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AlpA DNA-binding transcriptional dual regulator

Synonyms: AlpA
AlpA is a transcriptional regulator of intA expression [1]. It is part of the CP4-57 cryptic prophage that is similar to bacteriophage P4 [2]. alpA was first identified as a multicopy suppressor of lon mutants that leads to the expression of an alternative Lon protease activity named Alp [1, 3]. AlpA expression leads to increased synthesis of IntA, which results in excision of the CP4-57 cryptic prophage. The excision inactivates the gene upstream of intA, ssrA, encoding |FRAME: SSRA-RNA| [2]. Expression of alpA increases 6.5-fold upon deletion of tqsA; alpA expression may thus be involved in biofilm formation [4]. CP4-57: "cryptic P4-like prophage at min 57" [2] AlpA: "alternative Lon protease" [3] Read more >

Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
AlpA Functional   [IMP] [1]
Evolutionary Family: AlpA
Connectivity class: Local Regulator
Gene name: alpA
  Genome position: 2758644-2758856
  Length: 213 bp / 70 aa
Operon name: alpA
TU(s) encoding the TF:
Transcription unit        Promoter

Regulated gene(s)
Regulated operon(s)
First gene in the operon(s)
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)

Transcription factor regulation    

Transcription factor binding sites (TFBSs) arrangements

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References

High-throughput Transcription factor binding sites (TFBSs)

  Functional conformation Function Object name Object type Distance to first Gene Sequence LeftPos RightPos Center Position Growth Condition Evidence (Confirmed, Strong, Weak) References
  AlpA activator intA Transcription-Unit nd
nd nd nd nd [BPP], [GEA], [IGI] [1]

Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation