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CdaR DNA-binding transcriptional activator

Synonyms: CdaR
The Carbohydrate diacid regulator, CdaR, or sugar diacid regulator, SdaR, regulates genes involved in the uptake and metabolism of galactarate and glucarate, and it is also autoregulated |CITS: [10762278]|.
SdaR responds to d-galactarate and d-glucarate, and even better to d-glycerate to activate the genes it regulates |CITS: [10762278]|. In addition, it was found that 2-O-α-mannosyl-d-glycerate (MG) can induce the SdaR regulon |CITS:[14645248]|. MG has been recognized as a protective osmolyte in hyperthermophylic prokaryotes and as a carbon source for Escherichia coli |CITS:[14645248]|.
This protein has a helix-turn-helix motif for DNA binding in the C-terminal domain |CITS: [10762278]|.
The exact position and sequence that SdaR binds to in DNA have not been yet determined.

Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
CdaR     nd nd
Evolutionary Family: Cdar
Sensing class: Using internal synthesized signals
Connectivity class: Local Regulator
Gene name: cdaR
  Genome position: 182463-183620
  Length: 1158 bp / 385 aa
Operon name: cdaR
TU(s) encoding the TF:
Transcription unit        Promoter

Regulated gene(s) cdaR, garD, garK, garL, garP, garR, gudD, gudP, gudX, rnpB
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
carbon compounds (8)
Porters (Uni-, Sym- and Antiporters) (2)
membrane (2)
Transcription related (1)
activator (1)
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Regulated operon(s) cdaR, garD, garPLRK-rnpB, gudPXD
First gene in the operon(s) cdaR, garD, garP, gudP
Simple and complex regulons CdaR
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)

Transcription factor binding sites (TFBSs) arrangements       

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  CdaR activator cdaRp nd nd nd cdaR nd nd [GEA] [1], [2]
  CdaR activator garDp nd nd nd garD nd nd [GEA] [1], [2]
  CdaR activator garPp Sigma70 nd nd garP, garL, garR, garK, rnpB nd nd [GEA] [1], [2]
  CdaR activator gudPp nd nd nd gudP, gudX, gudD nd nd [GEA] [1], [2]

Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation


 [GEA] Gene expression analysis


 [1] Monterrubio R., Baldoma L., Obradors N., Aguilar J., Badia J., 2000, A common regulator for the operons encoding the enzymes involved in D-galactarate, D-glucarate, and D-glycerate utilization in Escherichia coli., J Bacteriol. 182(9):2672-4

 [2] Sampaio MM., Chevance F., Dippel R., Eppler T., Schlegel A., Boos W., Lu YJ., Rock CO., 2004, Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor., J Biol Chem. 279(7):5537-48