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Synonyms: NorR |
Summary:
NorR, "NO reduction and detoxification Regulator," is one of several regulatory proteins, such as Fur, SoxR, and OxyR, that are involved in the response to reactive nitrogen species. Under anaerobic and microaerobic conditions it activates transcription of the norVW operon, encoding a nitric oxide (NO)-reducing flavorubredoxin that detoxifies NO [4, 5, 6, 8, 9]. A norR mutant is completely defective with respect to anaerobic NO detoxification [5] and is sensitive to reactive nitrogen intermediates generated from nitroprusside. The norR gene is transcribed divergently from norVW and autoregulated [3]. It is activated in the absence of oxygen and by nitrite under anaerobic conditions [10]. NorR is a σ54-dependent transcriptional activator [11]. Read more > |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Evolutionary Family: | EBP | ||||||||||||
Connectivity class: | Local Regulator | ||||||||||||
Gene name: | norR | ||||||||||||
Genome position: | 2830775-2832289 | ||||||||||||
Length: | 1515 bp / 504 aa | ||||||||||||
Operon name: | norR | ||||||||||||
TU(s) encoding the TF: |
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Regulon |
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Regulated gene(s) | norR, norV, norW | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
detoxification (2)
electron carriers (2)
Transcription related (1)
activator (1)
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Regulated operon(s) | norR, norVW | ||||||
First gene in the operon(s) | norR, norV | ||||||
Simple and complex regulons | FNR,IHF,NarL,NarP,NorR NorR,NsrR | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Transcription factor regulation |
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Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
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NorR | repressor | norRp | nd | -45.0 | -63.0 | norR |
attaatgagtAGTCAAAATGACTatcaatcaaa
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2832346 | 2832358 | [GEA], [AIBSCS], [BPP] | [1], [2], [3] | |
NorR | repressor | norRp | nd | -21.0 | -39.0 | norR |
tcaatcaaatGGTCGATATGACAatatctatag
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2832322 | 2832334 | [GEA], [AIBSCS], [BPP] | [1], [3] | |
NorR | repressor | norRp | nd | 1.0 | -18.0 | norR |
caatatctatAGTCAAATTGACAgtgaggcaaa
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2832301 | 2832313 | [GEA], [AIBSCS], [BPP] | [1], [3] | |
NorR | activator | norVp | Sigma54 | -132.0 | -169.0 | norV, norW |
tttgcctcacTGTCAATTTGACTatagatattg
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2832301 | 2832313 | [GEA], [AIBSCS], [BPP] | [1], [2], [3], [4], [5], [6] | |
NorR | activator | norVp | Sigma54 | -111.0 | -148.0 | norV, norW |
ctatagatatTGTCATATCGACCatttgattga
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2832322 | 2832334 | [GEA], [AIBSCS], [BPP] | [1], [2], [3], [4], [5], [6] | |
NorR | activator | norVp | Sigma54 | -87.0 | -124.0 | norV, norW |
tttgattgatAGTCATTTTGACTactcattaat
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2832346 | 2832358 | [GEA], [AIBSCS], [BPP] | [1], [2], [3], [4], [5], [6], [7] |
Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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