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Synonyms: GutM |
Summary:
The "glucitol regulator," GutM, is a DNA-binding transcription factor that regulates an operon (gut) involved in transport and utilization of glucitol [1, 2]. This regulator is located in the unusual gut operon, which contains two glucitol-specific transcription factors, GutR and GutM, that regulate this operon negatively and positively, respectively; both regulators control transcription of glucitol PTS permease [1] Expression of gutM is increased in the presence of glucitol and in the absence of glucose. Although GutM binding does not depend on the presence of glucitol, this compound appears to be necessary for derepressing gutM, perhaps by interacting with GutR [1] To activate transcription, GutM recognizes DNA-binding sites, but no consensus sequence has been identified. When this protein activates genes involved in glucitol transport and utilization, it appears to bind to their regulatory regions without a coeffector [1] In addition, Yamada et al. Read more > |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Evolutionary Family: | GutM | ||||||||||||
Sensing class: | External sensing using transported metabolites | ||||||||||||
Connectivity class: | Local Regulator | ||||||||||||
Gene name: | gutM | ||||||||||||
Genome position: | 2828621-2828980 | ||||||||||||
Length: | 360 bp / 119 aa | ||||||||||||
Operon name: | srlAEBD-gutM-srlR-gutQ | ||||||||||||
TU(s) encoding the TF: |
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Regulon |
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Regulated gene(s) | gutM, gutQ, srlA, srlB, srlD, srlE, srlR | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
carbon compounds (6)
Phosphotransferase Systems (PEP-dependent PTS) (3)
Transcription related (2)
activator (1)
core region (1)
Read more >
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Regulated operon(s) | srlAEBD-gutM-srlR-gutQ | ||||||
First gene in the operon(s) | srlA | ||||||
Simple and complex regulons | CRP,GutM,H-NS,SrlR | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Transcription factor regulation |
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Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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