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Synonyms: SlyA |
Summary:
SlyA (for "hemolytic protein in Salmonella") was initially identified in Salmonella, although little is known about the regulator role of SlyA. It has been demonstrated that SlyA increases expression of hemolysin E by antagonizing the negative effects of H-NS [1, 3] SlyA belongs to the MarR family of transcriptional regulators. This protein consist of two domains, an amino-terminal domain involved in dimerization and a carboxy-terminal domain indispensable for DNA recognition [] It is known that SlyA recognizes a short palindromic DNA sequence of 12 bp [3] |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Evolutionary Family: | MarR | ||||||||||||
Connectivity class: | Local Regulator | ||||||||||||
Gene name: | slyA | ||||||||||||
Genome position: | 1720390-1720824 | ||||||||||||
Length: | 435 bp / 144 aa | ||||||||||||
Operon name: | slyA | ||||||||||||
TU(s) encoding the TF: |
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Regulon |
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Regulated gene(s) | cas1, cas2, casA, casB, casC, casD, casE, fecI, fecR, gspC, gspD, gspE, gspF, gspG, gspH, gspI, gspJ, gspK, gspL, gspM, gspO, hlyE, leuO, paaA, paaB, paaC, paaD, paaE, paaF, paaG, paaH, paaI, paaJ, paaK, pagP, rmf, rsd | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
Putative uncharacterized transport protein (11)
carbon compounds (10)
defense/survival (7)
Transcription related (4)
sigma factors, anti-sigmafactors (2)
Read more >
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Regulated operon(s) | casABCDE12, fecIR, gspCDEFGHIJKLMO, hlyE, leuO, paaABCDEFGHIJK, pagP, rmf, rsd | ||||||
First gene in the operon(s) | casA, fecI, gspC, hlyE, leuO, paaA, pagP, rmf, rsd | ||||||
Simple and complex regulons | ArcA,CRP,McbR,RcdA,SdiA,SlyA,ppGpp ArcA,McbR,RcdA,SdiA,SlyA CRP,FNR,Fis,H-NS,SlyA CRP,H-NS,LeuO,SlyA CRP,IHF,PaaX,SlyA Read more > | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Transcription factor regulation |
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Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
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SlyA | activator | casAp | Sigma70 | 81.5 | -100.5 | casA, casB, casC, casD, casE, cas1, cas2 |
gtgaatgtgaTTATTGAATTAAttacgccgta
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2884233 | 2884244 | [AIBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [4] | |
SlyA | repressor | fecIp | Sigma70 | -62.5 | -109.5 | fecI, fecR |
cttataacacTTAGAAAAACAAcatgttaaaa
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4518339 | 4518350 | [AIBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [4] | |
SlyA | activator | gspCp2 | Sigma70 | -49.5 | -100.5 | gspC, gspD, gspE, gspF, gspG, gspH, gspI, gspJ, gspK, gspL, gspM, gspO |
taaatacataTTACTAATATAAataaattttg
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3455472 | 3455483 | [AIBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [4] | |
SlyA | activator | hlyEp | nd | -55.5 | -127.5 | hlyE |
tgtttgatatTTATCATATTAAtagaaataaa
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1230516 | 1230527 | [BPP], [GEA] | [1], [3], [5] | |
SlyA | activator | hlyEp | nd | -44.5 | -116.5 | hlyE |
tatcatattaATAGAAATAAAGacattgacgc
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1230505 | 1230516 | [BPP], [GEA] | [1], [3], [5], [6], [7] | |
SlyA | activator | hlyEp | nd | 52.5 | -20.5 | hlyE |
tcattacaatTTATATATTTAAagaggcgaat
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1230409 | 1230420 | [BPP], [GEA] | [5] | |
SlyA | activator | hlyEp | nd | 61.5 | -11.5 | hlyE |
tttatatattTAAAGAGGCGAAtgattatgac
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1230400 | 1230411 | [BPP], [GEA] | [5] | |
SlyA | activator | hlyEp | nd | 76.5 | 4.5 | hlyE |
aggcgaatgaTTATGACTGAAAtcgttgcaga
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1230385 | 1230396 | [BPP], [GEA] | [5] | |
SlyA | activator | hlyEp | nd | 90.5 | 18.5 | hlyE |
gactgaaatcGTTGCAGATAAAacggtagaag
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1230371 | 1230382 | [BPP], [GEA] | [5] | |
SlyA | activator | leuOp | Sigma70 | -125.5 | -305.5 | leuO |
atgttaagaaTTAATGCATTAAatatataaat
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84057 | 84068 | [AIBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [4] | |
SlyA | activator | leuOp | Sigma70 | -117.5 | -297.5 | leuO |
aattaatgcaTTAAATATATAAattaattatt
