RegulonDB RegulonDB 10.9:Regulon Page

MngR DNA-binding transcriptional repressor

Synonyms: MngR
According to microarray analysis, the "mannosyl-d-glycerate regulator," MngR, regulates only two genes, mngA and mngB, involved in 2-O-α-mannosyl-D-glycerate utilization [4]. This regulator also autoregulates its own synthesis [3]. Previously, MngR, also called FarR, for fatty acyl-responsive regulator, had been proposed to regulate genes involved in the citric acid cycle in response to fatty acids, which release MngR from its DNA-binding site [3]. However, when it was found that this protein only regulates two genes, the suggestion was rejected and it was proposed that probably high concentrations of fatty acids could degrade the protein instead of it binding to the regulator [4]. MngR belongs to the GntR family of transcriptional regulators and has a helix-turn-helix motif in the N-terminal domain and a UbiC transcription regulator-associated domain that is predicted to be a sensor for small molecules.
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Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
MngR Functional   [APPHINH], [HIFS], [IEP] [1], [2], [3], [4]
Evolutionary Family: GntR
Sensing class: Using internal synthesized signals
Connectivity class: Local Regulator
Gene name: mngR
  Genome position: 765153-765875
  Length: 723 bp / 240 aa
Operon name: mngR
TU(s) encoding the TF:
Transcription unit        Promoter

Regulated gene(s) mngA, mngB, mngR
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
carbon compounds (2)
posttranslational modification (1)
Phosphotransferase Systems (PEP-dependent PTS) (1)
temperature extremes (1)
membrane (1)
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Regulated operon(s) mngAB, mngR
First gene in the operon(s) mngA, mngR
Simple and complex regulons MngR
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)

Transcription factor regulation    

Transcription factor binding sites (TFBSs) arrangements

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence
LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  MngR repressor mngAp Sigma32 90.5 -83.5 mngA, mngB
765890 765911 [APIORCISFBSCS], [BPP], [APIORCISFBSCS], [BPP] [3], [4]
  MngR repressor mngAp Sigma32 134.5 -39.5 mngA, mngB
765934 765955 [APIORCISFBSCS], [BPP], [APIORCISFBSCS], [BPP], [GEA] [3], [4]
  MngR repressor mngRp Sigma70 -18.5 -69.5 mngR
765934 765955 [APIORCISFBSCS], [BPP], [GEA] [4]
  MngR repressor mngRp Sigma70 26.5 -25.5 mngR
765890 765911 [APIORCISFBSCS], [BPP] [4]

Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation