The Carbohydrate diacid regulator, CdaR, or sugar diacid regulator, SdaR, regulates genes involved in the uptake and metabolism of galactarate and glucarate, and it is also autoregulated |CITS: |.
SdaR responds to d-galactarate and d-glucarate, and even better to d-glycerate to activate the genes it regulates |CITS: |. In addition, it was found that 2-O-α-mannosyl-d-glycerate (MG) can induce the SdaR regulon |CITS:|. MG has been recognized as a protective osmolyte in hyperthermophylic prokaryotes and as a carbon source for Escherichia coli |CITS:|.
This protein has a helix-turn-helix motif for DNA binding in the C-terminal domain |CITS: |.
The exact position and sequence that SdaR binds to in DNA have not been yet determined.
|Sensing class:||Using internal synthesized signals|
|Connectivity class:||Local Regulator|
|Length:||1158 bp / 385 aa|
|TU(s) encoding the TF:||
|Regulated gene(s)||cdaR, garD, garK, garL, garP, garR, gudD, gudP, gudX, rnpB|
|Multifun term(s) of regulated gene(s)||
MultiFun Term (List of genes associated to the multifun term)
carbon compounds (8)
garD, garK, garL, garP, garR, gudD, gudP, gudX
Porters (Uni-, Sym- and Antiporters) (2)
Transcription related (1)
cdaRRead more >
|Regulated operon(s)||cdaR, garD, garPLRK-rnpB, gudPXD|
|First gene in the operon(s)||cdaR, garD, garP, gudP|
|Simple and complex regulons|
|Simple and complex regulatory phrases||Regulatory phrase (List of promoters regulated by the phrase)|
|Functional conformation||Function||Promoter||Sigma factor||Central Rel-Pos||Distance to first Gene||Genes||Sequence||LeftPos||RightPos||Evidence (Confirmed, Strong, Weak)||References|
|CdaR||activator||garPp||Sigma70||nd||nd||garP, garL, garR, garK, rnpB||nd||nd||[GEA]||, |
|CdaR||activator||gudPp||nd||nd||nd||gudP, gudX, gudD||nd||nd||[GEA]||, |
|Evolutionary conservation of regulatory elements|
 Monterrubio R., Baldoma L., Obradors N., Aguilar J., Badia J., 2000, A common regulator for the operons encoding the enzymes involved in D-galactarate, D-glucarate, and D-glycerate utilization in Escherichia coli., J Bacteriol. 182(9):2672-4
 Sampaio MM., Chevance F., Dippel R., Eppler T., Schlegel A., Boos W., Lu YJ., Rock CO., 2004, Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor., J Biol Chem. 279(7):5537-48