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84065 | 84076 | [AIBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [4] | |
SlyA | activator | paaAp | Sigma70 | -177.5 | -239.5 | paaA, paaB, paaC, paaD, paaE, paaF, paaG, paaH, paaI, paaJ, paaK |
ttgctaatagTTAAATCGCGAAtcataaaaag
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1453682 | 1453693 | [AIBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [4] | |
SlyA | activator | paaAp | Sigma70 | -74.5 | -136.5 | paaA, paaB, paaC, paaD, paaE, paaF, paaG, paaH, paaI, paaJ, paaK |
aaataatgatTTATAAAAATAGggtgcgaaat
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1453785 | 1453796 | [AIBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [4] | |
SlyA | activator | paaAp | Sigma70 | -19.5 | -81.5 | paaA, paaB, paaC, paaD, paaE, paaF, paaG, paaH, paaI, paaJ, paaK |
atttgtgattTTACTTAACTATtgtgtaactt
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1453840 | 1453851 | [AIBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [4] | |
SlyA | activator | pagPp | nd | -109.5 | -140.5 | pagP |
atctttaatcGATGCGCGGAAAtatttaactt
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656411 | 656422 | [GEA], | [8] | |
SlyA | activator | pagPp | nd | -89.0 | -120.0 | pagP |
aatatttaacTTGAACAAGCGGAAataaatagag
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656431 | 656444 | [GEA], | [8] | |
SlyA | activator | pagPp | nd | -10.0 | -41.0 | pagP |
taattgtagcTTTGCTATGCTAGTagtagatttt
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656510 | 656523 | [GEA], | [8] | |
SlyA | activator | rmfp | nd | nd | nd | rmf | nd | nd | [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/GS)], [CV(GEA/GS)], [GEA], [GS] | [9] | ||
SlyA | activator | rsdp2 | Sigma70 | nd | nd | rsd | nd | nd | [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/GS)], [CV(GEA/GS)], [GEA], [GS] | [9] |
Functional conformation | Function | Object name | Object type | Distance to first Gene | Sequence | LeftPos | RightPos | Center Position | Growth Condition | Evidence (Confirmed, Strong, Weak) | References | |
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SlyA | activator | slyA | tu | nd |
atatattgcgTTAGATTAATAAatattcttta
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1720980 | 1720991 | 1720985.5 | nd | [AIBSCS], [BPP], [GEA] | [4] | |
SlyA | activator | nd | tu | nd |
tacgaagagaTCAGGATGATAAcgatgaaaaa
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997854 | 997865 | 997859.5 | nd | [AIBSCS], [BPP], [GEA] | [4] | |
SlyA | activator | nd | tu | nd |
ttaattacacTTAAGGTGTATAttttctatgc
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4568763 | 4568774 | 4568768.5 | nd | [AIBSCS], [BPP], [GEA] | [4] | |
SlyA | activator | slyA | tu | nd |
gcataatatcTTAGCAAGCTAAttataaggag
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1720841 | 1720852 | 1720846.5 | nd | [AIBSCS], [BPP], [GEA] | [4] | |
SlyA | repressor | nd | tu | nd |
ttttcttacaTTATGCTGGGAAccaacgacct
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4531988 | 4531999 | 4531993.5 | nd | [AIBSCS], [BPP], [GEA] | [4] | |
SlyA | repressor | nd | tu | nd |
atcctcattaTTTCAACCATAAtcactggtct
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4531834 | 4531845 | 4531839.5 | nd | [AIBSCS], [BPP], [GEA] | [4] |
Alignment and PSSM for SlyA TFBSs | ![]() |
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Aligned TFBS of SlyA |
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Sequence | |
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ATTACTAATATAAAT | |
ATTAAATATATAAAT | |
ATGATTTATAAAAAT | |
ATTAATGCATTAAAT | |
TTTAAATATATAAAT | |
ATTATTGAATTAATT | |
ATTAATATGATAAAT | |
TTTATTTCTATTAAT | |
TTCGCCTCTTTAAAT | |
ATTCGCGATTTAACT | |
ATAGTTAAGTAAAAT | |
AACACTTAGAAAAAC | |
ATGACTGAAATCGTT | |
GTTGCAGATAAAACG |
Position weight matrix (PWM). SlyA matrix-quality result |
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A 10 1 1 10 4 3 3 10 3 9 4 12 13 10 0 C 0 0 2 1 5 2 0 3 0 0 0 1 0 2 1 G 1 0 2 3 1 0 5 0 3 0 0 0 1 0 1 T 3 13 9 0 4 9 6 1 8 5 10 1 0 2 12 |
Consensus |
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; consensus.strict aTtactgatatAAaT ; consensus.strict.rc ATTTATATCAGTAAT ; consensus.IUPAC aTtrctkmkwtAAaT ; consensus.IUPAC.rc ATTTAWMKMAGYAAT ; consensus.regexp aTt[ag]ct[gt][ac][gt][at]tAAaT ; consensus.regexp.rc ATTTA[AT][AC][GT][AC]AG[CT]AAT |
Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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