppGpp ArcA,CRP,FadR,ppGpp ArcA,FadR ArcA,FadR,Fis,Rob Read more > | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Transcription factor regulation |
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Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
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FadR | activator | accAp2 | nd | -38.0 | -333.0 | accA |
atcgtcagcgGACAGGTCAGCTTTGATgacttcagcg
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208280 | 208296 | [GEA], [AIBSCS], [BPP] | [2] | |
FadR | activator | accBp2 | nd | -49.0 | -313.0 | accB, accC |
tgattatcttCCCTGATAAGACCAGTAtttagctgcc
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3405115 | 3405131 | [GEA], [AIBSCS], [BPP] | [2] | |
FadR | activator | accDp | Sigma70 | -49.0 | -138.0 | accD |
aaaagtaactCCGCGGTTCGACCACTTttttatccaa
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2434056 | 2434072 | [GEA], [AIBSCS], [BPP] | [2] | |
FadR | activator | fabAp | Sigma70 | -38.0 | -66.0 | fabA |
gtttattccgAACTGATCGGACTTGTTcagcgtacac
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1016528 | 1016544 | [GEA], [APIORCISFBSCS], [BCE] | [3] | |
FadR | activator | fabBp | Sigma70 | -39.0 | -75.0 | fabB |
tctattaaatGGCTGATCGGACTTGTTcggcgtacaa
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2441672 | 2441688 | [GEA], [APIORCISFBSCS], [BPP] | [3], [4] | |
FadR | activator | fabHp | nd | -38.0 | -281.0 | fabH, fabD, fabG |
attcagtcacCTCAACCCCGACCAGTAtaacggcgcc
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1148470 | 1148486 | [GEA], [APIORCISFBSCS], [BPP], [SM] | [5], [6] | |
FadR | activator | fabIp | nd | -48.0 | -130.0 | fabI |
ccgcagcctgCTCCGGTCGGACCTGGCaactatagct
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1351161 | 1351177 | [GEA], [AIBSCS], [BPP] | [2] | |
FadR | repressor | fadBp | Sigma70 | 9.0 | -34.0 | fadB, fadA |
acttcgactcATCTGGTACGACCAGATcaccttgcgg
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4030997 | 4031013 | [APIORCISFBSCS], [BCE] | ||
FadR | repressor | fadDp | Sigma70 | -106.0 | -167.0 | fadD, sroD |
aagaaacagcGGCTGGTCCGCTGTTTCtgcattctta
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1889905 | 1889921 | [BPP] | [7], [8] | |
FadR | repressor | fadDp | Sigma70 | -20.0 | -81.0 | fadD, sroD |
gtaattatcaAGCTGGTATGATGAGTTaatattatgt
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1889819 | 1889835 | [BPP] | [7], [8] | |
FadR | repressor | fadEp | nd | 74.0 | -30.0 | fadE |
atatcatcacAAGTGGTCAGACCTCCTacaagtaagg
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243325 | 243341 | [GEA], [APIORCISFBSCS], [BPP] | [9] | |
FadR | repressor | fadHp | nd | 4.0 | -38.0 | fadH |
gctaaattagAACTCATCCGACCACATaacaattatt
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3231619 | 3231635 | [GEA], [APIORCISFBSCS], [BPP] | [10], [11] | |
FadR | repressor | fadIp | Sigma70 | 8.0 | -35.0 | fadI, fadJ |
taagactatgATCAGGTCAGACCACTTtatttatttt
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2460496 | 2460512 | [GEA], [APIORCISFBSCS], [BPP] | [12] | |
FadR | repressor | fadLp | Sigma38 | -17.0 | -118.0 | fadL |
gcaacattccAGCTGGTCCGACCTATActctcgccac
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2461180 | 2461196 | [GEA], [APIORCISFBSCS], [BCE], [BPP] | [8] | |
FadR | repressor | fadLp | Sigma38 | 9.0 | -93.0 | fadL |
tactctcgccACTGGTCTGATTTCTAAgatgtacctc
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2461205 | 2461221 | [APIORCISFBSCS], [BCE], [BPP] | [8] | |
FadR | repressor | fadMp1 | Sigma24 | 2.0 | -41.0 | fadM |
aagaggtcatACCAGTTATGACCTCTGtacttataac
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464353 | 464369 | [APIORCISFBSCS] | [13] | |
FadR-an acyl-CoA | activator | fadRp1 | Sigma70 | -10.0 | -43.0 | fadR |
gtagttagccCTCTGGTATGATGAGTCCaactttgttt
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1234887 | 1234904 | [AIBSCS] | [6] | |
FadR | activator | iclRp | nd | -54.0 | -78.0 | iclR |
gttcaacattAACTCATCGGATCAGTTcagtaactat
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4223698 | 4223714 | [GEA], [BPP], [SM] | [14] | |
FadR | repressor | uspAp1 | Sigma70 | 5.0 | -124.0 | uspA |
ctataaggtaAGGATGGTCTTAACACTgaatctttac
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3639979 | 3639995 | [GEA], [APIORCISFBSCS], [BCE], [BPP] | [15] | |
FadR | repressor | uspAp1 | Sigma70 | 97.0 | -32.0 | uspA |
agaaacgctaGCTGGCCAGTCATCGACaactttatgg
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3640071 | 3640087 | [GEA], [APIORCISFBSCS], [BCE], [BPP] | [15] |
Alignment and PSSM for FadR TFBSs | ![]() |
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Aligned TFBS of FadR |
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Sequence | |
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GATCAGGTCAGACCACTTTA | |
CCTCTGGTATGATGAGTCCA | |
CATCTGGTACGACCAGATCA | |
CAGCTGGTCCGACCTATACT | |
TATGTGGTCGGATGAGTTCT | |
GAACTGATCGGACTTGTTCA | |
GAACTGATCCGATGAGTTAA | |
TCCCTGATAAGACCAGTATT | |
TGGCTGATCGGACTTGTTCG | |
GCTCCGGTCGGACCTGGCAA | |
TAGGAGGTCTGACCACTTGT | |
AAGCTGGTATGATGAGTTAA | |
CCACTGGTCTGATTTCTAAG | |
TCCGCGGTTCGACCACTTTT | |
CATCAAAGCTGACCTGTCCG | |
TACCAGTTATGACCTCTGTA | |
CCTCAACCCCGACCAGTATA | |
CGGCTGGTCCGCTGTTTCTG | |
TAGCTGGCCAGTCATCGACA | |
TCAGTGTTAAGACCATCCTT |
Position weight matrix (PWM). FadR matrix-quality result |
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A 1 11 4 0 5 2 5 0 6 4 0 18 0 1 11 1 1 5 4 10 C 7 7 3 16 2 0 1 2 13 6 0 1 14 11 0 6 1 5 8 0 G 4 2 6 4 0 18 12 1 0 4 20 0 0 5 0 11 2 1 1 4 T 8 0 7 0 13 0 2 17 1 6 0 1 6 3 9 2 16 9 7 6 |
Consensus |
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; consensus.strict cagCtGGTCcGACcagttca ; consensus.strict.rc TGAACTGGTCGGACCAGCTG ; consensus.IUPAC ymkCtGGTMyGAYswstyyw ; consensus.IUPAC.rc WRRASWSRTCRKACCAGMKR ; consensus.regexp [ct][ac][gt]CtGGT[AC][ct]GA[CT][cg][at][cg]t[ct][ct][at] ; consensus.regexp.rc [AT][AG][AG]A[CG][AT][CG][AG]TC[AG][GT]ACCAG[AC][GT][AG] |
Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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