|Synonyms: DsdC, DsdC-D-serine|
In the presence of d-serine, the D-serine deaminase protein, DsdC, activates the transcription of genes involved in d-serine detoxification, and in the absence of the metabolite it is autorepressed |CITS: |.
DsbC belongs to the LysR family of bacterial transcriptional regulators and contains a possible helix-turn-helix motif for DNA binding in the C-terminal domain. This protein shows 50% similarity to the GcvA protein |CITS: |.
The dsbC gene is located next to an operon ( dsdXA ) regulated by DsbC, but facing in the opposite direction. The activation effect of DsdC on this operon is enhanced by CRP, but CRP cannot act alone on the operon |CITS:|.
A DNA-binding site recognized by the dimer of DsbC has not been identified.
|Sensing class:||Sensing external and internal signals|
|Connectivity class:||Local Regulator|
|Length:||936 bp / 311 aa|
|TU(s) encoding the TF:||
|Regulated gene(s)||dsdA, dsdC, dsdX|
|Multifun term(s) of regulated gene(s)||
MultiFun Term (List of genes associated to the multifun term)
amino acids (2)
Transcription related (1)
dsdCRead more >
|Regulated operon(s)||dsdC, dsdXA|
|First gene in the operon(s)||dsdA, dsdC, dsdX|
|Simple and complex regulons|
|Simple and complex regulatory phrases||Regulatory phrase (List of promoters regulated by the phrase)|
|Functional conformation||Function||Promoter||Sigma factor||Central Rel-Pos||Distance to first Gene||Genes||Sequence||LeftPos||RightPos||Evidence (Confirmed, Strong, Weak)||References|
|DsdC-D-serine||activator||dsdXp||Sigma70||nd||nd||dsdX, dsdA||nd||nd||[GEA]||, |
|Evolutionary conservation of regulatory elements|