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GatR DNA-binding transcriptional repressor

Synonyms: GatR
Summary:
Galactitol regulator, GatR, negatively controls the expression of an operon involved in transport and catabolism of hexitol galactitol [1, 2] The gatYZABCD operon is expressed constitutively due to an insertion of IS3E into the gatR gene [2] Currently, no DNA-binding sites for this regulator have been reported in the literature.
As a member of the DeoR family, GatR features an N-terminal domain containing a putative helix-turn-helix motif [2, 3]


Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
GatR     nd nd
Sensing class: External sensing using transported metabolites
Connectivity class: Local Regulator
Gene name: gatR_1
  Genome position: 2169693-2170139
  Length: 447 bp / 148 aa
Operon name: gatR_1
TU(s) encoding the TF:
Transcription unit        Promoter
gatR_1
null
Gene name: gatR_2
  Genome position: 2171395-2171733
  Length: 339 bp / 112 aa
Operon name: gatR_2
TU(s) encoding the TF:
Transcription unit        Promoter
gatR_2
gatR_2p


Regulon       
Regulated gene(s) gatA, gatB, gatC, gatD, gatY, gatZ
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
carbon compounds (6)
Phosphotransferase Systems (PEP-dependent PTS) (3)
membrane (2)
Regulated operon(s) gatYZABCD
First gene in the operon(s) gatY
Simple and complex regulons ArcA,CRP,GatR
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)


Transcription factor binding sites (TFBSs) arrangements       

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  GatR repressor gatYp Sigma70 nd nd gatY, gatZ, gatA, gatB, gatC, gatD nd nd [GEA] [1], [2]


Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation


Evidence    

 [GEA] Gene expression analysis



Reference(s)    

 [1] Nobelmann B., Lengeler JW., 1995, Sequence of the gat operon for galactitol utilization from a wild-type strain EC3132 of Escherichia coli., Biochim Biophys Acta. 1262(1):69-72

 [2] Nobelmann B., Lengeler JW., 1996, Molecular analysis of the gat genes from Escherichia coli and of their roles in galactitol transport and metabolism., J Bacteriol. 178(23):6790-5

 [3] Zeng G., Ye S., Larson TJ., 1996, Repressor for the sn-glycerol 3-phosphate regulon of Escherichia coli K-12: primary structure and identification of the DNA-binding domain., J Bacteriol. 178(24):7080-9



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