RegulonDB RegulonDB 11.1:Regulon Page

CdaR DNA-binding transcriptional activator

Synonyms: CdaR
The "Carbohydrate diacid regulator," CdaR, or "sugar diacid regulator," SdaR, regulates genes involved in the uptake and metabolism of galactarate and glucarate, and it is also autoregulated [1]. SdaR responds to d-galactarate and d-glucarate, and even better to d-glycerate to activate the genes it regulates [1]. In addition, it was found that 2-O-α-mannosyl-d-glycerate (MG) can induce the SdaR regulon [2]. MG has been recognized as a protective osmolyte in hyperthermophylic prokaryotes and as a carbon source for Escherichia coli [2]. This protein has a helix-turn-helix motif for DNA binding in the C-terminal domain [1]. The exact position and sequence that SdaR binds to in DNA have not been yet determined. It has been observed that cdaR contains a single nucleotide mutation in cells induced for chlorhexidine (CHX) resistance, and its expression is repressed in these altered cells [3]. Read more >

Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) References
CdaR Functional   nd nd nd
Evolutionary Family: Cdar
TFBs symmetry: inverted-repeat
Sensing class: Using internal synthesized signals
Connectivity class: Local Regulator
Gene name: cdaR
  Genome position: 182463-183620
  Length: 1158 bp / 385 aa
Operon name: cdaR
TU(s) encoding the TF:
Transcription unit        Promoter

Regulated gene(s) cdaR, garD, garK, garL, garP, garR, gudD, gudP, gudX, rnpB
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
carbon compounds (8)
Porters (Uni-, Sym- and Antiporters) (2)
membrane (2)
Transcription related (1)
activator (1)
Read more >
Regulated operon(s) cdaR, garD, garPLRK-rnpB, gudPXD
First gene in the operon(s) cdaR, garD, garP, gudP
Simple and complex regulons CdaR
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)

Transcription factor regulation    

Transcription factor binding sites (TFBSs) arrangements

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) References
  CdaR activator cdaRp nd nd nd cdaR nd nd [EXP-IEP-GENE-EXPRESSION-ANALYSIS] W [1], [2]
  CdaR activator garDp nd nd nd garD nd nd [EXP-IEP-GENE-EXPRESSION-ANALYSIS] W [1], [2]
  CdaR activator garPp Sigma70 nd nd garP, garL, garR, garK, rnpB nd nd [EXP-IEP-GENE-EXPRESSION-ANALYSIS] W [1], [2]
  CdaR activator gudPp nd nd nd gudP, gudX, gudD nd nd [EXP-IEP-GENE-EXPRESSION-ANALYSIS] W [1], [2]

Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation