![]() ![]() |
Synonyms: NagC, NagC-N-acetyl-D-glucosamine 6-phosphate |
Summary:
The NagC, "N-acetylglucosamine," transcriptional dual regulator participates in regulating the phosphotransferase system (PTS) [16] Its function is to coordinate the biosynthesis of the amino sugars, D-glucosamine (GlcN) and N-acetylglucosamine (GlcNAc) with their catabolism [1, 2, 12, 17]. The specific inducer for NagC is GlcNAc-6-P, the product of GlcNAc transport by the PTS [1, 17] NagC is displaced from its DNA targets by interacting with GlcNAc-6-P [1] Mutation in the first two amino acids of the recognition helix of the DNA-binding motif causes GlcNAc6P to act with NagC as a corepressor instead of as an inducer [11]. Proline at the first position of this helix seems to contribute to the distinction between the NagC binding sites and suboptimal sites [11]. Based on the structure of |FRAME: PD01896|, models for the three-dimensional structure of NagC and for the binding of GlcNAc-6-P were developed [16] The Nag regulon consists of two divergent operons, nagE and nagBACD. Read more > |
Transcription factor | ![]() ![]() |
||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TF conformation(s): |
|
||||||||||||||||||
Evolutionary Family: | MarR | ||||||||||||||||||
Sensing class: | External sensing using transported metabolites | ||||||||||||||||||
Connectivity class: | Local Regulator | ||||||||||||||||||
Gene name: | nagC | ||||||||||||||||||
Genome position: | 700374-701594 | ||||||||||||||||||
Length: | 1221 bp / 406 aa | ||||||||||||||||||
Operon name: | nagBAC-umpH | ||||||||||||||||||
TU(s) encoding the TF: |
|
Regulon |
![]() ![]() |
||||||
---|---|---|---|---|---|---|---|
Regulated gene(s) | chbA, chbB, chbC, chbF, chbG, chbR, chiP, chiQ, chiZ, creA, creB, creC, creD, crr, dinI, feoA, feoB, feoC, fimB, galP, glmS, glmU, manX, manY, manZ, nagA, nagB, nagC, nagE, nanC, nanM, nanS, ptsH, ptsI, umpH, ydeM, ydeN, ydeP | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
carbon compounds (14)
membrane (9)
Phosphotransferase Systems (PEP-dependent PTS) (8)
amino sugar conversions (5)
operon (4)
Read more >
|
||||||
Regulated operon(s) | chbBCARFG, chiZPQ, creABCD, dinI, feoABC, fimB, galP, glmUS, manXYZ, nagBAC-umpH, nagE, nanCMS, ptsHI-crr, ydeNM, ydeP | ||||||
First gene in the operon(s) | chbB, chiZ, creA, dinI, feoA, fimB, galP, glmU, manX, nagB, nagE, nanC, ptsH, ydeN, ydeP | ||||||
Simple and complex regulons | AraC,GadX,NagC BasR,DksA,DksA-ppGpp,H-NS,IHF,NagC,NanR,ppGpp CRP,ChbR,NagC CRP,Cra,Mlc,NagC CRP,GalR,GalS,NagC Read more > | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Transcription factor regulation |
![]() |
---|
Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
NagC | repressor | chbBp | nd | -112.0 | -219.0 | chbB, chbC, chbA, chbR, chbF, chbG |
ggcctgagttCTTAATTATCTTCGCGAATTATTtgcccgaaat
|
1821827 | 1821849 | [GEA], [AIBSCS], [APIORCISFBSCS], [BPP], [SM] | [2] | |
NagC | repressor | chbBp | nd | 1.0 | -107.0 | chbB, chbC, chbA, chbR, chbF, chbG |
tctataccgtATACTCCTTTCAGCCACAAAAAAagtcatgttg
|
1821715 | 1821737 | [GEA], [APIORCISFBSCS], [BPP] | [2] | |
NagC | repressor | chiPp | nd | -244.0 | -244.0 | chiZ, chiP, chiQ |
cggcgtttttTCTGCTTTTCTTCGCGAATTAATTCcgcttcgcaa
|
707980 | 708004 | [GEA], [BPP] | [3] | |
NagC | repressor | chiPp | nd | -22.0 | -22.0 | chiZ, chiP, chiQ |
gaaagagattGATAATTCGCGTCGCGAAAAATAgtctgttcct
|
708203 | 708225 | [GEA], [AIBSCS], [BPP] | [3] | |
NagC | repressor | creAp | Sigma70 | 2.0 | -43.0 | creA, creB, creC, creD |
taatcaatatGTTATTTACCGTGACGAACTAATtgctcgtgta
|
4635467 | 4635489 | [AIBSCS] | ||
NagC | repressor | dinIp | Sigma70 | -14.0 | -36.0 | dinI |
ttgtcattagGTTATTTTACCTGTATAAATAACcagtatattc
|
1121512 | 1121534 | [AIBSCS] | ||
NagC | unknown | feoAp | Sigma70 | -128.0 | -234.0 | feoA, feoB, feoC |
agccagtccgGGTAATTCACTATTCGAATTATAttttcgctgc
|
3539918 | 3539940 | [AIBSCS] | ||
NagC | activator | fimBp2 | nd | -674.0 | -964.0 | fimB |
aaaccagattTGCAATTCGTGTCACAAAATATGtcgatctttt
|
4539982 | 4540004 | [GEA], [AIBSCS], [APIORCISFBSCS], [BPP], [SM] | [4], [5], [6] | |
NagC | activator | fimBp2 | nd | -462.0 | -752.0 | fimB |
tcaggctgagCATAATTCTCATCATGAAATATGtttcctggtt
|
4540194 | 4540216 | [AIBSCS], [APIORCISFBSCS], [BPP], [SM] | [5] | |
NagC | repressor | galPp | Sigma70 | 2.0 | -28.0 | galP |
actcacctatCTTAATTCACAATAAAAAATAACcatattggag
|
3088245 | 3088267 | [AIBSCS], [BPP], [SM] | [7] | |
NagC | activator | glmUp1 | Sigma70 | -199.0 | -222.0 | glmU, glmS |
ctgttttcctGTTTATTCATTGATCGAAATAAGagcaaaaaca
|
3915411 | 3915433 | [APIORCISFBSCS], [BPP], [SM] | [8] | |
NagC | activator | glmUp1 | Sigma70 | -46.0 | -69.0 | glmU, glmS |
ttatcctctgTCCATTTCACGATGAAAAAAATGtagttttttc
|
3915258 | 3915280 | [APIORCISFBSCS], [BPP], [SM] | [8] | |
NagC | repressor | glmUp2 | Sigma70 | -96.0 | -222.0 | glmU, glmS |
ctgttttcctGTTTATTCATTGATCGAAATAAGagcaaaaaca
|
3915411 | 3915433 | [APIORCISFBSCS], [BPP], [SM] | [8] | |
NagC | repressor | glmUp2 | Sigma70 | 58.0 | -69.0 | glmU, glmS |
ttatcctctgTCCATTTCACGATGAAAAAAATGtagttttttc
|
3915258 | 3915280 | [APIORCISFBSCS], [BPP], [SM] | [8] | |
NagC | repressor | manXp | Sigma70 | -80.0 | -195.0 | manX, manY, manZ |
atgtgacaagGATATTTTACCTTTCGAAATTTCtgctaatcga
|
1901842 | 1901864 | [GEA], [AIBSCS], [APIORCISFBSCS], [BCE] | [9], [10] | |
NagC | repressor | manXp | Sigma70 | 4.0 | -112.0 | manX, manY, manZ |
cgatatctaaAATAAATCGCGAAACGCAGGGGTttttggttgt
|
1901925 | 1901947 | [GEA], [BCE] | [9], [10] | |
NagC | repressor | nagBp | Sigma70 | -101.0 | -198.0 | nagB, nagA, nagC, umpH |
tgtgtgaaaaTTTAATTCGTATCGCAAATTAAAcgcgtgtctt
|
703798 | 703820 | [GEA], [BPP], [SM] | [10], [11], [12], [13], [14] | |
NagC | repressor | nagBp | Sigma70 | -7.0 | -104.0 | nagB, nagA, nagC, umpH |
aaccagaaaaCTTATTTTATCATTCAAAAAATCaggtcggatt
|
703704 | 703726 | [GEA], [BPP], [SM] | [10], [11], [12], [13], [14] | |
NagC | repressor | nagEp | Sigma70 | -125.0 | -229.0 | nagE |
aatccgacctGATTTTTTGAATGATAAAATAAGttttctggtt
|
703704 | 703726 | [GEA], [BPP], [SM] | [11], [12], [13], [14] | |
NagC | repressor | nagEp | Sigma70 | -31.0 | -135.0 | nagE |
aagacacgcgTTTAATTTGCGATACGAATTAAAttttcacaca
|
703798 | 703820 | [GEA], [BPP], [SM] | [11], [12], [13], [14] | |
NagC | repressor | nanCp | nd | -277.0 | -704.0 | nanC, nanM, nanS |
aaccaggaaaCATATTTCATGATGAGAATTATGctcagcctga
|
4540194 | 4540216 | [AIBSCS], [APIORCISFBSCS], [BPP], [SM] | ||
NagC | repressor | nanCp | nd | -65.0 | -492.0 | nanC, nanM, nanS |
aaaagatcgaCATATTTTGTGACACGAATTGCAaatctggttt
|
4539982 | 4540004 | [GEA], [AIBSCS], [APIORCISFBSCS], [BPP], [SM] | [4] | |
NagC | repressor | ptsHp | Sigma32 | 13.0 | -251.0 | ptsH, ptsI, crr |
aaccagactaATTATTTTGATGCGCGAAATTAAtcgttacagg
|
2533502 | 2533524 | [AIBSCS], [APIORCISFBSCS], [BPP] | [15] | |
NagC | repressor | ptsHp3 | nd | 7.0 | -251.0 | ptsH, ptsI, crr |
aaccagactaATTATTTTGATGCGCGAAATTAAtcgttacagg
|
2533502 | 2533524 | [AIBSCS], [APIORCISFBSCS], [BPP] | [15] | |
NagC | repressor | ptsHp4 | Sigma70 | 13.0 | -251.0 | ptsH, ptsI, crr |
aaccagactaATTATTTTGATGCGCGAAATTAAtcgttacagg
|
2533502 | 2533524 | [AIBSCS], [APIORCISFBSCS], [BPP] | [15] | |
NagC | repressor | ptsHp5 | Sigma32 | 16.0 | -251.0 | ptsH, ptsI, crr |
aaccagactaATTATTTTGATGCGCGAAATTAAtcgttacagg
|
2533502 | 2533524 | [APIORCISFBSCS], [BPP] | ||
NagC | repressor | ydeNp | Sigma70 | -140.0 | -170.0 | ydeN, ydeM |
caataaattaGTTGTTTATCGGCGAGAAATTACttaatagaac
|
1582683 | 1582705 | [AIBSCS] | ||
NagC | repressor | ydeNp | Sigma70 | -16.0 | -46.0 | ydeN, ydeM |
cttacatccaCTTATTTCTCTTCGTAAAATTACtttggaatta
|
1582559 | 1582581 | [AIBSCS] | ||
NagC | repressor | ydePp | Sigma70 | -28.0 | -206.0 | ydeP |
aagccagagtCTTATTTTTTATATTGAAAAATAtgttaattta
|
1586681 | 1586703 | [AIBSCS] |
Alignment and PSSM for NagC TFBSs | ![]() |
---|
Aligned TFBS of NagC |
---|
Sequence | |
---|---|
AAATAATTCGCGAAGATAATTAAGA | |
ACATATTTCATGATGAGAATTATGC | |
AGTAATTTTACGAAGAGAAATAAGT | |
CTATTTTTCGCGACGCGAATTATCA | |
AATTAATTCGCGAAGAAAAGCAGAA | |
ATTAATTTCGCGCATCAAAATAATT | |
ATTTAATTCGTATCGCAAATTAAAC | |
TCTTAATTCACAATAAAAAATAACC | |
AATTAGTTCGTCACGGTAAATAACA | |
AGAAATTTCGAAAGGTAAAATATCC | |
ATATAATTCGAATAGTGAATTACCC | |
ACATATTTTGTGACACGAATTGCAA | |
ACTTATTTTATCATTCAAAAAATCA | |
AGTAATTTCTCGCCGATAAACAACT | |
ATATTTTTCAATATAAAAAATAAGA | |
TCTTATTTCGATCAATGAATAAACA | |
GGTTATTTTACCTGTATAAATAACC | |
GTCCATTTCACGATGAAAAAAATGT | |
ACTTTTTTTGTGGCTGAAAGGAGTA | |
AAATAAATCGCGAAACGCAGGGGTT |
Position weight matrix (PWM). NagC matrix-quality result |
---|
A 15 4 8 4 17 6 1 0 0 7 4 4 13 7 5 9 9 19 20 10 3 18 10 3 9 C 1 6 1 1 0 0 0 0 15 0 10 3 3 6 0 6 0 1 0 0 2 0 2 9 6 G 2 4 0 0 0 1 0 0 0 12 0 11 1 2 11 2 7 0 0 3 2 2 3 5 0 T 2 6 11 15 3 13 19 20 5 1 6 2 3 5 4 3 4 0 0 7 13 0 5 3 5 |
Consensus |
---|
; consensus.strict acttAtTTCGcgacgagAAatAaca ; consensus.strict.rc TGTTATTTCTCGTCGCGAAATAAGT ; consensus.IUPAC aywtAwTTCRygamgmrAAwtAasm ; consensus.IUPAC.rc KSTTAWTTYKCKTCRYGAAWTAWRT ; consensus.regexp a[ct][at]tA[at]TTC[AG][ct]ga[ac]g[ac][ag]AA[at]tAa[cg][ac] ; consensus.regexp.rc [GT][CG]TTA[AT]TT[CT][GT]C[GT]TC[AG][CT]GAA[AT]TA[AT][AG]T |
Evolutionary conservation of regulatory elements | ![]() |
---|
Reference(s) |
![]() |
---|---|