RegulonDB RegulonDB 10.10:Regulon Page

GutM DNA-binding transcriptional activator

Synonyms: GutM
The "glucitol regulator," GutM, is a DNA-binding transcription factor that regulates an operon (gut) involved in transport and utilization of glucitol [1, 2]. This regulator is located in the unusual gut operon, which contains two glucitol-specific transcription factors, GutR and GutM, that regulate this operon negatively and positively, respectively; both regulators control transcription of glucitol PTS permease [1] Expression of gutM is increased in the presence of glucitol and in the absence of glucose. Although GutM binding does not depend on the presence of glucitol, this compound appears to be necessary for derepressing gutM, perhaps by interacting with GutR [1] To activate transcription, GutM recognizes DNA-binding sites, but no consensus sequence has been identified. When this protein activates genes involved in glucitol transport and utilization, it appears to bind to their regulatory regions without a coeffector [1] In addition, Yamada et al.
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Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
GutM Functional   nd nd
Evolutionary Family: GutM
Sensing class: External sensing using transported metabolites
Connectivity class: Local Regulator
Gene name: gutM
  Genome position: 2828621-2828980
  Length: 360 bp / 119 aa
Operon name: srlAEBD-gutM-srlR-gutQ
TU(s) encoding the TF:
Transcription unit        Promoter

Regulated gene(s) gutM, gutQ, srlA, srlB, srlD, srlE, srlR
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
carbon compounds (6)
Phosphotransferase Systems (PEP-dependent PTS) (3)
Transcription related (2)
activator (1)
core region (1)
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Regulated operon(s) srlAEBD-gutM-srlR-gutQ
First gene in the operon(s) srlA
Simple and complex regulons CRP,GutM,H-NS,SrlR
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)

Transcription factor regulation    

Transcription factor binding sites (TFBSs) arrangements

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  GutM activator srlAp Sigma70 nd nd srlA, srlE, srlB, srlD, gutM, srlR, gutQ nd nd [GEA], [BPP] [1]

Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation