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AlpA DNA-binding transcriptional dual regulator

Synonyms: AlpA
AlpA is a transcriptional regulator of intA expression [1]. It is part of the CP4-57 cryptic prophage that is similar to bacteriophage P4 [2]. alpA was first identified as a multicopy suppressor of lon mutants that leads to the expression of an alternative Lon protease activity named Alp [1, 3]. AlpA expression leads to increased synthesis of IntA, which results in excision of the CP4-57 cryptic prophage. The excision inactivates the gene upstream of intA, ssrA, encoding |FRAME: SSRA-RNA| [2]. Expression of alpA increases 6.5-fold upon deletion of tqsA; alpA expression may thus be involved in biofilm formation [4]. CP4-57: "cryptic P4-like prophage at min 57" [2] AlpA: "alternative Lon protease" [3] Read more >

Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
AlpA Functional   [IMP] [1]
Evolutionary Family: AlpA
Connectivity class: