RegulonDB RegulonDB 11.1:Regulon Page

UidR DNA-binding transcriptional repressor

Synonyms: UidR
The "β-d-glucuronides repressor," UidR, is a transcriptional repressor. UidR negatively regulates its own synthesis and represses transcription of the uid operon, which is involved in transport and degradation of β-glucosides [1, 2, 4, 5, 6]. This regulator is involved in the degradation of sugar acids and is subject to catabolic repression in the presence of glucose and at low levels of cyclic AMP. Although little is known about the regulating mechanism of UidR, it has been shown to act as a repressor, binding to a putative inverted repeat sequence in a cooperative process with UxuR [2, 3, 4]. In 1986, Blanco et al. proposed that total repression of UidR is achieved in the presence of UxuR, suggesting the possibility that UidR and UxuR form a complex. Independently, each repressor binds to DNA separately [2, 3, 7].

Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) References
UidR Functional   nd nd nd
Evolutionary Family: TetR/AcrR
TFBs length: 16
TFBs symmetry: inverted-repeat
Sensing class: External sensing using transported metabolites
Connectivity class: Local Regulator
Gene name: uidR
  Genome position: 1696462-1697052
  Length: 591 bp / 196 aa
Operon name: uidR
TU(s) encoding the TF:
Transcription unit        Promoter

Regulated gene(s) uidA, uidB, uidC, uidR
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
carbon compounds (3)
Porters (Uni-, Sym- and Antiporters) (1)
membrane (1)
Transcription related (1)
repressor (1)
Regulated operon(s) uidABC, uidR
First gene in the operon(s) uidA, uidR
Simple and complex regulons CRP,UidR,UxuR
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)

Transcription factor regulation    

Transcription factor binding sites (TFBSs) arrangements

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) References
  UidR repressor uidAp nd -153.5 -234.5 uidA, uidB, uidC
1696298 1696313 [EXP-IEP-GENE-EXPRESSION-ANALYSIS] W [1], [1], [2], [3]
  UidR repressor uidRp Sigma70 nd nd uidR nd nd [EXP-IEP-GENE-EXPRESSION-ANALYSIS] W [1]

Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation