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Synonyms: FucR-L-fuculose-1-P, FucR |
Summary:
"Fucose regulator," FucR, acts as an activator of operons involved in fucose transport and degradation [5]. During induction by fuculose 1-phosphate, FucR binds to DNA, positively autoregulating itself and simultaneously activating transcription of the divergent fucAO operon. Expression of this operon requires growth on L-fucose or L-rhamnose under anaerobic conditions [1, 4]. The repressor gene of this operon is positioned at the 3' end of the operon itself [6]. As a member of the DeoR family, FucR features an N-terminal domain containing a putative helix-turn-helix motif [2]. |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Evolutionary Family: | DeoR | ||||||||||||||||||
Sensing class: | External sensing using transported metabolites | ||||||||||||||||||
Connectivity class: | Local Regulator | ||||||||||||||||||
Gene name: | fucR | ||||||||||||||||||
Genome position: | 2939368-2940099 | ||||||||||||||||||
Length: | 732 bp / 243 aa | ||||||||||||||||||
Operon name: | fucPIKUR | ||||||||||||||||||
TU(s) encoding the TF: |
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Regulon |
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Regulated gene(s) | fucA, fucI, fucK, fucO, fucP, fucR, fucU | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
carbon compounds (7)
glycolate metabolism (1)
Porters (Uni-, Sym- and Antiporters) (1)
membrane (1)
Transcription related (1)
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Regulated operon(s) | fucAO, fucPIKUR | ||||||
First gene in the operon(s) | fucA, fucP | ||||||
Simple and complex regulons | CRP,FucR | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Transcription factor regulation |
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Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
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FucR-L-fuculose-1-P | activator | fucAp | Sigma70 | nd | nd | fucA, fucO | nd | nd | [CV(GEA)], [GEA], [IMP] | [3], [4] | ||
FucR-L-fuculose-1-P | activator | fucPp | Sigma70 | nd | nd | fucP, fucI, fucK, fucU, fucR | nd | nd | [GEA] | [3], [4] |
Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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