Hns-dependent flhDCregulator, HdfR, negatively regulates the expression of the flagellar master operon, flhDC |CITS:| and positively regulates the expression of the gltBD operon |CITS:|. H-NS is a direct activator of the flhDC operon and represses transcription of hdfR.
HdfR is a transcriptional regulator that belongs to the LysR family. It consist of two domains, an amino-terminal domain that contains a potential helix-turn-helix DNA-binding motif and a carboxy-terminal domain involved in co-inducer recognition |CITS:|. Little is known about the regulatory role of HdfR, and the binding sites for this transcription factor have not yet been determined.
In systematic studies of oligomerization, it was shown that some members of the LysR family, like HdfR, interact with other members of the family to form heterodimers, but the physiological significance of this is unknown |CITS:[ 21187915]|.
|Connectivity class:||Local Regulator|
|Length:||840 bp / 279 aa|
|TU(s) encoding the TF:||
|Regulated gene(s)||flhC, flhD, gltB, gltD, gltF|
|Multifun term(s) of regulated gene(s)||
MultiFun Term (List of genes associated to the multifun term)
flhC, flhD, gltF
Transcription related (2)
motility, chemotaxis, energytaxis (aerotaxis, redoxtaxis etc) (2)
nitrogen metabolism (2)
|Regulated operon(s)||flhDC, gltBDF|
|First gene in the operon(s)||flhD, gltB|
|Simple and complex regulons|
|Simple and complex regulatory phrases||Regulatory phrase (List of promoters regulated by the phrase)|
|Functional conformation||Function||Promoter||Sigma factor||Central Rel-Pos||Distance to first Gene||Genes||Sequence||LeftPos||RightPos||Evidence (Confirmed, Strong, Weak)||References|
|HdfR||repressor||flhDp||Sigma70||nd||nd||flhD, flhC||nd||nd||[BPP], [GEA]|||
|HdfR||activator||gltBp||Sigma70||nd||nd||gltB, gltD, gltF||nd||nd||[BPP]|||
|Evolutionary conservation of regulatory elements|