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EbgR DNA-binding transcriptional repressor

Synonyms: EbgR
EbgR (for "evolved β-galactosidase repressor") negatively regulates genes involved in the evolved β-galactosidase system, which constitutes an alternative for lactose utilization in cells with mutations on the lacZ gene [2, 3]. The wild-type Ebg enzyme, encoded by the ebg operon, is not efficient enough to permit growth on lactose. Mutations in ebgR and ebgA, however, enhance its catalytic activity and enable rapid growth on lactose as a sole carbon source [2, 3]. EbgR belongs to the GalR-LacI family of transcriptional regulators. There is strong evidence that the ebg and lac operons share a common origin in evolution [2]. EbgR diverged from other repressors shortly after the divergence of the Gram positive from the Gram negative eubacteria, approximately 2.2 billion years ago [4] Reviews: [3, 4] Read more >

Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) References
EbgR Functional   nd nd nd
Evolutionary Family: GalR/LacI
TFBs symmetry: inverted-repeat
Connectivity class: Local Regulator
Gene name: ebgR
  Genome position: 3221466-3222449
  Length: 984 bp / 327 aa
Operon name: ebgR
TU(s) encoding the TF:
Transcription unit        Promoter

Regulated gene(s) ebgA, ebgC
Multifun term(s) of regulated gene(s)
carbon compounds (2)
Regulated operon(s) ebgAC
First gene in the operon(s) ebgA
Simple and complex regulons CRP,EbgR
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)

Transcription factor regulation    

Transcription factor binding sites (TFBSs) arrangements

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) References
  EbgR repressor ebgAp Sigma70 nd nd ebgA, ebgC nd nd [EXP-IEP-GENE-EXPRESSION-ANALYSIS] W [1]

Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation